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AMR Drug RepurposingSmart Screeningresearch prototype

Research dashboard

Search approved medicines for AI-predicted activity against four drug-resistant pathogens, and see what evidence is already documented for each one.

TryTuberculosisMRSAKlebsiella infectionE. coli infection

1,761

Approved medicines

Approved medicines matched to the FDA Orange Book, antimicrobials included

1,276

Medicines with ≥40% AI-predicted activity

Against at least one of the four supported pathogens; each medicine counted once

1,019

Repurposing candidates

Of those, the medicines that are not already antimicrobials

How the repurposing candidates are counted

  1. 1,761approved medicines

  2. 1,276with AI-predicted activity ≥40% against at least one pathogen

    − 485 below ≥40%, not counted

  3. 1,120not already antimicrobials

    − 156 already antimicrobials, set aside

  4. 1,019repurposing candidates

    − 101 needing review, kept in the library

Existing antimicrobials are identified from WHO ATC codes and FDA pharmacologic classes. Medicines needing review (neither source says whether they are antimicrobials) stay in the approved-medicine download, marked “unclassified”. They are not assumed to be non-antimicrobials, so they are not counted as candidates.

Downloads

Download approved medicines (CSV)1,761 rowsDownload repurposing candidates (CSV)1,019 rows

Pathogen coverage

A medicine can count under more than one

Registered studies

A registration describes a study; it does not establish a positive result.

Condition
When these studies started38,873 of 39,548 have a start date · most in 2021 (1,903)
193119812030

  • This is a Clinical Study to Assess Whether the Combination of SJ733 and Tafenoquine Will be a Safe and Rapidly Acting Anti-malarial for the Radical Cure of P. Vivax Malaria

    NCT07430592 · start 2026-10-01

    Registered record
    Registry ID
    NCT07430592
    Conditions
    Malaria; Malaria Vivax; Radical Cure
    Interventions
    SJ733/TQ placebo; CQ/TQ Placebo; CQ/TQ; SJ733 (3-day)/TQ; SJ733 (2-day ) /TQ; SJ733(1-day)/TQ
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2028-11-20
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Malaria Vivax; Radical Cure
    InterventionSJ733/TQ placebo; CQ/TQ Placebo; CQ/TQ; SJ733 (3-day)/TQ +2 more
    PhasePhase 2
    Registry statusNot yet recruiting

  • Comparison of Topical Calcipotriol and Intralesional Steroids in Alopecia Areata

    NCT07453238 · start 2026-10-01

    Registered record
    Registry ID
    NCT07453238
    Conditions
    Alopecia Areata
    Interventions
    Calcipotriol; Triamcinolone Acetonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2027-03-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlopecia Areata
    InterventionCalcipotriol; Triamcinolone Acetonide
    PhasePhase 4
    Registry statusNot yet recruiting

  • Integrative Liver-Targeted Therapy for Diabetic Macular Edema: Using "Tauroursodeoxycholate" or Traditional Chinese Medicine.

    NCT07457632 · start 2026-10-01

    Registered record
    Registry ID
    NCT07457632
    Conditions
    Diabetic Macular Edema (DME)
    Interventions
    Tauroursodeoxycholate (TUDCA); Traditional Chinese Medicine (mQJDHW); placebo capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2028-12-31
    Enrolment
    69

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Macular Edema (DME)
    InterventionTauroursodeoxycholate (TUDCA); Traditional Chinese Medicine (mQJDHW); placebo capsule
    PhasePhase 2
    Registry statusNot yet recruiting

  • A Study to Learn About the Study Medicine NURTEC® ODT 75 mg After it is Released Into the Markets in Korea

    NCT07497854 · start 2026-10-01

    Registered record
    Registry ID
    NCT07497854
    Conditions
    Migraine With or Without Aura
    Interventions
    Rimegepant sulfate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2030-08-01
    Enrolment
    3,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine With or Without Aura
    InterventionRimegepant sulfate
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Pain Control During ESWL Using Non-Opioid Analgesics

    NCT07512297 · start 2026-10-01

    Registered record
    Registry ID
    NCT07512297
    Conditions
    Urolithiasis; Kidney Stones; Ureteral Stones
    Interventions
    Ibuprofen (Brufen®); Paracetamol (drug); Tenoxicam; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2027-03-01
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrolithiasis; Kidney Stones; Ureteral Stones
    InterventionIbuprofen (Brufen®); Paracetamol (drug); Tenoxicam; Placebo
    PhasePhase 4
    Registry statusNot yet recruiting

  • Therapeutics for Moderate and Severe Dengue

    NCT07543458 · start 2026-10-01

    Registered record
    Registry ID
    NCT07543458
    Conditions
    Dengue; Severe Dengue; Mosquito-Borne Diseases; Vector Borne Diseases; Arbovirus Infections; Flavivirus Infections; RNA Virus Infections; Hemorrhagic Fever
    Interventions
    Placebo; Dexamethasone; N-Acetylcysteine; Standard of care; Baricitinib
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2031-07-31
    Enrolment
    8,800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDengue; Severe Dengue; Mosquito-Borne Diseases; Vector Borne Diseases +4 more
    InterventionPlacebo; Dexamethasone; N-Acetylcysteine; Standard of care +1 more
    PhasePhase 3
    Registry statusNot yet recruiting

  • The OK Daily Study

    NCT07620236 · start 2026-10-01

    Registered record
    Registry ID
    NCT07620236
    Conditions
    Infant Vitamin K Status; Vitamin K Deficiency Bleeding
    Interventions
    Combined MK-7 + vitamin D3 drops; Vitamin D3 Drops; MK-7 capsules
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2028-08-01
    Enrolment
    134

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfant Vitamin K Status; Vitamin K Deficiency Bleeding
    InterventionCombined MK-7 + vitamin D3 drops; Vitamin D3 Drops; MK-7 capsules
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Effect of Abdominal Ice Pack After vNOTES Hysterectomy

    NCT07626684 · start 2026-10-01

    Registered record
    Registry ID
    NCT07626684
    Conditions
    Hysterectomy, Benign Uterine Diseases; Hysterectomy, Vaginal; vNOTES; Postoperative Pain Following Hysterectomy; Patient Comfort and Safety; Bowel Functions; Analgesic Consumption
    Interventions
    Abdominal Ice Pack + ERAS
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Enrolling by invitation
    Start
    2026-10-01
    Completion
    2027-03-15
    Enrolment
    122

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHysterectomy, Benign Uterine Diseases; Hysterectomy, Vaginal; vNOTES; Postoperative Pain Following Hysterectomy +3 more
    InterventionAbdominal Ice Pack + ERAS
    PhaseNot applicable
    Registry statusEnrolling by invitation

  • Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical Assessment for Flap Perfusion in Head and Neck Reconstruction (VISION Trial)

    NCT07635420 · start 2026-10-01

    Registered record
    Registry ID
    NCT07635420
    Conditions
    Head and Neck Cancer (H&N); Free Tissue Flaps; Free Flap; Free Flap Evaluation; Indocyanine Green; Indocyanine Green (ICG); Microsurgery; Randomised Controlled Trial
    Interventions
    Indocyanine Green; Standard clinical perfusion assessment
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-10-01
    Completion
    2029-08-01
    Enrolment
    244

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHead and Neck Cancer (H&N); Free Tissue Flaps; Free Flap; Free Flap Evaluation +4 more
    InterventionIndocyanine Green; Standard clinical perfusion assessment
    PhasePhase 4
    Registry statusRecruiting

  • LOw DosE Spironolactone, chlorThAlidone oR Combination in CKD Trial

    NCT07645300 · start 2026-10-01

    Registered record
    Registry ID
    NCT07645300
    Conditions
    Hypertension Treated With Antihypertensive Drugs; Chronic Kidney Disease, 3B and 4
    Interventions
    phase 2A Chlorthalidone; phase 2A Spironolactone; phase 2A Chlorthalidone + Spironolactone; phase 2B Chlorthalidone LD + Spironolactone LD
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2032-06-30
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension Treated With Antihypertensive Drugs; Chronic Kidney Disease, 3B and 4
    Interventionphase 2A Chlorthalidone; phase 2A Spironolactone; phase 2A Chlorthalidone + Spironolactone; phase 2B Chlorthalidone LD + Spironolactone LD
    PhasePhase 2
    Registry statusNot yet recruiting

  • Deep Cervical Lymphovenous Anastomosis for Severe Alzheimer's Disease

    NCT07669272 · start 2026-10-01

    Registered record
    Registry ID
    NCT07669272
    Conditions
    Alzheimer s Disease
    Interventions
    Deep Cervical Lymphovenous Anastomosis; Routine Treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2029-09-30
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer s Disease
    InterventionDeep Cervical Lymphovenous Anastomosis; Routine Treatment
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Nutrition Intervention Combined With Resmetirom for MASH

    NCT07680478 · start 2026-10-01

    Registered record
    Registry ID
    NCT07680478
    Conditions
    Metabolic Dysfunction-Associated Steatohepatitis (MASH)
    Interventions
    Resmetirom therapy; Comprehensive nutritional intervention; Standard dietary support
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2028-06-30
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolic Dysfunction-Associated Steatohepatitis (MASH)
    InterventionResmetirom therapy; Comprehensive nutritional intervention; Standard dietary support
    PhasePhase 4
    Registry statusNot yet recruiting

  • Enhancing Rehabilitation in Aging Study (ERAS)

    NCT07704385 · start 2026-10-01

    Registered record
    Registry ID
    NCT07704385
    Conditions
    Adults
    Interventions
    Istradefylline 20 mg; Placebo; Acute Intermittent Hypoxia (AIH)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2031-12-31
    Enrolment
    38

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdults
    InterventionIstradefylline 20 mg; Placebo; Acute Intermittent Hypoxia (AIH)
    PhasePhase 1 / Phase 2
    Registry statusNot yet recruiting

  • Venetoclax Plus Zanubrutinib for the Treatment of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

    NCT07734038 · start 2026-10-01

    Registered record
    Registry ID
    NCT07734038
    Conditions
    Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma
    Interventions
    Biospecimen Collection; Bone Marrow Aspiration; Bone Marrow Biopsy; Computed Tomography; Magnetic Resonance Imaging; Venetoclax; Zanubrutinib
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2026-10-01
    Completion
    2027-12-31
    Enrolment
    155

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma
    InterventionBiospecimen Collection; Bone Marrow Aspiration; Bone Marrow Biopsy; Computed Tomography +3 more
    PhasePhase 2
    Registry statusRecruiting

  • Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver Transplantation

    NCT07759453 · start 2026-10-01

    Registered record
    Registry ID
    NCT07759453
    Conditions
    Liver Transplant; Carbapenem-resistant Enterobacterales; CRE Colonization
    Interventions
    Ceftazidime - Avibactam ( CAZ-AVI); Meropenem-Vaborbactam; Imipenem+Relebactam; Cefiderocol; Aztreonam; Eravacycline; Aztreonam-Avibactam; Amoxi Clavulanate; Piperacillin + Tazobactam; Tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2029-09-30
    Enrolment
    168

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Transplant; Carbapenem-resistant Enterobacterales; CRE Colonization
    InterventionCeftazidime - Avibactam ( CAZ-AVI); Meropenem-Vaborbactam; Imipenem+Relebactam; Cefiderocol +6 more
    PhasePhase 3
    Registry statusNot yet recruiting

AI-predicted activity is a model’s estimate that a molecule is active against a pathogen in the laboratory. It is not clinical effectiveness. The models describe each pathogen species; the data behind them rarely records resistant strains.