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AMR Drug RepurposingSmart Screeningresearch prototype

Research dashboard

Search approved medicines for AI-predicted activity against four drug-resistant pathogens, and see what evidence is already documented for each one.

TryTuberculosisMRSAKlebsiella infectionE. coli infection

1,761

Approved medicines

Approved medicines matched to the FDA Orange Book, antimicrobials included

1,276

Medicines with ≥40% AI-predicted activity

Against at least one of the four supported pathogens; each medicine counted once

1,019

Repurposing candidates

Of those, the medicines that are not already antimicrobials

How the repurposing candidates are counted

  1. 1,761approved medicines

  2. 1,276with AI-predicted activity ≥40% against at least one pathogen

    − 485 below ≥40%, not counted

  3. 1,120not already antimicrobials

    − 156 already antimicrobials, set aside

  4. 1,019repurposing candidates

    − 101 needing review, kept in the library

Existing antimicrobials are identified from WHO ATC codes and FDA pharmacologic classes. Medicines needing review (neither source says whether they are antimicrobials) stay in the approved-medicine download, marked “unclassified”. They are not assumed to be non-antimicrobials, so they are not counted as candidates.

Downloads

Download approved medicines (CSV)1,761 rowsDownload repurposing candidates (CSV)1,019 rows

Pathogen coverage

A medicine can count under more than one

Registered studies

A registration describes a study; it does not establish a positive result.

Condition
When these studies started38,873 of 39,548 have a start date · most in 2021 (1,903)
193119812030

  • Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches

    NCT07444827 · start 2027-01-01

    Registered record
    Registry ID
    NCT07444827
    Conditions
    Anesthesia, Local
    Interventions
    Traditional adductor canal block; NVM (nerve to vastus medialis) targeted adductor canal block; Chloroprocaine Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2027-01-01
    Completion
    2027-12-01
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia, Local
    InterventionTraditional adductor canal block; NVM (nerve to vastus medialis) targeted adductor canal block; Chloroprocaine Injection
    PhasePhase 4
    Registry statusNot yet recruiting

  • Study Comparing Several Drugs to Understand Which Work Against Cutaneous Leishmaniasis (CL)

    NCT07463040 · start 2027-01-01

    Registered record
    Registry ID
    NCT07463040
    Conditions
    Cutaneous Leihmaniasis
    Interventions
    Sodium Stibogluconate (SSG); Miltefosine; Miltefosine + Paromomycin; Liposomal Amphotericin B (LAmB); Pentamidine isethionate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2027-01-01
    Completion
    2029-08-31
    Enrolment
    900

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCutaneous Leihmaniasis
    InterventionSodium Stibogluconate (SSG); Miltefosine; Miltefosine + Paromomycin; Liposomal Amphotericin B (LAmB) +1 more
    PhasePhase 3
    Registry statusNot yet recruiting

  • Clinical Trial Evaluating the Effects of Ganaxolone in Children With Autism

    NCT07635862 · start 2027-01-01

    Registered record
    Registry ID
    NCT07635862
    Conditions
    Autism in Children; Autistic Disorder in Children and Adolescents; Autism Spectrum Disorder
    Interventions
    Ganaxolone (Ztalmy); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2027-01-01
    Completion
    2030-01-01
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutism in Children; Autistic Disorder in Children and Adolescents; Autism Spectrum Disorder
    InterventionGanaxolone (Ztalmy); Placebo
    PhasePhase 2
    Registry statusNot yet recruiting

  • Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation)

    NCT07706075 · start 2027-01-01

    Registered record
    Registry ID
    NCT07706075
    Conditions
    Atrial Fibrillation (AF); Atrial Fibrillation With Rapid Ventricular Response
    Interventions
    Verapamil Hydrochloride; Metoprolol tartrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2027-01-01
    Completion
    2027-08-01
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation (AF); Atrial Fibrillation With Rapid Ventricular Response
    InterventionVerapamil Hydrochloride; Metoprolol tartrate
    PhasePhase 4
    Registry statusNot yet recruiting

  • Study of Monzosertib In Patients With R/R AML Or High-Risk Myelodysplastic Syndrome

    NCT07780565 · start 2027-01-01

    Registered record
    Registry ID
    NCT07780565
    Conditions
    Acute Myeloid Leukemia (AML); Myelodysplastic Syndrome
    Interventions
    Monzosertib; Posaconazole; Isavuconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Not yet recruiting
    Start
    2027-01-01
    Completion
    2031-08-30
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Myeloid Leukemia (AML); Myelodysplastic Syndrome
    InterventionMonzosertib; Posaconazole; Isavuconazole
    PhasePhase 1
    Registry statusNot yet recruiting

  • Alb-PRF as an Adjunct to Regenerative Periodontal Surgery

    NCT07805317 · start 2027-01-01

    Registered record
    Registry ID
    NCT07805317
    Conditions
    Periodontitis; Periodontitis Stage III; Periodontal Intrabony Defects
    Interventions
    Regenerative Periodontal Surgery With EDTA and Allogeneic Bone Graft; Albumin Platelet-Rich Fibrin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2027-01-01
    Completion
    2028-09-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis; Periodontitis Stage III; Periodontal Intrabony Defects
    InterventionRegenerative Periodontal Surgery With EDTA and Allogeneic Bone Graft; Albumin Platelet-Rich Fibrin
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer

    NCT07820358 · start 2027-01-01

    Registered record
    Registry ID
    NCT07820358
    Conditions
    Endometrial Atypical Hyperplasia; Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia; Endometrial Cancer Stage I; Endometrial Cancer; Fertility-Sparing Treatment (FST); Obesity & Overweight
    Interventions
    Semaglutide (Wegovy) weekly injection; LNG-IUD (Progestin); Structured Weight Loss Program
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2027-01-01
    Completion
    2031-12-31
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometrial Atypical Hyperplasia; Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia; Endometrial Cancer Stage I; Endometrial Cancer +2 more
    InterventionSemaglutide (Wegovy) weekly injection; LNG-IUD (Progestin); Structured Weight Loss Program
    PhasePhase 2
    Registry statusNot yet recruiting

  • Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine

    NCT07826910 · start 2027-01-01

    Registered record
    Registry ID
    NCT07826910
    Conditions
    Migraine Disorders, Brain; Healthy Adult Participants; Vestibulo-Ocular Reflex
    Interventions
    Atogepant 60 mg; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2027-01-01
    Completion
    2028-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine Disorders, Brain; Healthy Adult Participants; Vestibulo-Ocular Reflex
    InterventionAtogepant 60 mg; Placebo
    PhasePhase 4
    Registry statusNot yet recruiting

  • Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform

    NCT01777919 · start 2027-01

    Registered record
    Registry ID
    NCT01777919
    Conditions
    Glioblastoma Multiforme
    Interventions
    Temozolomide; Disulfiram; Copper
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2027-01
    Completion
    2030-01
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlioblastoma Multiforme
    InterventionTemozolomide; Disulfiram; Copper
    PhasePhase 2
    Registry statusNot yet recruiting

  • The Dose Finding Study of DAOIB Added to tDCS for AD

    NCT05006781 · start 2027-01

    Registered record
    Registry ID
    NCT05006781
    Conditions
    Transcranial Direct Current Stimulation; Dementia
    Interventions
    DAOIB
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Suspended
    Start
    2027-01
    Completion
    2028-12
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTranscranial Direct Current Stimulation; Dementia
    InterventionDAOIB
    PhasePhase 2
    Registry statusSuspended

  • A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

    NCT05793567 · start 2027-01

    Registered record
    Registry ID
    NCT05793567
    Conditions
    Myocardial Infarction; Coronary Microvascular Disease
    Interventions
    Coronary angiogram with coronary reactivity testing (CRT)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2027-01
    Completion
    2028-01
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyocardial Infarction; Coronary Microvascular Disease
    InterventionCoronary angiogram with coronary reactivity testing (CRT)
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Vitamin C and Hiprex in rUTI

    NCT06710899 · start 2027-01

    Registered record
    Registry ID
    NCT06710899
    Conditions
    Urinary Tract Infections
    Interventions
    Methenamine Hippurate 1g BD; Methenamine Hippurate 1g BD + Vitamin C 1g BD
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Not yet recruiting
    Start
    2027-01
    Completion
    2028-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionMethenamine Hippurate 1g BD; Methenamine Hippurate 1g BD + Vitamin C 1g BD
    PhaseEarly phase 1
    Registry statusNot yet recruiting

  • National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial

    NCT07131306 · start 2027-01

    Registered record
    Registry ID
    NCT07131306
    Conditions
    Acute-On-Chronic Liver Failure
    Interventions
    ucMSC and Standard medical treatment; Standard medical treatment
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2027-01
    Completion
    2031-08
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute-On-Chronic Liver Failure
    InterventionucMSC and Standard medical treatment; Standard medical treatment
    PhasePhase 2
    Registry statusNot yet recruiting

  • Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO

    NCT07499037 · start 2027-01

    Registered record
    Registry ID
    NCT07499037
    Conditions
    Pneumonia; Heart Failure
    Interventions
    Low anticoagulation dose of argatroban and enoxaparin during ECMO; Standard anticoagulation dose of argatroban and enoxaparin during ECMO
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2027-01
    Completion
    2029-12
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia; Heart Failure
    InterventionLow anticoagulation dose of argatroban and enoxaparin during ECMO; Standard anticoagulation dose of argatroban and enoxaparin during ECMO
    PhasePhase 2
    Registry statusNot yet recruiting

  • A Study of Topical Duvelisib in Participants With Early-stage Mycosis Fungoides

    NCT07714187 · start 2027-01

    Registered record
    Registry ID
    NCT07714187
    Conditions
    Mycosis Fungoides; Cutaneous T-cell Lymphoma
    Interventions
    Duvelisib
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Not yet recruiting
    Start
    2027-01
    Completion
    2029-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMycosis Fungoides; Cutaneous T-cell Lymphoma
    InterventionDuvelisib
    PhasePhase 1
    Registry statusNot yet recruiting

AI-predicted activity is a model’s estimate that a molecule is active against a pathogen in the laboratory. It is not clinical effectiveness. The models describe each pathogen species; the data behind them rarely records resistant strains.