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AMR Drug RepurposingSmart Screeningresearch prototype

Research dashboard

Search approved medicines for AI-predicted activity against four drug-resistant pathogens, and see what evidence is already documented for each one.

TryTuberculosisMRSAKlebsiella infectionE. coli infection

1,761

Approved medicines

Approved medicines matched to the FDA Orange Book, antimicrobials included

1,276

Medicines with ≥40% AI-predicted activity

Against at least one of the four supported pathogens; each medicine counted once

1,019

Repurposing candidates

Of those, the medicines that are not already antimicrobials

How the repurposing candidates are counted

  1. 1,761approved medicines

  2. 1,276with AI-predicted activity ≥40% against at least one pathogen

    − 485 below ≥40%, not counted

  3. 1,120not already antimicrobials

    − 156 already antimicrobials, set aside

  4. 1,019repurposing candidates

    − 101 needing review, kept in the library

Existing antimicrobials are identified from WHO ATC codes and FDA pharmacologic classes. Medicines needing review (neither source says whether they are antimicrobials) stay in the approved-medicine download, marked “unclassified”. They are not assumed to be non-antimicrobials, so they are not counted as candidates.

Downloads

Download approved medicines (CSV)1,761 rowsDownload repurposing candidates (CSV)1,019 rows

Pathogen coverage

A medicine can count under more than one

Registered studies

A registration describes a study; it does not establish a positive result.

Condition
When these studies started38,873 of 39,548 have a start date · most in 2021 (1,903)
193119812030

  • Assessing Role of Probiotics in Children Aged 6-36 Months Treated for Pneumonia

    NCT07399717 · start 2026-11-01

    Registered record
    Registry ID
    NCT07399717
    Conditions
    Pneumonia; Pneumonia in Children
    Interventions
    Placebo; Navax; Navax-PregMom
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2027-12-30
    Enrolment
    330

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia; Pneumonia in Children
    InterventionPlacebo; Navax; Navax-PregMom
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Precision T1D Platform - New Therapies for Cardio-Renal Complications

    NCT07594145 · start 2026-11-01

    Registered record
    Registry ID
    NCT07594145
    Conditions
    Type 1 Diabetes; T1D Heart Failure; Cardio-renal Vascular Function and Failure; Diabetic Chronic Kidney Disease
    Interventions
    Finerenone; Sotagliflozin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2031-12-31
    Enrolment
    57

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 1 Diabetes; T1D Heart Failure; Cardio-renal Vascular Function and Failure; Diabetic Chronic Kidney Disease
    InterventionFinerenone; Sotagliflozin
    PhasePhase 2
    Registry statusNot yet recruiting

  • Vonoprazan High-Dose Dual VS Levofloxacin Concomitant

    NCT07624422 · start 2026-11-01

    Registered record
    Registry ID
    NCT07624422
    Conditions
    Helicobacter Pylori Infection; Peptic Ulcer Disease; Gastritis
    Interventions
    Vonoprazan; Levofloxacin 500mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2027-12-31
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection; Peptic Ulcer Disease; Gastritis
    InterventionVonoprazan; Levofloxacin 500mg
    PhasePhase 4
    Registry statusNot yet recruiting

  • Discontinuation Versus Continuation of Riociguat Monotherapy in Chronic Thromboembolic Pulmonary Hypertension Successfully Treated With Balloon Pulmonary Angioplasty

    NCT07644377 · start 2026-11-01

    Registered record
    Registry ID
    NCT07644377
    Conditions
    CTEPH
    Interventions
    Discontinuation of riociguat
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2031-01-31
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCTEPH
    InterventionDiscontinuation of riociguat
    PhasePhase 3
    Registry statusNot yet recruiting

  • The AYA Oncology Self-care Movement

    NCT07724652 · start 2026-11-01

    Registered record
    Registry ID
    NCT07724652
    Conditions
    Acute Lymphobkastic Leukemia; Medication Adherence
    Interventions
    Educational Website; #AYAOSM
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2030-08
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lymphobkastic Leukemia; Medication Adherence
    InterventionEducational Website; #AYAOSM
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1 Therapy Discontinuation

    NCT07729332 · start 2026-11-01

    Registered record
    Registry ID
    NCT07729332
    Conditions
    Obesity
    Interventions
    Phentermine Pill; Orforglipron
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2031-07-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionPhentermine Pill; Orforglipron
    PhasePhase 4
    Registry statusNot yet recruiting

  • ONE-P TMS First Responders

    NCT07773935 · start 2026-11-01

    Registered record
    Registry ID
    NCT07773935
    Conditions
    PTSD - Post Traumatic Stress Disorder
    Interventions
    D-Cycloserine (DCS); Placebo; Intermittent Theta Burst Stimulation (iTBS)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2029-01-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPTSD - Post Traumatic Stress Disorder
    InterventionD-Cycloserine (DCS); Placebo; Intermittent Theta Burst Stimulation (iTBS)
    PhasePhase 2
    Registry statusNot yet recruiting

  • Alternating Chemo-immunotherapy and FGFR Inhibitor for FGFR-positive Biliary or Cholangiocarcinoma

    NCT07780838 · start 2026-11-01

    Registered record
    Registry ID
    NCT07780838
    Conditions
    Locally Advanced Ampulla of Vater Carcinoma; Locally Advanced Biliary Tract Carcinoma; Locally Advanced Extrahepatic Cholangiocarcinoma; Locally Advanced Gallbladder Carcinoma; Locally Advanced Intrahepatic Cholangiocarcinoma; Metastatic Ampulla of Vater Carcinoma; Metastatic Biliary Tract Carcinoma; Metastatic Extrahepatic Cholangiocarcinoma; Metastatic Gallbladder Carcinoma; Metastatic Intrahepatic Cholangiocarcinoma; Stage III Ampulla of Vater Cancer AJCC v8; Stage III Distal Bile Duct Cancer AJCC v8; Stage III Gallbladder Cancer AJCC v8; Stage III Intrahepatic Cholangiocarcinoma AJCC v8; Stage IV Ampulla of Vater Cancer AJCC v8; Stage IV Distal Bile Duct Cancer AJCC v8; Stage IV Gallbladder Cancer AJCC v8; Stage IV Intrahepatic Cholangiocarcinoma AJCC v8; Unresectable Ampulla of Vater Carcinoma; Unresectable Biliary Tract Carcinoma; Unresectable Extrahepatic Cholangiocarcinoma; Unresectable Gallbladder Carcinoma; Unresectable Intrahepatic Cholangiocarcinoma
    Interventions
    Biospecimen Collection; Cisplatin; Computed Tomography; Durvalumab; Gemcitabine; Magnetic Resonance Imaging; Pemigatinib; Survey Administration
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2026-11-01
    Completion
    2027-12-31
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLocally Advanced Ampulla of Vater Carcinoma; Locally Advanced Biliary Tract Carcinoma; Locally Advanced Extrahepatic Cholangiocarcinoma; Locally Advanced Gallbladder Carcinoma +19 more
    InterventionBiospecimen Collection; Cisplatin; Computed Tomography; Durvalumab +4 more
    PhasePhase 2
    Registry statusRecruiting

  • Cangrelor As Treatment for Cardiac Surgery Associated With Heparin Induced Thrombocytopenia

    NCT07817680 · start 2026-11-01

    Registered record
    Registry ID
    NCT07817680
    Conditions
    Heparin-induced Thrombocytopenia
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2028-02-01
    Enrolment
    132

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeparin-induced Thrombocytopenia
    InterventionNot recorded
    PhaseNot recorded
    Registry statusNot yet recruiting

  • CannaRiver CBD Calm for Anxiety, Sleep, and Well-Being in Adults With Generalized Anxiety Disorder

    NCT07821840 · start 2026-11-01

    Registered record
    Registry ID
    NCT07821840
    Conditions
    Generalized Anxiety Disorder
    Interventions
    Cannabidiol (CBD) With Cannabinol (CBN) and Cannabigerol (CBG) Oral Tincture (CannaRiver CBD Calm)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2027-04-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneralized Anxiety Disorder
    InterventionCannabidiol (CBD) With Cannabinol (CBN) and Cannabigerol (CBG) Oral Tincture (CannaRiver CBD Calm)
    PhaseNot applicable
    Registry statusNot yet recruiting

  • A Study of Itraconazole and Posaconazole for Chronic Pulmonary Aspergillosis

    NCT07825259 · start 2026-11-01

    Registered record
    Registry ID
    NCT07825259
    Conditions
    Chronic Pulmonary Aspergillosis
    Interventions
    Posaconazole Delayed Release Oral Tablet; Itraconazole (ITZ)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2029-12-31
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Pulmonary Aspergillosis
    InterventionPosaconazole Delayed Release Oral Tablet; Itraconazole (ITZ)
    PhasePhase 3
    Registry statusNot yet recruiting

  • PREterm Infants With Bronchial Obstruction - Prospective Study of Efficacy and Safety of Inhaled Tiotropium

    NCT07827859 · start 2026-11-01

    Registered record
    Registry ID
    NCT07827859
    Conditions
    Bronchial Obstruction; Premature Birth
    Interventions
    tiotropium bromide (Spiriva Respimat)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-11-01
    Completion
    2029-08-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchial Obstruction; Premature Birth
    Interventiontiotropium bromide (Spiriva Respimat)
    PhasePhase 4
    Registry statusNot yet recruiting

  • Liposomal Amphotericin B and Flucytosine Antifungal Strategy for Talaromycosis (LAmB-FAST)

    NCT06525389 · start 2026-11

    Registered record
    Registry ID
    NCT06525389
    Conditions
    Talaromycosis
    Interventions
    Liposomal Amphotericin B (LAmB); Flucytosine (5FC); Flucytosine (5FC) placebo pill; Deoxycholate Amphotericin B (DAmB)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-11
    Completion
    2031-09-01
    Enrolment
    428

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTalaromycosis
    InterventionLiposomal Amphotericin B (LAmB); Flucytosine (5FC); Flucytosine (5FC) placebo pill; Deoxycholate Amphotericin B (DAmB)
    PhasePhase 3
    Registry statusNot yet recruiting

  • To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)

    NCT07116473 · start 2026-11

    Registered record
    Registry ID
    NCT07116473
    Conditions
    Amyloidosis in Transthyretin (TTR); Amyloidosis, Familial; Amyloid Cardiomyopathy; Amyloid Cardiomyopathy, Transthyretin-Related; Amyloidogenic Transthyretin (ATTR) Amyloidosis; Heart Disease; Cardiomyopathies; Amyloidosis, Hereditary, Transthyretin-Related; Polyneuropathies; Amyloidosis
    Interventions
    Acoramidis (AG10)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-11
    Completion
    2037-12
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAmyloidosis in Transthyretin (TTR); Amyloidosis, Familial; Amyloid Cardiomyopathy; Amyloid Cardiomyopathy, Transthyretin-Related +6 more
    InterventionAcoramidis (AG10)
    PhasePhase 3
    Registry statusNot yet recruiting

  • Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)

    NCT07206849 · start 2026-11

    Registered record
    Registry ID
    NCT07206849
    Conditions
    High Grade Glioma (HGG) of the Brain With BRAF Aberration; High Grade Glioma (III or IV); Diffuse Intrinsic Pontine Glioma; High Grade Glioma; WHO Grade 3 Glioma; WHO Grade 4 Glioma; Metastatic Brain Tumor
    Interventions
    Tovorafenib
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-11
    Completion
    2037-11
    Enrolment
    79

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh Grade Glioma (HGG) of the Brain With BRAF Aberration; High Grade Glioma (III or IV); Diffuse Intrinsic Pontine Glioma; High Grade Glioma +3 more
    InterventionTovorafenib
    PhasePhase 2
    Registry statusNot yet recruiting

AI-predicted activity is a model’s estimate that a molecule is active against a pathogen in the laboratory. It is not clinical effectiveness. The models describe each pathogen species; the data behind them rarely records resistant strains.