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AMR Drug RepurposingSmart Screeningresearch prototype

Diazepam

FDA-approved product (tablet, oral), marketed as Diastat, Diastat Acudial, Diazepam and 6 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Diazepam
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Agitation
  • Anxiety
  • Anxiety disorder
  • Cerebral palsy
  • Epilepsy
  • Stiff-Person syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Benzodiazepine derivatives
FDA pharmacologic class
Benzodiazepine FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA49.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli27.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Diazepam in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-5.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-5.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Diazepam with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Impact of Diazepam 1% Oral Gel Efficacy in Burning Mouth Syndrome

    NCT05872789 · start 2020-05-02

    Registered record
    Registry ID
    NCT05872789
    Conditions
    Burning Mouth Syndrome
    Interventions
    Diazepam 1% oral gel; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-05-02
    Completion
    2023-10-20
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurning Mouth Syndrome
    InterventionDiazepam 1% oral gel; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Impact of Placement of a Diazepam Suppository on Early Postoperative Pain Following Pelvic Reconstructive Surgery

    NCT04198233 · start 2020-02-12

    Registered record
    Registry ID
    NCT04198233
    Conditions
    Postoperative Pain
    Interventions
    Diazepam; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2020-02-12
    Completion
    2022-12
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionDiazepam; Placebos
    PhasePhase 4
    Registry statusUnknown

  • Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk

    NCT06190483 · start 2019-07-24

    Registered record
    Registry ID
    NCT06190483
    Conditions
    Prodromal Schizophrenia
    Interventions
    Diazepam 5 Mg Oral Tablet; Ascorbic Acid 50 Mg Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-07-24
    Completion
    2023-03-24
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProdromal Schizophrenia
    InterventionDiazepam 5 Mg Oral Tablet; Ascorbic Acid 50 Mg Oral Tablet
    PhaseNot applicable
    Registry statusCompleted

  • Nonopioid Analgesia After Rotator Cuff Repair

    NCT03818919 · start 2019-01-22

    Registered record
    Registry ID
    NCT03818919
    Conditions
    Rotator Cuff Tear
    Interventions
    Celecoxib; Ketorolac; Gabapentin; Acetaminophen; Diazepam; Hydrocodone-Acetaminophen
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2019-01-22
    Completion
    2020-12-31
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Tear
    InterventionCelecoxib; Ketorolac; Gabapentin; Acetaminophen +2 more
    PhasePhase 2
    Registry statusCompleted

  • Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction

    NCT03818932 · start 2019-01-22

    Registered record
    Registry ID
    NCT03818932
    Conditions
    Anterior Cruciate Ligament Injury
    Interventions
    Celecoxib; Hydrocodone-Acetaminophen; Ketorolac; Gabapentin; Acetaminophen; Diazepam
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2019-01-22
    Completion
    2020-05-20
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnterior Cruciate Ligament Injury
    InterventionCelecoxib; Hydrocodone-Acetaminophen; Ketorolac; Gabapentin +2 more
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Baclofen/Diazepam Supps for Treatment of Pelvic Floor Myalgia

    NCT03427216 · start 2018-09-01

    Registered record
    Registry ID
    NCT03427216
    Conditions
    Pelvic Floor Dyssynergia
    Interventions
    Baclofen/diazepam; Vaginal placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-09-01
    Completion
    2018-12-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPelvic Floor Dyssynergia
    InterventionBaclofen/diazepam; Vaginal placebo
    PhaseNot applicable
    Registry statusUnknown

  • Seizure Rescue Medication: Caregiver Education in a Simulation Setting

    NCT03562351 · start 2018-07-01

    Registered record
    Registry ID
    NCT03562351
    Conditions
    Status Epilepticus
    Interventions
    Verbal Instructions Educational Intervention; Video Educational Intervention; Mannequin Educational Intervention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-07-01
    Completion
    2019-09-17
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStatus Epilepticus
    InterventionVerbal Instructions Educational Intervention; Video Educational Intervention; Mannequin Educational Intervention
    PhaseNot applicable
    Registry statusCompleted

  • Oral Olanzapine Versus Haloperidol or Diazepam

    NCT03246620 · start 2017-09-01

    Registered record
    Registry ID
    NCT03246620
    Conditions
    Acute Agitation; Behavioural Emergency
    Interventions
    Olanzapine oro-dispersible 5Mg Tab; Haloperidol 2Mg encapsulated Tab; Diazepam 2Mg encapsulated Tab
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-09-01
    Completion
    2018-06-01
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Agitation; Behavioural Emergency
    InterventionOlanzapine oro-dispersible 5Mg Tab; Haloperidol 2Mg encapsulated Tab; Diazepam 2Mg encapsulated Tab
    PhasePhase 4
    Registry statusTerminated

  • Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients

    NCT03088306 · start 2017-07-01

    Registered record
    Registry ID
    NCT03088306
    Conditions
    Lumbar Spinal Stenosis; Lumbar Spinal Instability; Lumbar Spine Degeneration
    Interventions
    Standard analgesia use [Oxygen]; Standard analgesia use [Hydromorphone]; Standard analgesia use [Volatile Anesthesia]; Standard analgesia use [Fentanyl]; Multi-modal pain management [Acetaminophen + Gabapentin]; Multi-modal pain management [Fentanyl]; Multi-modal pain management [Intravenous Ketamine]; Multi-modal pain management [Valium + Gabapentin]
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2017-07-01
    Completion
    2018-08-31
    Enrolment
    49

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLumbar Spinal Stenosis; Lumbar Spinal Instability; Lumbar Spine Degeneration
    InterventionStandard analgesia use [Oxygen]; Standard analgesia use [Hydromorphone]; Standard analgesia use [Volatile Anesthesia]; Standard analgesia use [Fentanyl] +4 more
    PhaseEarly phase 1
    Registry statusCompleted

  • Study of Diazepam Buccal Film Administered in the Interictal and in the Ictal-Periictal States to Adults With Epilepsy

    NCT03179891 · start 2017-05-25

    Registered record
    Registry ID
    NCT03179891
    Conditions
    Epilepsy
    Interventions
    Diazepam Buccal Film 12.5 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-05-25
    Completion
    2018-12-21
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionDiazepam Buccal Film 12.5 mg
    PhasePhase 2
    Registry statusCompleted

  • Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures

    NCT03631901 · start 2017-04-01

    Registered record
    Registry ID
    NCT03631901
    Conditions
    Febrile Seizures
    Interventions
    oral melatonin; oral diazepam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-04-01
    Completion
    2018-09-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFebrile Seizures
    Interventionoral melatonin; oral diazepam
    PhasePhase 4
    Registry statusCompleted

  • Intrathecal Dexmedetomidine Versus Fentanyl With Bupivacaine in Children Undergoing Major Abdominal Cancer Surgery

    NCT02861716 · start 2016-08

    Registered record
    Registry ID
    NCT02861716
    Conditions
    Intrathecal Dexmedetomidine; Pediatric Cancer Surgery
    Interventions
    Bupivacaine; Fentanyl; Dexmedetomidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2016-08
    Completion
    2019-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntrathecal Dexmedetomidine; Pediatric Cancer Surgery
    InterventionBupivacaine; Fentanyl; Dexmedetomidine
    PhasePhase 2
    Registry statusUnknown

  • Sensitivity of Project: EVO Monitor Cognitive Measurements to Pharmacological Agents

    NCT02822937 · start 2016-07

    Registered record
    Registry ID
    NCT02822937
    Conditions
    Healthy
    Interventions
    Methylphenidate; Triazolam; Project: EVO; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-07
    Completion
    2016-11
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionMethylphenidate; Triazolam; Project: EVO; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Baclofen in Managing Acute Alcohol Withdrawal

    NCT03293017 · start 2016-02-01

    Registered record
    Registry ID
    NCT03293017
    Conditions
    Alcohol Use Disorder; Alcohol Withdrawal
    Interventions
    Diazepam 10 MG; Baclofen 30mg; Baclofen 60mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-02-01
    Completion
    2022-02-01
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcohol Use Disorder; Alcohol Withdrawal
    InterventionDiazepam 10 MG; Baclofen 30mg; Baclofen 60mg
    PhasePhase 4
    Registry statusUnknown

  • Fixed-schedule Benzodiazepine Dosing vs Based on a CIWA-Ar Alcohol Protocol in Alcohol Detoxification.

    NCT04777552 · start 2015-10

    Registered record
    Registry ID
    NCT04777552
    Conditions
    Alcoholdependence; CIWA-R; Benzodiazepines
    Interventions
    diazepam (or equivalence if other benzodiazepine)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-10
    Completion
    2016-05
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholdependence; CIWA-R; Benzodiazepines
    Interventiondiazepam (or equivalence if other benzodiazepine)
    PhaseNot recorded
    Registry statusCompleted