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AMR Drug RepurposingSmart Screeningresearch prototype

Diazepam

FDA-approved product (tablet, oral), marketed as Diastat, Diastat Acudial, Diazepam and 6 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Diazepam
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Agitation
  • Anxiety
  • Anxiety disorder
  • Cerebral palsy
  • Epilepsy
  • Stiff-Person syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Benzodiazepine derivatives
FDA pharmacologic class
Benzodiazepine FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA49.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli27.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Diazepam in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-5.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-5.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Diazepam with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Measuring Pelvic Floor Muscle Fitness Before and After Treatment

    NCT07605598 · start 2026-09-01

    Registered record
    Registry ID
    NCT07605598
    Conditions
    Myofacial Pain; Pelvic Pain; Myofascial Pelvic Pain; Chronic Pelvic Pain
    Interventions
    Near Infrared Imaging
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-09-01
    Completion
    2029-07-01
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyofacial Pain; Pelvic Pain; Myofascial Pelvic Pain; Chronic Pelvic Pain
    InterventionNear Infrared Imaging
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis.

    NCT05270434 · start 2025-03-12

    Registered record
    Registry ID
    NCT05270434
    Conditions
    Pancreatitis, Chronic
    Interventions
    time interval between ESWL and ERCP is 12h; time interval between ESWL and ERCP is greater than 12h; morphine, buprenorphine, pethidine, tramaldol, metamizole and acetylsalicylacid (Analgesics)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-03-12
    Completion
    2025-10-20
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPancreatitis, Chronic
    Interventiontime interval between ESWL and ERCP is 12h; time interval between ESWL and ERCP is greater than 12h; morphine, buprenorphine, pethidine, tramaldol, metamizole and acetylsalicylacid (Analgesics)
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Febrile Convulsion Training on Anxiety and Knowledge

    NCT06676020 · start 2024-11-30

    Registered record
    Registry ID
    NCT06676020
    Conditions
    Febrile Convulsion
    Interventions
    Nurse-delivered structured education
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-11-30
    Completion
    2025-11-30
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFebrile Convulsion
    InterventionNurse-delivered structured education
    PhaseNot applicable
    Registry statusCompleted

  • Evaluating Bone Marrow Cell Transplant for Treating Cerebral Palsy From Brain Hypoxia

    NCT06629324 · start 2024-10-15

    Registered record
    Registry ID
    NCT06629324
    Conditions
    Autism Spectrum Disorder
    Interventions
    Autologous Bone Marrow Mononuclear Cell Transfusion; Rehabilitation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2024-10-15
    Completion
    2027-01-31
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutism Spectrum Disorder
    InterventionAutologous Bone Marrow Mononuclear Cell Transfusion; Rehabilitation
    PhasePhase 2
    Registry statusRecruiting

  • Efficacy and Safety of Intravenous Diazepam Given at 2 Different Doses Compared to Placebo in Acute Peripheral Vertigo

    NCT06293989 · start 2024-05-01

    Registered record
    Registry ID
    NCT06293989
    Conditions
    Vertigo, Peripheral
    Interventions
    Diazepam 5mg; Diazepam 10 mg; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2024-05-01
    Completion
    2026-03-30
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVertigo, Peripheral
    InterventionDiazepam 5mg; Diazepam 10 mg; Placebo
    PhasePhase 3
    Registry statusUnknown

  • Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy

    NCT06298227 · start 2024-03-11

    Registered record
    Registry ID
    NCT06298227
    Conditions
    Kidney Diseases; Kidney Failure
    Interventions
    Postoperative analgesia management with Paracerol® and IV PCA with Talinat®; Erector spinae plane block; Quadratus lumborum plane block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-03-11
    Completion
    2026-01-30
    Enrolment
    62

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Diseases; Kidney Failure
    InterventionPostoperative analgesia management with Paracerol® and IV PCA with Talinat®; Erector spinae plane block; Quadratus lumborum plane block
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Hydroxyzine for Patients With Panic Disorder

    NCT05737511 · start 2023-12-30

    Registered record
    Registry ID
    NCT05737511
    Conditions
    Panic Disorder
    Interventions
    Hydroxyzine; Escitalopram Oxalate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2023-12-30
    Completion
    2026-12-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPanic Disorder
    InterventionHydroxyzine; Escitalopram Oxalate
    PhasePhase 4
    Registry statusNot yet recruiting

  • Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively

    NCT06103188 · start 2023-10-02

    Registered record
    Registry ID
    NCT06103188
    Conditions
    Anxiety; Preoperative Anxiety
    Interventions
    Placebo; Diazepam; Melatonin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2023-10-02
    Completion
    2023-10-30
    Enrolment
    87

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety; Preoperative Anxiety
    InterventionPlacebo; Diazepam; Melatonin
    PhasePhase 3
    Registry statusCompleted

  • Virtual Reality to Reduce Periprocedural Anxiety During Invasive Coronary Angiography

    NCT06215456 · start 2023-09-18

    Registered record
    Registry ID
    NCT06215456
    Conditions
    Anxiety; Anxiety State
    Interventions
    Virtual reality therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-09-18
    Completion
    2024-04-30
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety; Anxiety State
    InterventionVirtual reality therapy
    PhaseNot applicable
    Registry statusUnknown

  • Observational Retrospective Study on Spinal Analgesia in Laparoscopic and Laparotomic Hysterectomy

    NCT05654363 · start 2023-03-13

    Registered record
    Registry ID
    NCT05654363
    Conditions
    Pain, Postoperative; Hysterectomy; Morphine; Anesthesia, Spinal
    Interventions
    Administration of morphine by intrathecal route; Administration of morphine by intravenous route
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2023-03-13
    Completion
    2023-06-01
    Enrolment
    670

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative; Hysterectomy; Morphine; Anesthesia, Spinal
    InterventionAdministration of morphine by intrathecal route; Administration of morphine by intravenous route
    PhaseNot recorded
    Registry statusCompleted

  • Effectiveness of Conventional Therapy Plus Pulsed-Radiofrequency for Herniated Nucleus Pulposus

    NCT06415331 · start 2023-02-02

    Registered record
    Registry ID
    NCT06415331
    Conditions
    Herniated Nucleus Pulposus; Pain
    Interventions
    Pulsed radiofrequency; Conventional therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-02-02
    Completion
    2023-09-16
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHerniated Nucleus Pulposus; Pain
    InterventionPulsed radiofrequency; Conventional therapy
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Efficacy of Basket and Balloon in the Removal of Pancreatic Duct Stones in Chronic Pancreatitis Under ERCP

    NCT05289362 · start 2022-06-15

    Registered record
    Registry ID
    NCT05289362
    Conditions
    Pancreatitis, Chronic; Pancreatic Duct Stone
    Interventions
    Basket group; Balloon group
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-06-15
    Completion
    2023-03-12
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPancreatitis, Chronic; Pancreatic Duct Stone
    InterventionBasket group; Balloon group
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of SMOF Lipid in the Management of Acute Poisoning With Clozapine

    NCT06413589 · start 2022-01-01

    Registered record
    Registry ID
    NCT06413589
    Conditions
    Acute Poisoning
    Interventions
    SMOF lipid 20%; standard treatment for clozapine toxicity
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2022-01-01
    Completion
    2023-02-28
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Poisoning
    InterventionSMOF lipid 20%; standard treatment for clozapine toxicity
    PhasePhase 2
    Registry statusCompleted

  • Pharmacokinetics Study of VALTOCO® in Pediatric Subjects With Epilepsy

    NCT05076838 · start 2021-11-08

    Registered record
    Registry ID
    NCT05076838
    Conditions
    Epilepsy
    Interventions
    Diazepam Nasal Spray [Valtoco]
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2021-11-08
    Completion
    2025-03-11
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionDiazepam Nasal Spray [Valtoco]
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Efficacy and Safety of Perampanel in Combination in Glioma-refractory Epilepsy

    NCT03636958 · start 2021-02-15

    Registered record
    Registry ID
    NCT03636958
    Conditions
    Refractory Epilepsy
    Interventions
    Perampanel; conventional antiepileptic treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2021-02-15
    Completion
    2026-12-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRefractory Epilepsy
    InterventionPerampanel; conventional antiepileptic treatment
    PhaseNot applicable
    Registry statusWithdrawn