Diazepam
FDA-approved product (tablet, oral), marketed as Diastat, Diastat Acudial, Diazepam and 6 more.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 2 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Agitation
- Anxiety
- Anxiety disorder
- Cerebral palsy
- Epilepsy
- Stiff-Person syndrome
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Benzodiazepine derivatives
- FDA pharmacologic class
- Benzodiazepine FDA label ↗
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA49.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli27.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae17.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis57.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Diazepam with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- FurazolidoneExisting use: Other antiinfectives and antiseptics91.4% AI-predicted activityagainst M. tuberculosisLab records exist49 registered studies
- TriflupromazineExisting use: Psychosis90.6% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- ValdecoxibExisting use: Dysmenorrhea, Osteoarthritis, Rheumatic disease and 1 more88.6% AI-predicted activityagainst M. tuberculosisLab records exist31 registered studies
- CelecoxibExisting use: Ankylosing spondylitis, Cancer, Colorectal neoplasm and 15 more87.6% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Dorzolamide HydrochlorideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma86.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- MethazolamideExisting use: Glaucoma, Open-angle glaucoma85.6% AI-predicted activityagainst M. tuberculosisLab records exist11 registered studies
- AcetazolamideExisting use: Altitude sickness, Angle-closure glaucoma, Congestive heart failure and 5 more85.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Trifluoperazine HydrochlorideExisting use: Anxiety disorder, Mental or behavioural disorder, Psychosis and 1 more84.6% AI-predicted activityagainst M. tuberculosis1 registered study
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives84.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- NitrofurazoneExisting use: Eye infection, Leishmaniasis, Trypanosomiasis84.0% AI-predicted activityagainst M. tuberculosis8 registered studies
- BrinzolamideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma83.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- ZonisamideExisting use: Epilepsy, Focal-onset seizure, Partial epilepsy and 1 more82.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients
NCT00641797 · start 2006-11
Registered record
- Registry ID
- NCT00641797
- Conditions
- Benign Paroxysmal Positional Vertigo
- Interventions
- Meclizine; Epley Maneuver; Lorazepam; Diphenhydramine; Ondansetron
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2006-11
- Completion
- 2013-11
- Enrolment
- 26
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionBenign Paroxysmal Positional VertigoInterventionMeclizine; Epley Maneuver; Lorazepam; Diphenhydramine +1 morePhaseNot applicableRegistry statusCompletedIntranasal Midazolam Versus Rectal Diazepam for Treatment of Seizures
NCT00326612 · start 2006-06
Registered record
- Registry ID
- NCT00326612
- Conditions
- Seizures
- Interventions
- Midazolam; Diazepam
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2006-06
- Completion
- 2008-12
- Enrolment
- 358
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSeizuresInterventionMidazolam; DiazepamPhasePhase 2Registry statusCompletedExcessive Crying in Children With Cerebral Palsy and Communication Deficits
NCT04523935 · start 2005-12-07
Registered record
- Registry ID
- NCT04523935
- Conditions
- Cerebral Palsy; Excessive Crying; Pain
- Interventions
- Placebo; Baclofen, Diazepam, Clonazepam, Trihexyphenidyl, Tetrabenazine, Gabapentin, Topiramate, Lamotrigine, Amitriptyline.
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2005-12-07
- Completion
- 2020-08-04
- Enrolment
- 131
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCerebral Palsy; Excessive Crying; PainInterventionPlacebo; Baclofen, Diazepam, Clonazepam, Trihexyphenidyl, Tetrabenazine, Gabapentin, Topiramate, Lamotrigine, Amitriptyline.PhasePhase 4Registry statusCompletedComparison Between Nurse-Administered Propofol Sedation and Diazemuls / Pethidine in Outpatient Colonoscopy
NCT00566683 · start 2005-07
Registered record
- Registry ID
- NCT00566683
- Conditions
- Colonoscopy
- Interventions
- diazemuls, pethidine; Propofol and Alfentanil
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2005-07
- Completion
- 2006-06
- Enrolment
- 194
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColonoscopyInterventiondiazemuls, pethidine; Propofol and AlfentanilPhaseNot applicableRegistry statusCompletedThe Effect of Valproate on Benzodiazepine Withdrawal Severity
NCT00570219 · start 2005-02
Registered record
- Registry ID
- NCT00570219
- Conditions
- Substance Withdrawal Syndrome
- Interventions
- valproate
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2005-02
- Completion
- 2008-05
- Enrolment
- 30
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSubstance Withdrawal SyndromeInterventionvalproatePhaseNot applicableRegistry statusCompleted