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AMR Drug RepurposingSmart Screeningresearch prototype

Ivabradine

FDA-approved product (solution, oral), marketed as Corlanor, Ivabradine Hydrochloride.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Ivabradine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Angina pectoris
  • Cardiovascular disease
  • Congestive heart failure
  • Heart failure

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other cardiac preparations
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA49.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli45.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae33.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis38.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ivabradine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ivabradine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Ivabradine in Lowering Heart Rate and Quality of Life in Chronic Heart Failure Patients

    NCT03710057 · start 2016-12-01

    Registered record
    Registry ID
    NCT03710057
    Conditions
    Chronic Heart Failure
    Interventions
    Ivabradine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-12-01
    Completion
    2017-05-15
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Heart Failure
    InterventionIvabradine
    PhaseNot recorded
    Registry statusCompleted

  • Pulse Reduction On Beta-blocker and Ivabradine Therapy

    NCT02973594 · start 2016-11

    Registered record
    Registry ID
    NCT02973594
    Conditions
    Dilated Cardiomyopathies, Idiopathic; Heart Failure, Systolic; Ventricular Remodeling; Electrical Remodeling
    Interventions
    Ivabradine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-11
    Completion
    2023-06-30
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDilated Cardiomyopathies, Idiopathic; Heart Failure, Systolic; Ventricular Remodeling; Electrical Remodeling
    InterventionIvabradine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker

    NCT03245996 · start 2015-06

    Registered record
    Registry ID
    NCT03245996
    Conditions
    Aortic Blood Pressure
    Interventions
    AAI 40 bpm; AAI 60 bpm; AAI 90 bpm; Atenolol Pill; Nebivolol Pill; Ivabradine Pill
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-06
    Completion
    2016-09
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAortic Blood Pressure
    InterventionAAI 40 bpm; AAI 60 bpm; AAI 90 bpm; Atenolol Pill +2 more
    PhasePhase 4
    Registry statusCompleted

  • Heart Rate Reducing Therapy in Cardiac CT Using Ivabradine and Bisoprolol

    NCT02764970 · start 2015-02

    Registered record
    Registry ID
    NCT02764970
    Conditions
    Bradycardia
    Interventions
    Ivabradine 7.5mg orally
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-02
    Completion
    2016-01
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBradycardia
    InterventionIvabradine 7.5mg orally
    PhaseNot recorded
    Registry statusCompleted

  • To Assess the Anti-anginal Safety and Efficacy of Ivabradine in Subjects With Stable，Symptomatic Chronic Angina

    NCT02623569 · start 2014-10

    Registered record
    Registry ID
    NCT02623569
    Conditions
    Angina Pectoris
    Interventions
    Ivabradine; Atenolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2014-10
    Completion
    2017-06
    Enrolment
    336

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAngina Pectoris
    InterventionIvabradine; Atenolol
    PhasePhase 2
    Registry statusUnknown

  • The Influence of Heart Rate Limitation on Exercise Tolerance in Pacemaker Patients.

    NCT02247245 · start 2014-09

    Registered record
    Registry ID
    NCT02247245
    Conditions
    Chronic Heart Failure; Atrial Fibrillation; Arrhythmia, Sinus
    Interventions
    Ivabradine; Atrial fibrillation; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-09
    Completion
    2015-09
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Heart Failure; Atrial Fibrillation; Arrhythmia, Sinus
    InterventionIvabradine; Atrial fibrillation; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Digoxin Versus Ivabradine in Heart Failure With Reduced Ejection Fraction

    NCT02046044 · start 2014-01

    Registered record
    Registry ID
    NCT02046044
    Conditions
    Heart Failure
    Interventions
    Digoxin; Ivabradine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-01
    Completion
    2014-10
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure
    InterventionDigoxin; Ivabradine
    PhasePhase 4
    Registry statusUnknown

  • Ivabradine Versus Beta-blockers in the Treatment of Inappropriate Sinus Tachycardia

    NCT01657136 · start 2013-09

    Registered record
    Registry ID
    NCT01657136
    Conditions
    Inappropriate Sinus Tachycardia
    Interventions
    Ivabradine; Beta blocker
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-09
    Completion
    2016-09
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInappropriate Sinus Tachycardia
    InterventionIvabradine; Beta blocker
    PhasePhase 3
    Registry statusCompleted

  • Control of Sinus Node Tachycardia as an Additional Therapy in Patients With Decompensated Heart Failure

    NCT02236247 · start 2013-05

    Registered record
    Registry ID
    NCT02236247
    Conditions
    Decompensated Heart Failure
    Interventions
    ivabradine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2013-05
    Completion
    2017-08
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDecompensated Heart Failure
    Interventionivabradine; Placebo
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure

    NCT00757055 · start 2012-12

    Registered record
    Registry ID
    NCT00757055
    Conditions
    Diastolic Heart Failure
    Interventions
    Ivabradine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2012-12
    Completion
    2014-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiastolic Heart Failure
    InterventionIvabradine; Placebo
    PhasePhase 2
    Registry statusWithdrawn

  • Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease

    NCT01768585 · start 2012-12

    Registered record
    Registry ID
    NCT01768585
    Conditions
    Coronary Artery Disease; Coronary Arteriosclerosis
    Interventions
    Ivabradine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-12
    Completion
    2014-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease; Coronary Arteriosclerosis
    InterventionIvabradine; Placebo
    PhasePhase 4
    Registry statusUnknown

  • The Role of Chronotropic Incompetence in Heart Failure With Normal Ejection Fraction (HFNEF)

    NCT02354573 · start 2011-12

    Registered record
    Registry ID
    NCT02354573
    Conditions
    Heart Failure
    Interventions
    Ivabradine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-12
    Completion
    2014-01
    Enrolment
    121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure
    InterventionIvabradine
    PhaseNot applicable
    Registry statusCompleted

  • Heart Rate Reduction in Heart Failure

    NCT01178528 · start 2009-09

    Registered record
    Registry ID
    NCT01178528
    Conditions
    Heart Failure
    Interventions
    ivabradine; "Drug:Carvedilol" and "Drug:Ivabradine"; Carvedilol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-09
    Completion
    2010-10
    Enrolment
    121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure
    Interventionivabradine; "Drug:Carvedilol" and "Drug:Ivabradine"; Carvedilol
    PhasePhase 3
    Registry statusCompleted

  • HR-lowering Efficacy and Respiratory Safety of Ivabradine in Patients With Obstructive Airway Disease

    NCT01365286 · start 2009-05

    Registered record
    Registry ID
    NCT01365286
    Conditions
    Asthma, Chronic Obstructive Pulmonary Disease (COPD)
    Interventions
    Ivabradine (Procoralan); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-05
    Completion
    2011-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma, Chronic Obstructive Pulmonary Disease (COPD)
    InterventionIvabradine (Procoralan); Placebo
    PhasePhase 4
    Registry statusCompleted

  • Effects of the Ivabradine on Reduction of Inflammatory Markers in Patients With Acute Coronary Syndrome

    NCT00815100 · start 2009-04

    Registered record
    Registry ID
    NCT00815100
    Conditions
    Acute Coronary Syndromes
    Interventions
    Ivabradine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-04
    Completion
    2011-09-07
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndromes
    InterventionIvabradine; Placebo
    PhasePhase 4
    Registry statusCompleted