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AMR Drug RepurposingSmart Screeningresearch prototype

Sodium Gluconate

FDA-approved product (injectable, injection).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Sodium Gluconate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

Anti-infective classification
Neither a WHO ATC code nor an FDA pharmacologic class was found for it, so whether it is already an antimicrobial is not established. It needs review and is not counted as a repurposing candidate.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Sodium Gluconate, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA10.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli23.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis18.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sodium Gluconate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sodium Gluconate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Chlorhexidine Gluconate Versus Mupirocin Ointment in the Prevention of Peritoneal Dialysis-Related Infection

    NCT02547103 · start 2016-06-01

    Registered record
    Registry ID
    NCT02547103
    Conditions
    End Stage Renal Disease; Peritoneal Dialysis
    Interventions
    Chlorhexidine gluconate-soaked cloths; Normal saline; mupirocin ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-06-01
    Completion
    2021-08
    Enrolment
    354

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnd Stage Renal Disease; Peritoneal Dialysis
    InterventionChlorhexidine gluconate-soaked cloths; Normal saline; mupirocin ointment
    PhasePhase 4
    Registry statusUnknown

  • Zinc Supplement in Regorafenib Treated mCRC Patient

    NCT03898102 · start 2016-03

    Registered record
    Registry ID
    NCT03898102
    Conditions
    Colorectal Cancer Metastatic
    Interventions
    Regorafenib; Zinc gluconate supplement
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-03
    Completion
    2019-03
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer Metastatic
    InterventionRegorafenib; Zinc gluconate supplement
    PhasePhase 2
    Registry statusCompleted

  • Acceptability and Feasibility of Micronutrient Powders Versus Iron Syrup for Anemia Prevention in Young Children

    NCT02610881 · start 2015-12

    Registered record
    Registry ID
    NCT02610881
    Conditions
    Anemia
    Interventions
    Iron and Folic Acid (IFA); Micronutrient Powders (MNP); Iron Plus Strategy Counseling
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-12
    Completion
    2016-04
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnemia
    InterventionIron and Folic Acid (IFA); Micronutrient Powders (MNP); Iron Plus Strategy Counseling
    PhaseNot applicable
    Registry statusCompleted

  • Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome

    NCT02513784 · start 2015-08

    Registered record
    Registry ID
    NCT02513784
    Conditions
    Esophageal Adenocarcinoma; Barrett's Esophagus; Reflux Esophagitis
    Interventions
    Chlorhexidine gluconate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-08
    Completion
    2017-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEsophageal Adenocarcinoma; Barrett's Esophagus; Reflux Esophagitis
    InterventionChlorhexidine gluconate
    PhaseNot applicable
    Registry statusCompleted

  • Chlorhexidine Bathing Effect on Clostridium Difficile Rates

    NCT02502682 · start 2015-07

    Registered record
    Registry ID
    NCT02502682
    Conditions
    Clostridium Difficile
    Interventions
    Sage 2% Chlorhexidine Gluconate Cloth Patient Preoperative Skin Preparation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-07
    Completion
    2016-06
    Enrolment
    167

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClostridium Difficile
    InterventionSage 2% Chlorhexidine Gluconate Cloth Patient Preoperative Skin Preparation
    PhasePhase 2
    Registry statusCompleted

  • Treating Parents to Reduce NICU Transmission of Staphylococcus Aureus Trial

    NCT02223520 · start 2014-11

    Registered record
    Registry ID
    NCT02223520
    Conditions
    Staph Aureus Colonization; Staph Aureus Infection
    Interventions
    Mupirocin and Chlorhexidine; Placebo ointment and placebo cloths
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-11
    Completion
    2019-10-31
    Enrolment
    307

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaph Aureus Colonization; Staph Aureus Infection
    InterventionMupirocin and Chlorhexidine; Placebo ointment and placebo cloths
    PhaseNot applicable
    Registry statusCompleted

  • Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects

    NCT02222896 · start 2014-08

    Registered record
    Registry ID
    NCT02222896
    Conditions
    Surgery
    Interventions
    Chlorhexidine Gluconate; Vehicle; DynaHex-2
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-08
    Completion
    2015-05
    Enrolment
    347

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgery
    InterventionChlorhexidine Gluconate; Vehicle; DynaHex-2
    PhasePhase 3
    Registry statusCompleted

  • The Efficacy and Safety of Chlorhexidine Gluconate Chip (PerioChip®) in Therapy of Peri-implantitis

    NCT02080403 · start 2014-07

    Registered record
    Registry ID
    NCT02080403
    Conditions
    Peri-Implantitis
    Interventions
    2.5 mg Chlorhexidine gluconate chip
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-07
    Completion
    2018-11
    Enrolment
    290

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeri-Implantitis
    Intervention2.5 mg Chlorhexidine gluconate chip
    PhasePhase 3
    Registry statusCompleted

  • In Vivo Efficacy Study of Patient Preoperative Preps

    NCT02203591 · start 2014-07

    Registered record
    Registry ID
    NCT02203591
    Conditions
    Bacterial Reduction Post-product Application
    Interventions
    3M CHG/IPA Prep C; 3M CHG/IPA Prep CH; ChloraPrep; Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-07
    Completion
    2015-03
    Enrolment
    738

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Reduction Post-product Application
    Intervention3M CHG/IPA Prep C; 3M CHG/IPA Prep CH; ChloraPrep; Normal Saline
    PhasePhase 3
    Registry statusCompleted

  • An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining

    NCT01962493 · start 2013-09

    Registered record
    Registry ID
    NCT01962493
    Conditions
    Oral Hygiene
    Interventions
    Sodium bicarbonate/ Sodium Fluoride; Sodium fluoride; Chlorhexidine digluconate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-09
    Completion
    2013-11
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Hygiene
    InterventionSodium bicarbonate/ Sodium Fluoride; Sodium fluoride; Chlorhexidine digluconate
    PhasePhase 4
    Registry statusCompleted

  • Role of Infected Blood Dendritic Cells in Heart Disease Risk

    NCT01568944 · start 2012-03

    Registered record
    Registry ID
    NCT01568944
    Conditions
    Chronic Periodontitis
    Interventions
    Oral Antibiotic and Oral Rinse; Standard Treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-03
    Completion
    2014-09
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Periodontitis
    InterventionOral Antibiotic and Oral Rinse; Standard Treatment
    PhaseNot applicable
    Registry statusCompleted

  • Study of Roxadustat (FG-4592) to Correct Anemia in Newly Initiated Dialysis Participants Not on Erythropoiesis-Stimulating Agent Treatment

    NCT01414075 · start 2011-07-21

    Registered record
    Registry ID
    NCT01414075
    Conditions
    Dialysis; Anemia
    Interventions
    Roxadustat; Oral Iron; IV Iron
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-07-21
    Completion
    2013-01-10
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDialysis; Anemia
    InterventionRoxadustat; Oral Iron; IV Iron
    PhasePhase 2
    Registry statusCompleted

  • Strategies to Reduce Iron Deficiency

    NCT02245321 · start 2011-06

    Registered record
    Registry ID
    NCT02245321
    Conditions
    Iron Deficiency
    Interventions
    Ferrous gluconate- 19 mg; Ferrous gluconate- 38 mg; Letter Group- Information Provided; Letter - No Information Provided; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-06
    Completion
    2014-06
    Enrolment
    702

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIron Deficiency
    InterventionFerrous gluconate- 19 mg; Ferrous gluconate- 38 mg; Letter Group- Information Provided; Letter - No Information Provided +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Antimicrobial Activity of IV Clear™ Dressing - Prevention of Antimicrobial Regrowth

    NCT01368120 · start 2011-04

    Registered record
    Registry ID
    NCT01368120
    Conditions
    Skin Flora Infection
    Interventions
    IV Clear™ Dressing; Tegaderm CHG™; Silicone Vehicle Control Dressing
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-04
    Completion
    2011-07
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Flora Infection
    InterventionIV Clear™ Dressing; Tegaderm CHG™; Silicone Vehicle Control Dressing
    PhasePhase 1
    Registry statusCompleted

  • Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus (MRSA) in the Outpatient Setting

    NCT01232231 · start 2010-07

    Registered record
    Registry ID
    NCT01232231
    Conditions
    Methicillin-resistant Staphylococcus Aureus
    Interventions
    pharmacological decolonization treatment; Education
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-07
    Completion
    2012-11
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus
    Interventionpharmacological decolonization treatment; Education
    PhaseNot applicable
    Registry statusCompleted