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AMR Drug RepurposingSmart Screeningresearch prototype

Sodium Gluconate

FDA-approved product (injectable, injection).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Sodium Gluconate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

Anti-infective classification
Neither a WHO ATC code nor an FDA pharmacologic class was found for it, so whether it is already an antimicrobial is not established. It needs review and is not counted as a repurposing candidate.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Sodium Gluconate, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA10.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli23.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis18.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sodium Gluconate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sodium Gluconate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Micronutrient Sprinkles in a Daycare Center

    NCT00967551 · start 2009-07

    Registered record
    Registry ID
    NCT00967551
    Conditions
    Diarrhea; Respiratory Infection
    Interventions
    Micronutrient Sprinkles with zinc; Micronutrient sprinkles without zinc
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-07
    Completion
    2012-07
    Enrolment
    143

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiarrhea; Respiratory Infection
    InterventionMicronutrient Sprinkles with zinc; Micronutrient sprinkles without zinc
    PhasePhase 3
    Registry statusCompleted

  • Phase I/II Trial of Sodium Stibogluconate in Myelodysplastic Syndrome

    NCT01009502 · start 2009-07

    Registered record
    Registry ID
    NCT01009502
    Conditions
    Myelodysplastic Syndromes
    Interventions
    sodium stibogluconate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2009-07
    Completion
    2013-05
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyelodysplastic Syndromes
    Interventionsodium stibogluconate
    PhasePhase 1
    Registry statusTerminated

  • Combined Vitamins and Minerals Decrease Incidence of Upper Respiratory Tract Infections in Older Persons

    NCT01484756 · start 2008-08

    Registered record
    Registry ID
    NCT01484756
    Conditions
    Upper Respiratory Tract Infection
    Interventions
    daily multi micronutrient supplement; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-08
    Completion
    2009-03
    Enrolment
    270

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUpper Respiratory Tract Infection
    Interventiondaily multi micronutrient supplement; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Study of Bathing With Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit

    NCT00549393 · start 2008-02

    Registered record
    Registry ID
    NCT00549393
    Conditions
    Nosocomial Infections
    Interventions
    2% Chlorhexidine gluconate cloth
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2008-02
    Completion
    2012-06
    Enrolment
    5,659

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNosocomial Infections
    Intervention2% Chlorhexidine gluconate cloth
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Serum NGAL Levels in Hemodialysis (HD) Patients; Relation to Iron Status, HD and Intravenous (IV) Iron Administration

    NCT00560976 · start 2005-12

    Registered record
    Registry ID
    NCT00560976
    Conditions
    Renal Failure Chronic Requiring Hemodialysis
    Interventions
    Iron Saccharate (Venofer)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2005-12
    Completion
    2014-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Failure Chronic Requiring Hemodialysis
    InterventionIron Saccharate (Venofer)
    PhaseNot applicable
    Registry statusUnknown