Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Betamethasone Acetate

FDA-approved product (injectable, injection).

Registered studies
27
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Betamethasone Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Anemia
  • Asthma
  • Dermatitis
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion
  • Nephrotic syndrome
  • Type III hypersensitivity reaction disease
  • Ulcerative colitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids acting locally; Corticosteroids; Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA55.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli34.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae29.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis26.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

27registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Betamethasone Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Betamethasone Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • India Dexamethasone and Betamethasone

    NCT03668860 · start 2018-09-20

    Registered record
    Registry ID
    NCT03668860
    Conditions
    Preterm Birth; Antenatal Corticosteroids
    Interventions
    Dexamethasone 4 mg/ml; Betamethasone 4 mg/ml; Celestone Soluspan 6Mg/Ml Suspension for Injection; Dexamethasone Oral Tablet; Betamethasone Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2018-09-20
    Completion
    2019-12-31
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Birth; Antenatal Corticosteroids
    InterventionDexamethasone 4 mg/ml; Betamethasone 4 mg/ml; Celestone Soluspan 6Mg/Ml Suspension for Injection; Dexamethasone Oral Tablet +1 more
    PhasePhase 1
    Registry statusCompleted

  • Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study

    NCT03707795 · start 2017-08-21

    Registered record
    Registry ID
    NCT03707795
    Conditions
    Familial Amyotrophic Lateral Sclerosis
    Interventions
    Betamethasone sodium phosphate/betamethasone acetate (Celestone® Soluspan®), 30 mg IM once a day for four days
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2017-08-21
    Completion
    2019-01-10
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFamilial Amyotrophic Lateral Sclerosis
    InterventionBetamethasone sodium phosphate/betamethasone acetate (Celestone® Soluspan®), 30 mg IM once a day for four days
    PhaseEarly phase 1
    Registry statusCompleted

  • A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain

    NCT03240783 · start 2017-07-08

    Registered record
    Registry ID
    NCT03240783
    Conditions
    Acute Sciatica
    Interventions
    Betamethasone OR Dexamethasone Injectable; Normal Saline Flush, 0.9% Injectable Solution; Dexamethasone Oral Tablet; Sham Injection and/or oral placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2017-07-08
    Completion
    2018-10
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Sciatica
    InterventionBetamethasone OR Dexamethasone Injectable; Normal Saline Flush, 0.9% Injectable Solution; Dexamethasone Oral Tablet; Sham Injection and/or oral placebo
    PhasePhase 2
    Registry statusUnknown

  • Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy

    NCT02652884 · start 2016-01

    Registered record
    Registry ID
    NCT02652884
    Conditions
    Transient Hypoparathyroidism
    Interventions
    phosphate and betamethasone acetate, 2 mL.; saline 0.9% NaCl
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-01
    Completion
    2017-12
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTransient Hypoparathyroidism
    Interventionphosphate and betamethasone acetate, 2 mL.; saline 0.9% NaCl
    PhasePhase 4
    Registry statusUnknown

  • Therapeutic Effect of Botulinum Toxin A for the Treatment of Plantar Fasciitis.

    NCT03054610 · start 2015-01

    Registered record
    Registry ID
    NCT03054610
    Conditions
    Plantar Fascitis; Botulinum Toxins, Type A
    Interventions
    Betamethason Sodium Phosphate; Ropivacaine; Botulinum Toxins, Type A
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-01
    Completion
    2020-04
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlantar Fascitis; Botulinum Toxins, Type A
    InterventionBetamethason Sodium Phosphate; Ropivacaine; Botulinum Toxins, Type A
    PhasePhase 1
    Registry statusCompleted

  • Intra-articular Betamethasone and the Hypothalamic-pituitary-adrenal Axis

    NCT01799408 · start 2012-10

    Registered record
    Registry ID
    NCT01799408
    Conditions
    Adrenal Suppression
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-10
    Completion
    2013-02
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdrenal Suppression
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)

    NCT01238536 · start 2011-04

    Registered record
    Registry ID
    NCT01238536
    Conditions
    Spinal Stenosis; Low Back Pain
    Interventions
    Epidural steroid with local anesthetic injection; Epidural local anesthetic injection; Epidural steroid injection; Epidural local anesthetic injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-04
    Completion
    2015-09
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinal Stenosis; Low Back Pain
    InterventionEpidural steroid with local anesthetic injection; Epidural local anesthetic injection; Epidural steroid injection; Epidural local anesthetic injection
    PhasePhase 4
    Registry statusCompleted

  • Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial

    NCT01222247 · start 2010-10

    Registered record
    Registry ID
    NCT01222247
    Conditions
    Pregnancy; Respiratory Distress Syndrome; Pregnancy Outcomes; Preterm Birth
    Interventions
    Betamethasone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-10
    Completion
    2022-08-31
    Enrolment
    2,831

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy; Respiratory Distress Syndrome; Pregnancy Outcomes; Preterm Birth
    InterventionBetamethasone; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Efficacy and Tolerability of Prednisolone Acetate 0.5% Cream Versus Betamethasone Valerate 0.1% Cream in Cortisosensitive Dermatosis

    NCT01011621 · start 2010-02

    Registered record
    Registry ID
    NCT01011621
    Conditions
    Dermatitis, Atopic; Dermatitis, Contact; Dermatitis, Seborrheic; Psoriasis
    Interventions
    0.5% prednisolone acetate cream; 0.1% betamethasone valerate cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2010-02
    Completion
    Not recorded
    Enrolment
    170

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis, Atopic; Dermatitis, Contact; Dermatitis, Seborrheic; Psoriasis
    Intervention0.5% prednisolone acetate cream; 0.1% betamethasone valerate cream
    PhasePhase 3
    Registry statusUnknown

  • Antenatal Corticoid Therapy for Late Preterm Babies

    NCT00675246 · start 2008-05

    Registered record
    Registry ID
    NCT00675246
    Conditions
    Hyaline Membrane Disease; Transient Tachypnea
    Interventions
    Betamethasone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-05
    Completion
    2010-05
    Enrolment
    320

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyaline Membrane Disease; Transient Tachypnea
    InterventionBetamethasone
    PhaseNot applicable
    Registry statusCompleted

  • Prolotherapy Versus Steroids for Thumb Carpo-metacarpal Joint Arthritis

    NCT00685880 · start 2008-05

    Registered record
    Registry ID
    NCT00685880
    Conditions
    Thumb Carpometacarpal Joint Osteoarthritis
    Interventions
    Prolotherapy (10% dextrose solution); Betamethasone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-05
    Completion
    2010-07
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThumb Carpometacarpal Joint Osteoarthritis
    InterventionProlotherapy (10% dextrose solution); Betamethasone
    PhaseNot applicable
    Registry statusTerminated

  • ORTHOVISC Shoulder Osteoarthritis Study

    NCT00436969 · start 2006-12

    Registered record
    Registry ID
    NCT00436969
    Conditions
    Glenohumeral Osteoarthritis
    Interventions
    Orthovisc; Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-12
    Completion
    2011-08
    Enrolment
    274

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlenohumeral Osteoarthritis
    InterventionOrthovisc; Control
    PhasePhase 3
    Registry statusCompleted