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AMR Drug RepurposingSmart Screeningresearch prototype

Betamethasone Acetate

FDA-approved product (injectable, injection).

Registered studies
27
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Betamethasone Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Anemia
  • Asthma
  • Dermatitis
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion
  • Nephrotic syndrome
  • Type III hypersensitivity reaction disease
  • Ulcerative colitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids acting locally; Corticosteroids; Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA55.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli34.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae29.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis26.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

27registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Betamethasone Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Betamethasone Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study)

    NCT07762170 · start 2026-07-30

    Registered record
    Registry ID
    NCT07762170
    Conditions
    Back Pain Lower Back; Neck Pain; Radiculopathy Multiple Sites; Spinal Stenosis Cervicothoracic Region; Spinal Stenosis Lumbar; Failed Back Surgery Syndrome (FBSS); Sciatica; Intervertebral Disc Disorders With Radiculopathy, Lumbar Region; Spine Osteoarthritis
    Interventions
    triamcinolone acetonide (Kenalog); Celestone Soluspan 6Mg/Ml Suspension for Injection; Depo-Medrol 40Mg/Ml Suspension for Injection; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-07-30
    Completion
    2030-03
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBack Pain Lower Back; Neck Pain; Radiculopathy Multiple Sites; Spinal Stenosis Cervicothoracic Region +5 more
    Interventiontriamcinolone acetonide (Kenalog); Celestone Soluspan 6Mg/Ml Suspension for Injection; Depo-Medrol 40Mg/Ml Suspension for Injection; Dexamethasone
    PhasePhase 4
    Registry statusRecruiting

  • The TRIBECA Study (TRIessence/Byqlovi for Easier CAtaract Surgery)

    NCT07276802 · start 2026-04-01

    Registered record
    Registry ID
    NCT07276802
    Conditions
    Post Cataract Surgery
    Interventions
    Triamcinolone (Optional); control group
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-04-01
    Completion
    2027-01-31
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Cataract Surgery
    InterventionTriamcinolone (Optional); control group
    PhasePhase 4
    Registry statusNot yet recruiting

  • Efficacy of Corticosteroid Injection and Nerve Hydrodissection in Carpal Tunnel Syndrome

    NCT06882603 · start 2025-10-14

    Registered record
    Registry ID
    NCT06882603
    Conditions
    Carpal Tunnel Syndrome (CTS)
    Interventions
    hydrodissection; Steroid injection; Exercise
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-10-14
    Completion
    2026-05-05
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarpal Tunnel Syndrome (CTS)
    Interventionhydrodissection; Steroid injection; Exercise
    PhaseNot applicable
    Registry statusRecruiting

  • Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus

    NCT06498180 · start 2024-12-31

    Registered record
    Registry ID
    NCT06498180
    Conditions
    Oral Lichen Planus; Periodontal Diseases
    Interventions
    Periodontal initial treatment under local anesthesia; Glucocorticoid Therapy; oral hygiene instruction
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2024-12-31
    Completion
    2028-03-31
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Lichen Planus; Periodontal Diseases
    InterventionPeriodontal initial treatment under local anesthesia; Glucocorticoid Therapy; oral hygiene instruction
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Corticosteroids in Carpal Tunnel Syndrome. Prospective Randomised Controlled Non-inferiority Study

    NCT06272682 · start 2023-07-17

    Registered record
    Registry ID
    NCT06272682
    Conditions
    Carpal Tunnel Syndrome
    Interventions
    Systemic bethametasone injection; Local bethametasone injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-07-17
    Completion
    2025-10-11
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarpal Tunnel Syndrome
    InterventionSystemic bethametasone injection; Local bethametasone injection
    PhaseNot applicable
    Registry statusUnknown

  • Evaluation of Efficacy and Safety of Topical 1% Medroxyprogesterone in the Corneal Epithelium Healing After PRK

    NCT05973253 · start 2023-04-21

    Registered record
    Registry ID
    NCT05973253
    Conditions
    Photorefractive Keratectomy
    Interventions
    prepared drop of medroxy progestrone acetat 1%
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2023-04-21
    Completion
    2023-07-06
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPhotorefractive Keratectomy
    Interventionprepared drop of medroxy progestrone acetat 1%
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population

    NCT05724446 · start 2022-12-12

    Registered record
    Registry ID
    NCT05724446
    Conditions
    Cataracts Infantile
    Interventions
    Clobetasol Propionate; Prednisolone acetate ophthalmic suspension, 1%
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2022-12-12
    Completion
    2025-12-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCataracts Infantile
    InterventionClobetasol Propionate; Prednisolone acetate ophthalmic suspension, 1%
    PhasePhase 3
    Registry statusRecruiting

  • Opioid-free Total Hip Arthroplasty

    NCT04421196 · start 2022-09-15

    Registered record
    Registry ID
    NCT04421196
    Conditions
    Hip Osteoarthritis
    Interventions
    Exclusion of opioid analgesics
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2022-09-15
    Completion
    2023-12-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Osteoarthritis
    InterventionExclusion of opioid analgesics
    PhaseNot applicable
    Registry statusWithdrawn

  • Betamethasone and Complications of Lower Third Molar Surgery

    NCT07297264 · start 2022-01-03

    Registered record
    Registry ID
    NCT07297264
    Conditions
    Morbidity; Third Molars Extraction; Steroid Injection
    Interventions
    Betamethasone; normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2022-01-03
    Completion
    2023-03-26
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMorbidity; Third Molars Extraction; Steroid Injection
    InterventionBetamethasone; normal saline
    PhasePhase 3
    Registry statusTerminated

  • Low Dose Antenatal Corticosteroids for Late Preterm Delivery

    NCT05698966 · start 2022-01-01

    Registered record
    Registry ID
    NCT05698966
    Conditions
    Respiratory Morbidity; Preterm Labor
    Interventions
    we will use reduced dose of acceptable corticosteroids treatment for preterm birth
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2022-01-01
    Completion
    2028-01-01
    Enrolment
    1,510

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Morbidity; Preterm Labor
    Interventionwe will use reduced dose of acceptable corticosteroids treatment for preterm birth
    PhaseNot applicable
    Registry statusRecruiting

  • Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid Eye Disease

    NCT04976816 · start 2021-12-01

    Registered record
    Registry ID
    NCT04976816
    Conditions
    Thyroid Eye Disease
    Interventions
    peri-levator betamethasone injection; peri-levator triamcinolone injection; peri-levator and retrobulbar betamethasone injection; peri-levator and retrobulbar triamcinolone injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2021-12-01
    Completion
    2023-10-30
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThyroid Eye Disease
    Interventionperi-levator betamethasone injection; peri-levator triamcinolone injection; peri-levator and retrobulbar betamethasone injection; peri-levator and retrobulbar triamcinolone injection
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Amnion-Based Injections in the Shoulder

    NCT03770546 · start 2021-10-30

    Registered record
    Registry ID
    NCT03770546
    Conditions
    Osteoarthritis of the Shoulder; Adhesive Capsulitis
    Interventions
    Amnion Injection; Betamethasone injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2021-10-30
    Completion
    2023-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis of the Shoulder; Adhesive Capsulitis
    InterventionAmnion Injection; Betamethasone injection
    PhaseNot applicable
    Registry statusWithdrawn

  • Effect of ZILRETTA Versus CELESTONE on Quality of Life, Pain, Neuromuscular Function, and Physical Performance

    NCT05058209 · start 2020-11-30

    Registered record
    Registry ID
    NCT05058209
    Conditions
    Osteoarthritis, Knee
    Interventions
    Triamcinolone acetonide extended-release injectable suspension; Betamethasone sodium phosphate and betamethasone acetate Injectable Suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-11-30
    Completion
    2021-04-28
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Knee
    InterventionTriamcinolone acetonide extended-release injectable suspension; Betamethasone sodium phosphate and betamethasone acetate Injectable Suspension
    PhasePhase 4
    Registry statusCompleted

  • Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars)

    NCT04593706 · start 2020-11-01

    Registered record
    Registry ID
    NCT04593706
    Conditions
    Keloid; Hypertrophic Scar; Scars; Scarring
    Interventions
    Betamethasone acetate + Betamethasone sodium phosphate; Dexamethasone sodium phosphate; Methylprednisolone acetate; Triamcinolone acetonide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-11-01
    Completion
    2021-10-31
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeloid; Hypertrophic Scar; Scars; Scarring
    InterventionBetamethasone acetate + Betamethasone sodium phosphate; Dexamethasone sodium phosphate; Methylprednisolone acetate; Triamcinolone acetonide
    PhaseNot applicable
    Registry statusUnknown

  • Effectiveness Study of Ketoconazole and Betamethasone to Treat Fungal Infection and Dermatophytosis

    NCT02582177 · start 2019-06-11

    Registered record
    Registry ID
    NCT02582177
    Conditions
    Tinea
    Interventions
    Candicort®; Nizoral®; Baycuten N®; Canesten®
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2019-06-11
    Completion
    2020-03-24
    Enrolment
    125

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTinea
    InterventionCandicort®; Nizoral®; Baycuten N®; Canesten®
    PhasePhase 3
    Registry statusCompleted