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AMR Drug RepurposingSmart Screeningresearch prototype

Propranolol Hydrochloride

FDA-approved product (tablet, oral), marketed as Hemangeol, Inderal, Inderal La and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Propranolol Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Angina pectoris
  • Cardiac arrhythmia
  • Cardiovascular disease
  • Coronary atherosclerosis
  • Hemangioma
  • Hypertension
  • Migraine disorder
  • Stroke
  • Wolff-Parkinson-White Syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta blocking agents, non-selective
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA15.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli20.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Propranolol Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Propranolol Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study of Continuous Blood Pressure Monitoring in Healthy Participants

    NCT05692869 · start 2023-01-31

    Registered record
    Registry ID
    NCT05692869
    Conditions
    Healthy
    Interventions
    Propranolol; Pseudoephedrine; ABPM and Wearable Novel Devices; No Intervention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-01-31
    Completion
    2023-04-04
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionPropranolol; Pseudoephedrine; ABPM and Wearable Novel Devices; No Intervention
    PhaseNot applicable
    Registry statusCompleted

  • Propranolol and Von Hippel-Lindau Disease

    NCT05424016 · start 2023-01-16

    Registered record
    Registry ID
    NCT05424016
    Conditions
    Hemangioblastoma of CNS; Von Hippel-Lindau Disease
    Interventions
    Propranolol; follow-up
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2023-01-16
    Completion
    2026-11-01
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemangioblastoma of CNS; Von Hippel-Lindau Disease
    InterventionPropranolol; follow-up
    PhaseNot applicable
    Registry statusRecruiting

  • A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline

    NCT05189977 · start 2022-09-07

    Registered record
    Registry ID
    NCT05189977
    Conditions
    Post-traumatic Stress Disorder (PTSD)
    Interventions
    Propranolol; Prazosin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2022-09-07
    Completion
    2023-08-03
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-traumatic Stress Disorder (PTSD)
    InterventionPropranolol; Prazosin
    PhasePhase 1
    Registry statusTerminated

  • Reconsolidation Therapy With Propranolol as a Treatment for Chronic Pain

    NCT05085782 · start 2022-02-07

    Registered record
    Registry ID
    NCT05085782
    Conditions
    Chronic Low-back Pain; Fibromyalgia
    Interventions
    Propranolol Hydrochloride; Placebo; Reactivation procedure; Pain neuroscience education
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2022-02-07
    Completion
    2025-08-31
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Low-back Pain; Fibromyalgia
    InterventionPropranolol Hydrochloride; Placebo; Reactivation procedure; Pain neuroscience education
    PhasePhase 2
    Registry statusCompleted

  • Propranolol for Protracted Labor

    NCT04741698 · start 2021-07-27

    Registered record
    Registry ID
    NCT04741698
    Conditions
    Labour; Obstructed; Labor Dystocia
    Interventions
    Propranolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2021-07-27
    Completion
    2022-07-01
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLabour; Obstructed; Labor Dystocia
    InterventionPropranolol
    PhasePhase 1
    Registry statusCompleted

  • Immune Checkpoint Inhibitors With or Without Propranolol Hydrochloride In Patients With Urothelial Carcinoma

    NCT04848519 · start 2021-05-20

    Registered record
    Registry ID
    NCT04848519
    Conditions
    Locally Advanced Bladder Urothelial Carcinoma; Locally Advanced Renal Pelvis Urothelial Carcinoma; Locally Advanced Ureter Urothelial Carcinoma; Locally Advanced Urethral Urothelial Carcinoma; Locally Advanced Urothelial Carcinoma; Metastatic Bladder Urothelial Carcinoma; Metastatic Renal Pelvis Urothelial Carcinoma; Metastatic Ureter Urothelial Carcinoma; Metastatic Urethral Urothelial Carcinoma; Metastatic Urothelial Carcinoma; Stage IV Bladder Cancer AJCC v8; Stage IV Renal Pelvis Cancer AJCC v8; Stage IV Ureter Cancer AJCC v8; Stage IV Urethral Cancer AJCC v8
    Interventions
    Pembrolizumab; Propranolol Hydrochloride; Nivolumab; Avelumab
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2021-05-20
    Completion
    2026-12-04
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLocally Advanced Bladder Urothelial Carcinoma; Locally Advanced Renal Pelvis Urothelial Carcinoma; Locally Advanced Ureter Urothelial Carcinoma; Locally Advanced Urethral Urothelial Carcinoma +10 more
    InterventionPembrolizumab; Propranolol Hydrochloride; Nivolumab; Avelumab
    PhasePhase 2
    Registry statusActive not recruiting

  • Crossover Study of Propranolol vs Ivabradine in POTS

    NCT04186286 · start 2021-02-01

    Registered record
    Registry ID
    NCT04186286
    Conditions
    Postural Tachycardia Syndrome
    Interventions
    Ivabradine 4-week course; Propranolol 4-week course; Placebo 4-week course
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2021-02-01
    Completion
    2026-12-31
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostural Tachycardia Syndrome
    InterventionIvabradine 4-week course; Propranolol 4-week course; Placebo 4-week course
    PhasePhase 2
    Registry statusRecruiting

  • Comorbidity-Based Propranolol Use in Pediatric Migraine

    NCT07103031 · start 2021-01-01

    Registered record
    Registry ID
    NCT07103031
    Conditions
    Pediatric Migraine; Migraine Disorders, Brain; Vitamin D Deficiency
    Interventions
    Behavioral therapy; Propranolol
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-01-01
    Completion
    2023-12-31
    Enrolment
    488

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPediatric Migraine; Migraine Disorders, Brain; Vitamin D Deficiency
    InterventionBehavioral therapy; Propranolol
    PhaseNot recorded
    Registry statusCompleted

  • Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status

    NCT04508244 · start 2020-12-29

    Registered record
    Registry ID
    NCT04508244
    Conditions
    Trauma; Brain Injuries; Stress Reaction; Beta Blockers; Troponin
    Interventions
    Placebo; Propranolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2020-12-29
    Completion
    2024-12-31
    Enrolment
    771

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTrauma; Brain Injuries; Stress Reaction; Beta Blockers +1 more
    InterventionPlacebo; Propranolol
    PhasePhase 4
    Registry statusUnknown

  • A Study of Ponesimod in Healthy Adult Participants Receiving Propranolol at Steady State

    NCT03882255 · start 2019-03-20

    Registered record
    Registry ID
    NCT03882255
    Conditions
    Healthy
    Interventions
    Ponesimod dose range (2 - 20 mg); Placebo Propranolol; Propranolol 80 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-03-20
    Completion
    2019-08-26
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionPonesimod dose range (2 - 20 mg); Placebo Propranolol; Propranolol 80 mg
    PhasePhase 1
    Registry statusCompleted

  • Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?

    NCT03588754 · start 2018-09-15

    Registered record
    Registry ID
    NCT03588754
    Conditions
    Alcohol Drinking
    Interventions
    Propranolol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Suspended
    Start
    2018-09-15
    Completion
    2027-08-31
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcohol Drinking
    InterventionPropranolol; Placebo
    PhasePhase 2
    Registry statusSuspended

  • Propranolol Hydrochloride and Pembrolizumab in Treating Patients With Stage IIIC-IV Melanoma That Cannot Be Removed by Surgery

    NCT03384836 · start 2018-01-31

    Registered record
    Registry ID
    NCT03384836
    Conditions
    Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7
    Interventions
    Laboratory Biomarker Analysis; Pembrolizumab; Propranolol Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Suspended
    Start
    2018-01-31
    Completion
    2027-05-31
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7
    InterventionLaboratory Biomarker Analysis; Pembrolizumab; Propranolol Hydrochloride
    PhasePhase 1 / Phase 2
    Registry statusSuspended

  • A Study of Lasmiditan and Propranolol in Healthy Participants

    NCT03270644 · start 2017-08-31

    Registered record
    Registry ID
    NCT03270644
    Conditions
    Healthy
    Interventions
    Lasmiditan; Propranolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2017-08-31
    Completion
    2017-11-22
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionLasmiditan; Propranolol
    PhasePhase 1
    Registry statusCompleted

  • Adrenergic System in Islet Transplantation

    NCT03079921 · start 2017-01-20

    Registered record
    Registry ID
    NCT03079921
    Conditions
    Type1diabetes; Hypoglycemia; Hypoglycemia Unawareness; Islet Cell Transplantation
    Interventions
    Phentolamine; Propranolol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2017-01-20
    Completion
    2025-12-31
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType1diabetes; Hypoglycemia; Hypoglycemia Unawareness; Islet Cell Transplantation
    InterventionPhentolamine; Propranolol; Placebo
    PhaseEarly phase 1
    Registry statusCompleted

  • Disruption of Memory Reconsolidating as a Treatment for Panic Disorder

    NCT02631694 · start 2016-04

    Registered record
    Registry ID
    NCT02631694
    Conditions
    Panic Disorder
    Interventions
    Propranolol; Placebo; Carbon dioxide; Compressed air
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2016-04
    Completion
    2019-09
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPanic Disorder
    InterventionPropranolol; Placebo; Carbon dioxide; Compressed air
    PhasePhase 2
    Registry statusUnknown