Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Propranolol Hydrochloride

FDA-approved product (tablet, oral), marketed as Hemangeol, Inderal, Inderal La and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Propranolol Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Angina pectoris
  • Cardiac arrhythmia
  • Cardiovascular disease
  • Coronary atherosclerosis
  • Hemangioma
  • Hypertension
  • Migraine disorder
  • Stroke
  • Wolff-Parkinson-White Syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta blocking agents, non-selective
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA15.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli20.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Propranolol Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Propranolol Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Impact of Propranolol on the Prognosis of Patients With Decompensated Cirrhosis and MELD Score > 9

    NCT07652203 · start 2026-09

    Registered record
    Registry ID
    NCT07652203
    Conditions
    Cirrhosis
    Interventions
    conventional therapy; propranolol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-09
    Completion
    2028-07
    Enrolment
    466

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCirrhosis
    Interventionconventional therapy; propranolol
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Chinese Real-world Study of Treatment of Vestibular Migraine

    NCT07203248 · start 2025-12

    Registered record
    Registry ID
    NCT07203248
    Conditions
    Vestibular Migraine; Dizziness; Vertigo
    Interventions
    CGRP R Inhibitor; CGRP Inhibitor; none-CGRP
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2025-12
    Completion
    2028-12
    Enrolment
    2,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVestibular Migraine; Dizziness; Vertigo
    InterventionCGRP R Inhibitor; CGRP Inhibitor; none-CGRP
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Analysis of Clinical Outcomes in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Tremor

    NCT07212244 · start 2025-10

    Registered record
    Registry ID
    NCT07212244
    Conditions
    Essential Tremor; Essential Tremor, Movement Disorders
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2025-10
    Completion
    2032-09
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Tremor; Essential Tremor, Movement Disorders
    InterventionNot recorded
    PhaseNot recorded
    Registry statusRecruiting

  • Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI

    NCT06870370 · start 2025-09-20

    Registered record
    Registry ID
    NCT06870370
    Conditions
    Traumatic Brain Injury (TBI) Patients; Intracranial Pressure; Intensive Care Unit; Mortality
    Interventions
    propranolol; normal saline IV
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2025-09-20
    Completion
    2025-09-20
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTraumatic Brain Injury (TBI) Patients; Intracranial Pressure; Intensive Care Unit; Mortality
    Interventionpropranolol; normal saline IV
    PhasePhase 3
    Registry statusNot yet recruiting

  • A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial

    NCT07074756 · start 2025-09-12

    Registered record
    Registry ID
    NCT07074756
    Conditions
    Glioma; Recurrent Glioma; Recurrent Glioblastoma
    Interventions
    Chemotherapy; Computed Tomography; Internet-Based Intervention; Magnetic Resonance Imaging; Neurologic Examination; Questionnaire Administration; Surveillance; Propranolol; Imipramine; Bevacizumab
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-09-12
    Completion
    2028-08-31
    Enrolment
    202

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlioma; Recurrent Glioma; Recurrent Glioblastoma
    InterventionChemotherapy; Computed Tomography; Internet-Based Intervention; Magnetic Resonance Imaging +6 more
    PhaseNot applicable
    Registry statusRecruiting

  • Comparative Efficacy of Flunarizine and Propanolol in Pediatric Migraine

    NCT07354126 · start 2025-09-01

    Registered record
    Registry ID
    NCT07354126
    Conditions
    Migraine
    Interventions
    Flunarizine; Propranolol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-09-01
    Completion
    2026-02-28
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionFlunarizine; Propranolol
    PhaseNot applicable
    Registry statusRecruiting

  • Oral Propranolol Versus Fractional Carbon Dioxide CO2 Laser Assisted Delivery of Topical Timolol for Treatment of Infantile Hemangioma

    NCT07560332 · start 2025-01-01

    Registered record
    Registry ID
    NCT07560332
    Conditions
    Infantile Hemangioma (IH)
    Interventions
    Propranolol 1; Fractional CO2 laser with topical timolol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-01-01
    Completion
    2026-01-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfantile Hemangioma (IH)
    InterventionPropranolol 1; Fractional CO2 laser with topical timolol
    PhaseNot applicable
    Registry statusCompleted

  • Frequency of Hypoglycemia in Children With Beta-blocker Treated Long QT-syndrome

    NCT07233421 · start 2024-12-09

    Registered record
    Registry ID
    NCT07233421
    Conditions
    Long QT Syndrome; Hypoglycemia
    Interventions
    Continuous Glucose Monitoring
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Enrolling by invitation
    Start
    2024-12-09
    Completion
    2027-12-31
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLong QT Syndrome; Hypoglycemia
    InterventionContinuous Glucose Monitoring
    PhaseNot applicable
    Registry statusEnrolling by invitation

  • Beta-Adrenergic Modulation of Drug Cue Reactivity

    NCT05587361 · start 2024-11-26

    Registered record
    Registry ID
    NCT05587361
    Conditions
    Tobacco Use Disorder; Nicotine Dependence; Cigarette Smoking
    Interventions
    Propranolol; Nicotine Patch; Placebo Propranolol; Placebo Patch
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2024-11-26
    Completion
    2027-03-31
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTobacco Use Disorder; Nicotine Dependence; Cigarette Smoking
    InterventionPropranolol; Nicotine Patch; Placebo Propranolol; Placebo Patch
    PhasePhase 4
    Registry statusRecruiting

  • Propranolol and Pembrolizumab for Tumor Re-sensitization and Treatment of Patients With Checkpoint Inhibitor Refractory Metastatic or Unresectable Triple Negative Breast Cancer

    NCT05741164 · start 2024-09-01

    Registered record
    Registry ID
    NCT05741164
    Conditions
    Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Triple-Negative Breast Carcinoma; Refractory Triple-Negative Breast Carcinoma; Unresectable Triple-Negative Breast Carcinoma
    Interventions
    Biopsy; Biospecimen Collection; Computed Tomography; Pembrolizumab; Propranolol; Questionnaire Administration
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2024-09-01
    Completion
    2029-06-30
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Triple-Negative Breast Carcinoma; Refractory Triple-Negative Breast Carcinoma +1 more
    InterventionBiopsy; Biospecimen Collection; Computed Tomography; Pembrolizumab +2 more
    PhasePhase 2
    Registry statusRecruiting

  • A Study Comparing Propranolol and Amantadine for Reducing Tremors in People With Parkinson's Disease

    NCT07113015 · start 2024-07-05

    Registered record
    Registry ID
    NCT07113015
    Conditions
    Parkinson Disease (PD); Tremor
    Interventions
    propranolol; Amantadine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-07-05
    Completion
    2024-12-02
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParkinson Disease (PD); Tremor
    Interventionpropranolol; Amantadine
    PhaseNot applicable
    Registry statusCompleted

  • Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

    NCT06417177 · start 2024-06-03

    Registered record
    Registry ID
    NCT06417177
    Conditions
    Aging; Menopause; Hypoxia; Vasodilation
    Interventions
    Placebo; Propranolol; Gemtesa
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Recruiting
    Start
    2024-06-03
    Completion
    2026-12
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAging; Menopause; Hypoxia; Vasodilation
    InterventionPlacebo; Propranolol; Gemtesa
    PhaseEarly phase 1
    Registry statusRecruiting

  • Propranolol for the Treatment of Traumatic Brain Injury

    NCT06262061 · start 2024-03

    Registered record
    Registry ID
    NCT06262061
    Conditions
    TBI (Traumatic Brain Injury)
    Interventions
    Propranolol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2024-03
    Completion
    2025-09
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTBI (Traumatic Brain Injury)
    InterventionPropranolol; Placebo
    PhaseEarly phase 1
    Registry statusUnknown

  • Ph2, Study to Assess the Safety and Efficacy of GPC 100 and Propranolol With and Without G-CSF for the Mobilization of Stem Cells in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

    NCT05561751 · start 2023-02-13

    Registered record
    Registry ID
    NCT05561751
    Conditions
    Multiple Myeloma
    Interventions
    GPC-100; Propranolol; G-CSF
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2023-02-13
    Completion
    2025-10-31
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Myeloma
    InterventionGPC-100; Propranolol; G-CSF
    PhasePhase 2
    Registry statusCompleted

  • Treatment of Pediatric Post-traumatic Stress Disorder With Memory Reactivation Under the Influence of Propranolol

    NCT04985344 · start 2023-02-01

    Registered record
    Registry ID
    NCT04985344
    Conditions
    PTSD
    Interventions
    Propranolol Oral Product; Placebo; memory reactivation
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2023-02-01
    Completion
    2027-09
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPTSD
    InterventionPropranolol Oral Product; Placebo; memory reactivation
    PhasePhase 3
    Registry statusRecruiting