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AMR Drug RepurposingSmart Screeningresearch prototype

Propranolol Hydrochloride

FDA-approved product (tablet, oral), marketed as Hemangeol, Inderal, Inderal La and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Propranolol Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Angina pectoris
  • Cardiac arrhythmia
  • Cardiovascular disease
  • Coronary atherosclerosis
  • Hemangioma
  • Hypertension
  • Migraine disorder
  • Stroke
  • Wolff-Parkinson-White Syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta blocking agents, non-selective
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA15.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli20.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Propranolol Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Propranolol Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Biopsychosocial Influence on Shoulder Pain

    NCT02620579 · start 2016-01

    Registered record
    Registry ID
    NCT02620579
    Conditions
    Shoulder Pain
    Interventions
    Propranolol LA (60 mg); Placebo; Shoulder Anatomy Education; Pain Processing Education
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-01
    Completion
    2021-11-05
    Enrolment
    264

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShoulder Pain
    InterventionPropranolol LA (60 mg); Placebo; Shoulder Anatomy Education; Pain Processing Education
    PhasePhase 2
    Registry statusCompleted

  • Genetic Predictors of Analgesic Efficacy of Propranolol for Treating Postoperative Pain

    NCT02511483 · start 2015-05-18

    Registered record
    Registry ID
    NCT02511483
    Conditions
    Postoperative Pain
    Interventions
    Propranolol PO; IV-PCA morphine; Placebo PO; Quantitative Sensory Testing (QST); Psychometric assessment; COMT-haplotypes
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2015-05-18
    Completion
    2016-11-12
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionPropranolol PO; IV-PCA morphine; Placebo PO; Quantitative Sensory Testing (QST) +2 more
    PhasePhase 2
    Registry statusTerminated

  • Role of Propranolol as Compared to Bleomycin in Management of Hemangioma

    NCT05327309 · start 2015-05-08

    Registered record
    Registry ID
    NCT05327309
    Conditions
    Hemangioma; Propranolol
    Interventions
    Bleomycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-05-08
    Completion
    2018-01-01
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemangioma; Propranolol
    InterventionBleomycin
    PhaseNot applicable
    Registry statusCompleted

  • Modafinil and Cognitive Function in POTS

    NCT01988883 · start 2014-10

    Registered record
    Registry ID
    NCT01988883
    Conditions
    Postural Tachycardia Syndrome
    Interventions
    Placebo; Modafinil; Propranolol
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Active not recruiting
    Start
    2014-10
    Completion
    2026-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostural Tachycardia Syndrome
    InterventionPlacebo; Modafinil; Propranolol
    PhaseEarly phase 1
    Registry statusActive not recruiting

  • Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

    NCT01950520 · start 2014-02-07

    Registered record
    Registry ID
    NCT01950520
    Conditions
    Healthy Volunteers
    Interventions
    Propranolol; Pindolol; Dantrolene; Magnesium Sulfate; Caffeine; Qsymia; Topiramate; Phentermine; Naltrexone; Mirabegron 50mg; Mirabegron 200mg; Placebo Cohort 1; Placebo Cohort 2; Placebo for Mirabegron
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-02-07
    Completion
    2024-06-11
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionPropranolol; Pindolol; Dantrolene; Magnesium Sulfate +10 more
    PhasePhase 2
    Registry statusCompleted

  • Safety and Efficacy of Propranolol Eye Drops in Treating Retinopathy of Premature

    NCT02014454 · start 2013-11

    Registered record
    Registry ID
    NCT02014454
    Conditions
    Retinopathy of Prematurity
    Interventions
    Propranolol eye drops
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-11
    Completion
    2014-08
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRetinopathy of Prematurity
    InterventionPropranolol eye drops
    PhasePhase 2
    Registry statusCompleted

  • Noradrenergic Manipulation and Virtual Reality Exposure Therapy in Phobic Participants

    NCT02007694 · start 2013-03

    Registered record
    Registry ID
    NCT02007694
    Conditions
    Phobic Disorders
    Interventions
    Virtual Reality Exposure Therapy (VRET)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2013-03
    Completion
    2014-12
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPhobic Disorders
    InterventionVirtual Reality Exposure Therapy (VRET)
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Memory Reconsolidation Blockade for Treating Drug Addiction

    NCT01634347 · start 2012-01

    Registered record
    Registry ID
    NCT01634347
    Conditions
    Substance Dependence
    Interventions
    Propranolol and memory reactivation; Placebo and memory reactivation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-01
    Completion
    2014-05
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubstance Dependence
    InterventionPropranolol and memory reactivation; Placebo and memory reactivation
    PhasePhase 2
    Registry statusCompleted

  • Reducing Drug Craving Memories

    NCT01319214 · start 2011-03

    Registered record
    Registry ID
    NCT01319214
    Conditions
    Cocaine Addiction
    Interventions
    Inderal
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2011-03
    Completion
    2015-03
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine Addiction
    InterventionInderal
    PhaseNot applicable
    Registry statusUnknown

  • Therapeutic Targeting of Stress Factors in Ovarian Cancer Patients

    NCT01308944 · start 2010-08

    Registered record
    Registry ID
    NCT01308944
    Conditions
    Invasive Epithelial Ovarian Cancer; Primary Peritoneal Carcinoma; Fallopian Tube Cancer
    Interventions
    Propranolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-08
    Completion
    2015-08
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Epithelial Ovarian Cancer; Primary Peritoneal Carcinoma; Fallopian Tube Cancer
    InterventionPropranolol
    PhasePhase 1
    Registry statusCompleted

  • Beta Blockers for the Treatment of Asthma

    NCT01074853 · start 2010-05

    Registered record
    Registry ID
    NCT01074853
    Conditions
    Asthma
    Interventions
    propranolol; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-05
    Completion
    2012-03
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    Interventionpropranolol; placebo
    PhasePhase 2
    Registry statusCompleted

  • Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study

    NCT01238471 · start 2010-05

    Registered record
    Registry ID
    NCT01238471
    Conditions
    Retinopathy of Prematurity
    Interventions
    propranolol; sucrose 5%
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2010-05
    Completion
    2012-07
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRetinopathy of Prematurity
    Interventionpropranolol; sucrose 5%
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol (S-HCC)

    NCT01451658 · start 2009-12

    Registered record
    Registry ID
    NCT01451658
    Conditions
    Gastroesophageal Varices Hemorrhage; Hepatocellular Carcinoma
    Interventions
    propranolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2009-12
    Completion
    2020-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastroesophageal Varices Hemorrhage; Hepatocellular Carcinoma
    Interventionpropranolol
    PhasePhase 4
    Registry statusUnknown

  • Low Doses of Cholestyramine in the Treatment of Hyperthyroidism

    NCT00677469 · start 2007-07

    Registered record
    Registry ID
    NCT00677469
    Conditions
    Graves Disease
    Interventions
    Cholestyramine; Cholestyramine; Placebo powder
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-07
    Completion
    2008-01
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGraves Disease
    InterventionCholestyramine; Cholestyramine; Placebo powder
    PhaseNot applicable
    Registry statusCompleted

  • Propranolol in Post Traumatic Stress Disorder

    NCT00465608 · start 2007-04

    Registered record
    Registry ID
    NCT00465608
    Conditions
    Post-Traumatic Stress Disorder
    Interventions
    propranolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-04
    Completion
    2008-11
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-Traumatic Stress Disorder
    Interventionpropranolol
    PhasePhase 2
    Registry statusCompleted