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AMR Drug RepurposingSmart Screeningresearch prototype

Propranolol Hydrochloride

FDA-approved product (tablet, oral), marketed as Hemangeol, Inderal, Inderal La and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Propranolol Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Angina pectoris
  • Cardiac arrhythmia
  • Cardiovascular disease
  • Coronary atherosclerosis
  • Hemangioma
  • Hypertension
  • Migraine disorder
  • Stroke
  • Wolff-Parkinson-White Syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta blocking agents, non-selective
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA15.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli20.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Propranolol Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Propranolol Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • In Vivo Specificity of KUC 7483 CL Co-administered With Bisoprolol, Propranolol, and Acipimox in Healthy Male Subjects

    NCT02256722 · start 2005-10

    Registered record
    Registry ID
    NCT02256722
    Conditions
    Healthy
    Interventions
    KUC 7483 CL; Bisoprolol; Propranolol; Acipimox; Salmeterol
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2005-10
    Completion
    Not recorded
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionKUC 7483 CL; Bisoprolol; Propranolol; Acipimox +1 more
    PhasePhase 1
    Registry statusCompleted

  • Analysis of Atropine and Propranolol Induced Changes

    NCT00251602 · start 2003-03

    Registered record
    Registry ID
    NCT00251602
    Conditions
    Healthy
    Interventions
    Atropine; Propranolol; Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2003-03
    Completion
    2012-08
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionAtropine; Propranolol; Normal Saline
    PhasePhase 1
    Registry statusCompleted

  • Assessment of Mechanisms of Improved Wound Healing

    NCT00673309 · start 2000-07

    Registered record
    Registry ID
    NCT00673309
    Conditions
    Burns
    Interventions
    Stable Isotope Infusion study; Insulin High Dose; oxandrolone; Propranolol; Growth Hormone; Insulin Low Dose; IGF-1/IGFBP-3; Itraconazole; Growth Hormone and Propranolol; Oxandrolone and Propranolol; Placebo or Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2000-07
    Completion
    2013-04
    Enrolment
    644

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurns
    InterventionStable Isotope Infusion study; Insulin High Dose; oxandrolone; Propranolol +7 more
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2

    NCT00158132 · start 1999-09

    Registered record
    Registry ID
    NCT00158132
    Conditions
    Cocaine-Related Disorders
    Interventions
    Propranolol; Amantadine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1999-09
    Completion
    2006-02
    Enrolment
    199

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine-Related Disorders
    InterventionPropranolol; Amantadine; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Beta-Blocker Heart Attack Trial (BHAT)

    NCT00000492 · start 1977-09

    Registered record
    Registry ID
    NCT00000492
    Conditions
    Arrhythmia; Cardiovascular Diseases; Coronary Disease; Death, Sudden, Cardiac; Heart Diseases; Myocardial Infarction; Myocardial Ischemia; Ventricular Fibrillation
    Interventions
    propranolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1977-09
    Completion
    1981-10
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArrhythmia; Cardiovascular Diseases; Coronary Disease; Death, Sudden, Cardiac +4 more
    Interventionpropranolol
    PhasePhase 3
    Registry statusCompleted