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AMR Drug RepurposingSmart Screeningresearch prototype

Doripenem

FDA-approved product (injectable, intravenous), marketed as Doribax.

Registered studies
31
Lab records
52
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Doripenem
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Pyelonephritis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Carbapenems
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DH04

Repurposing investigation

Doripenem is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA98.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli98.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae>99% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis61.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

31registered studies name this medicine, for any condition. See them below.

Experimental

  • K. pneumoniae: measured active in 52 of 52 lab records
Open Doripenem in ChEMBL Registered studies below
Show the 52 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Doripenem with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Pharmacokinetic and Pharmacodynamic Evaluation of Doripenem in Critically Ill Trauma Patients

    NCT01027897 · start 2010-04

    Registered record
    Registry ID
    NCT01027897
    Conditions
    Sepsis
    Interventions
    Doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-04
    Completion
    2011-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis
    InterventionDoripenem
    PhasePhase 4
    Registry statusCompleted

  • Multiple-dose Pharmacokinetics of Doripenem During Continuous Venovenous Hemodiafiltration and Molecular Adsorbent Recirculating System in ICU Patients and During Hemodialysis in Longterm Hemodialysis Patients.

    NCT02018939 · start 2010-03

    Registered record
    Registry ID
    NCT02018939
    Conditions
    Infections During Organ Replacement Therapy
    Interventions
    Pharmacokinetic profiling
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-03
    Completion
    2014-02
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections During Organ Replacement Therapy
    InterventionPharmacokinetic profiling
    PhasePhase 3
    Registry statusCompleted

  • A Study of the Safety and Effectiveness of Doripenem in Filipino Patients With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Complicated Urinary Tract Infections

    NCT01763008 · start 2009-11

    Registered record
    Registry ID
    NCT01763008
    Conditions
    Pneumonia, Bacterial; Nosocomial Infection; Intraabdominal Infections; Urinary Tract Infection
    Interventions
    No intervention
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-11
    Completion
    2012-11
    Enrolment
    170

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Bacterial; Nosocomial Infection; Intraabdominal Infections; Urinary Tract Infection
    InterventionNo intervention
    PhaseNot recorded
    Registry statusCompleted

  • A Study of Doripenem in Infants Less Than 12 Weeks of Age

    NCT01381848 · start 2009-10

    Registered record
    Registry ID
    NCT01381848
    Conditions
    Bacterial Infections
    Interventions
    Doripenem; Doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-10
    Completion
    2012-04
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections
    InterventionDoripenem; Doripenem
    PhasePhase 1
    Registry statusCompleted

  • PROUD Study: A Prospective Study on the Usage Patterns of Doripenem in the Asia Pacific Region

    NCT00986102 · start 2009-07-17

    Registered record
    Registry ID
    NCT00986102
    Conditions
    Pneumonia; Pneumonia, Ventilator-Associated; Urinary Tract Infections
    Interventions
    doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07-17
    Completion
    2011-09-09
    Enrolment
    216

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia; Pneumonia, Ventilator-Associated; Urinary Tract Infections
    Interventiondoripenem
    PhasePhase 4
    Registry statusCompleted

  • Doripenem Intrapulmonary Pharmacokinetics in Healthy Adult Subjects

    NCT00925392 · start 2009-06

    Registered record
    Registry ID
    NCT00925392
    Conditions
    Healthy
    Interventions
    Doripenem; Doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-06
    Completion
    2010-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionDoripenem; Doripenem
    PhasePhase 1
    Registry statusCompleted

  • A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections

    NCT00965848 · start 2009-06

    Registered record
    Registry ID
    NCT00965848
    Conditions
    Infection; Cross Infection; Bacterial Infections; Pneumonia, Ventilator-Associated; Intra-abdominal Infections; Urinary Tract Infections
    Interventions
    Doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-06
    Completion
    2010-07
    Enrolment
    270

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection; Cross Infection; Bacterial Infections; Pneumonia, Ventilator-Associated +2 more
    InterventionDoripenem
    PhasePhase 4
    Registry statusCompleted

  • To Compare Safety and Efficacy of Doripenem Versus Imipenem-Cilastatin in Patients With Ventilator-Associated Pneumonia

    NCT00589693 · start 2008-04

    Registered record
    Registry ID
    NCT00589693
    Conditions
    Ventilator-Associated Pneumonia
    Interventions
    Doripenem; Imipenem-Cilastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2008-04
    Completion
    2011-06
    Enrolment
    274

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentilator-Associated Pneumonia
    InterventionDoripenem; Imipenem-Cilastatin; Placebo
    PhasePhase 3
    Registry statusTerminated

  • A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia

    NCT00515034 · start 2007-10

    Registered record
    Registry ID
    NCT00515034
    Conditions
    Pneumonia, Ventilator-Associated; Pneumonia, Bacterial; Pneumonia; Abdominal Abscess; Bacterial Infections
    Interventions
    Imipenem/cilastatin; Imipenem/cilastatin; Doripenem; Doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-10
    Completion
    2008-11
    Enrolment
    146

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Ventilator-Associated; Pneumonia, Bacterial; Pneumonia; Abdominal Abscess +1 more
    InterventionImipenem/cilastatin; Imipenem/cilastatin; Doripenem; Doripenem
    PhasePhase 2
    Registry statusCompleted

  • An Effectiveness, Safety, and Microbiology Study of Doripenem in Patients With Nosocomial (Hospital-acquired) Pneumonia

    NCT00502801 · start 2007-08

    Registered record
    Registry ID
    NCT00502801
    Conditions
    Pneumonia; Bacterial Pneumonia; Ventilator-Associated Pneumonia; Infections, Nosocomial
    Interventions
    doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-08
    Completion
    2008-11
    Enrolment
    185

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia; Bacterial Pneumonia; Ventilator-Associated Pneumonia; Infections, Nosocomial
    Interventiondoripenem
    PhasePhase 2
    Registry statusCompleted

  • Doripenem in the Treatment of Ventilator-Associated Pneumonia

    NCT00211016 · start 2004-08

    Registered record
    Registry ID
    NCT00211016
    Conditions
    Pneumonia; Ventilators, Mechanical
    Interventions
    doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-08
    Completion
    2006-10
    Enrolment
    318

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia; Ventilators, Mechanical
    Interventiondoripenem
    PhasePhase 3
    Registry statusCompleted

  • Doripenem in the Treatment of Hospital-Acquired Pneumonia

    NCT00211003 · start 2004-05

    Registered record
    Registry ID
    NCT00211003
    Conditions
    Pneumonia
    Interventions
    doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-05
    Completion
    2006-10
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    Interventiondoripenem
    PhasePhase 3
    Registry statusCompleted

  • Doripenem in the Treatment of Complicated Intra-Abdominal Infections

    NCT00210938 · start 2004-03

    Registered record
    Registry ID
    NCT00210938
    Conditions
    Bacterial Infections and Mycoses; Appendicitis; Cholecystitis; Pancreatitis; Peritonitis
    Interventions
    Doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-03
    Completion
    2006-01
    Enrolment
    478

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections and Mycoses; Appendicitis; Cholecystitis; Pancreatitis +1 more
    InterventionDoripenem
    PhasePhase 3
    Registry statusCompleted

  • Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis

    NCT00210990 · start 2004-03

    Registered record
    Registry ID
    NCT00210990
    Conditions
    Urinary Tract Infections; Pyelonephritis
    Interventions
    doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-03
    Completion
    2006-04
    Enrolment
    403

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections; Pyelonephritis
    Interventiondoripenem
    PhasePhase 3
    Registry statusCompleted

  • Doripenem in the Treatment of Complicated Intra-Abdominal Infections

    NCT00229060 · start 2004-03

    Registered record
    Registry ID
    NCT00229060
    Conditions
    Bacterial Infections and Mycoses; Appendicitis; Cholecystitis; Pancreatitis; Peritonitis
    Interventions
    doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-03
    Completion
    2006-03
    Enrolment
    483

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections and Mycoses; Appendicitis; Cholecystitis; Pancreatitis +1 more
    Interventiondoripenem
    PhasePhase 3
    Registry statusCompleted