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AMR Drug RepurposingSmart Screeningresearch prototype

Ampicillin Sodium

FDA-approved product (injectable, injection), marketed as Ampicillin Sodium, Omnipen-N, Penbritin-S and 13 more.

Registered studies
50+
Lab records
69
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Ampicillin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Bacterial meningitis
  • Endocarditis
  • Eye infection
  • Gonorrhea
  • Infection
  • Infectious meningitis
  • Sepsis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Penicillins with extended spectrum; Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CA01; WHO ATC J01CA51; WHO ATC S01AA19

Repurposing investigation

Ampicillin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA26.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli29.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae7.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis32.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 5 of 20 lab records
  • E. coli: measured active in 4 of 10 lab records
  • K. pneumoniae: measured active in 12 of 39 lab records
Open Ampicillin Sodium in ChEMBL Registered studies below
Show the 69 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ampicillin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Meropenem Plus Amoxycillin/CA and Faropenem Plus Amoxycillin/CA in Adult Patients With Newly Diagnosed Pulmonary Tuberculosis

    NCT02349841 · start 2014-09

    Registered record
    Registry ID
    NCT02349841
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Meropenem; Faropenem; Amoxycillin/clavulanic acid; Rifafour e275
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-09
    Completion
    2014-12
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionMeropenem; Faropenem; Amoxycillin/clavulanic acid; Rifafour e275
    PhasePhase 2
    Registry statusCompleted

  • Study of Levofloxacin-based Concomitant Therapy for H. Pylori Eradication in Diabetic Patients

    NCT02466919 · start 2014-05

    Registered record
    Registry ID
    NCT02466919
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Pantoprazole; Amoxicillin; Metronidazole; Levofloxacin; Clarithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-05
    Completion
    2016-09
    Enrolment
    114

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionPantoprazole; Amoxicillin; Metronidazole; Levofloxacin +1 more
    PhasePhase 4
    Registry statusCompleted

  • A Randomized, Open-label Study on Helicobacter Pylori Eradication With Standard Triple Regimen Plus Acetazolamide

    NCT02090738 · start 2014-03

    Registered record
    Registry ID
    NCT02090738
    Conditions
    H. Pylori Infection
    Interventions
    Acetazolamide group; Standard regimen group
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2014-03
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionH. Pylori Infection
    InterventionAcetazolamide group; Standard regimen group
    PhasePhase 2
    Registry statusWithdrawn

  • Phase I Study of Safety and Immunogenicity of ADU-623

    NCT01967758 · start 2014-01-08

    Registered record
    Registry ID
    NCT01967758
    Conditions
    Astrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    Interventions
    Cohort 1; Cohort 2; Cohort 3; Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-01-08
    Completion
    2018-08-15
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAstrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    InterventionCohort 1; Cohort 2; Cohort 3; Antibiotics
    PhasePhase 1
    Registry statusCompleted

  • Piperacillin/Tazobactam for Empirical Therapy of Febrile Neutropenia

    NCT01714570 · start 2012-11

    Registered record
    Registry ID
    NCT01714570
    Conditions
    Febrile; Neutropenia; Hematopoietic Stem Cell Transplantation
    Interventions
    Piperacillin-tazobactam combination product; Imipenem
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-11
    Completion
    2014-04
    Enrolment
    123

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFebrile; Neutropenia; Hematopoietic Stem Cell Transplantation
    InterventionPiperacillin-tazobactam combination product; Imipenem
    PhaseNot applicable
    Registry statusCompleted

  • Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis

    NCT00716183 · start 2008-07

    Registered record
    Registry ID
    NCT00716183
    Conditions
    Mastitis
    Interventions
    Lactobacillus salivarius HN6; Lactobacillus reuteri CR20; Lactobacillus fermentum LC40; Beta-lactam antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2009-05
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMastitis
    InterventionLactobacillus salivarius HN6; Lactobacillus reuteri CR20; Lactobacillus fermentum LC40; Beta-lactam antibiotic
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures

    NCT01524081 · start 2008-07

    Registered record
    Registry ID
    NCT01524081
    Conditions
    Acute Appendicitis; Perforated Gastroduodenal Ulcer; Small Bowel Obstruction
    Interventions
    Metronidazole, Cefuroxime; Amoxicillin (+ clavulanic acid) and Fluconazole; Placebo; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2011-11
    Enrolment
    187

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Appendicitis; Perforated Gastroduodenal Ulcer; Small Bowel Obstruction
    InterventionMetronidazole, Cefuroxime; Amoxicillin (+ clavulanic acid) and Fluconazole; Placebo; Placebo
    PhasePhase 3
    Registry statusCompleted

  • The Role of Antibiotic Treatment in Patients With Acute Mild Cholecystitis - A Prospective Randomized Controlled Trial

    NCT00557453 · start 2008-04

    Registered record
    Registry ID
    NCT00557453
    Conditions
    Acute Cholecystitits
    Interventions
    Antibiotic treatment; No antibiotics
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-04
    Completion
    2010-04
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Cholecystitits
    InterventionAntibiotic treatment; No antibiotics
    PhaseNot recorded
    Registry statusCompleted

  • Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)

    NCT01406275 · start 2008-01

    Registered record
    Registry ID
    NCT01406275
    Conditions
    Otitis Maedia
    Interventions
    Amoxicillin and clavulanate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-01
    Completion
    2008-12
    Enrolment
    363

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOtitis Maedia
    InterventionAmoxicillin and clavulanate
    PhaseNot recorded
    Registry statusCompleted

  • Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections

    NCT00084201 · start 2006-07

    Registered record
    Registry ID
    NCT00084201
    Conditions
    Urinary Tract Infections
    Interventions
    Cranberry juice; Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-07
    Completion
    2007-06
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionCranberry juice; Amoxicillin
    PhaseNot applicable
    Registry statusCompleted

  • Systemic Steroids Plus Antibiotics in Sleep Apnea Syndrome in Children

    NCT00456339 · start 2006-07

    Registered record
    Registry ID
    NCT00456339
    Conditions
    Obstructive Sleep Apnea Syndrome
    Interventions
    Prednisolone and amoxicillin/clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2006-07
    Completion
    2007-07
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObstructive Sleep Apnea Syndrome
    InterventionPrednisolone and amoxicillin/clavulanate
    PhasePhase 4
    Registry statusTerminated

  • Zmax Compared to Augmentin in Sinusitis

    NCT00367120 · start 2006-06

    Registered record
    Registry ID
    NCT00367120
    Conditions
    Sinusitis
    Interventions
    Azithromycin Extended Release; Amoxicillin/Clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-06
    Completion
    2007-02
    Enrolment
    762

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionAzithromycin Extended Release; Amoxicillin/Clavulanate
    PhasePhase 4
    Registry statusCompleted

  • Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment

    NCT03933501 · start 2006-01-01

    Registered record
    Registry ID
    NCT03933501
    Conditions
    Generalized Aggressive Periodontitis
    Interventions
    amoxicillin and metronidazole; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-01-01
    Completion
    2018-12-01
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneralized Aggressive Periodontitis
    Interventionamoxicillin and metronidazole; Placebos
    PhasePhase 4
    Registry statusCompleted

  • Guidelines for Acute Sinusitis

    NCT00132275 · start 2003-11

    Registered record
    Registry ID
    NCT00132275
    Conditions
    Sinusitis
    Interventions
    Amoxicillin potassium clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-11
    Completion
    2006-08
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionAmoxicillin potassium clavulanate
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

    NCT00066066 · start 2003-07

    Registered record
    Registry ID
    NCT00066066
    Conditions
    Periodontitis; Periodontal Diseases
    Interventions
    Scaling and root planing; Metronidazole; Amoxicillin; Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-07
    Completion
    2009-07
    Enrolment
    146

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis; Periodontal Diseases
    InterventionScaling and root planing; Metronidazole; Amoxicillin; Doxycycline
    PhasePhase 2
    Registry statusCompleted