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AMR Drug RepurposingSmart Screeningresearch prototype

Ampicillin Sodium

FDA-approved product (injectable, injection), marketed as Ampicillin Sodium, Omnipen-N, Penbritin-S and 13 more.

Registered studies
50+
Lab records
69
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Ampicillin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Bacterial meningitis
  • Endocarditis
  • Eye infection
  • Gonorrhea
  • Infection
  • Infectious meningitis
  • Sepsis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Penicillins with extended spectrum; Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CA01; WHO ATC J01CA51; WHO ATC S01AA19

Repurposing investigation

Ampicillin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA26.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli29.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae7.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis32.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 5 of 20 lab records
  • E. coli: measured active in 4 of 10 lab records
  • K. pneumoniae: measured active in 12 of 39 lab records
Open Ampicillin Sodium in ChEMBL Registered studies below
Show the 69 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ampicillin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Computer-based Dosage Calculation for Antibiotics

    NCT03036826 · start 2019-06

    Registered record
    Registry ID
    NCT03036826
    Conditions
    Acute Kidney Insufficiency; Anti-Infective Agent Toxicity
    Interventions
    Piperacillin/tazobactam; Meropenem
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Withdrawn
    Start
    2019-06
    Completion
    2021-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Kidney Insufficiency; Anti-Infective Agent Toxicity
    InterventionPiperacillin/tazobactam; Meropenem
    PhaseNot recorded
    Registry statusWithdrawn

  • A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia

    NCT03006679 · start 2018-08

    Registered record
    Registry ID
    NCT03006679
    Conditions
    Hospital-Acquired Bacterial Pneumonia; Ventilator-Associated Bacterial Pneumonia; Hospital-Acquired Pneumonia; Ventilator-Associated Pneumonia
    Interventions
    Meropenem-Vaborbactam; Piperacillin/Tazobactam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2018-08
    Completion
    2020-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHospital-Acquired Bacterial Pneumonia; Ventilator-Associated Bacterial Pneumonia; Hospital-Acquired Pneumonia; Ventilator-Associated Pneumonia
    InterventionMeropenem-Vaborbactam; Piperacillin/Tazobactam
    PhasePhase 3
    Registry statusWithdrawn

  • RCT of Efficacy of Amoxicillin Over Ampicillin on Severe Pneumonia

    NCT03369093 · start 2018-01-01

    Registered record
    Registry ID
    NCT03369093
    Conditions
    Treatment Failure; Lethargy; Altered Mental Status; Convulsion, Non-Epileptic; Hypoxia; Feeding; Difficult, Newborn
    Interventions
    Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-01-01
    Completion
    2019-12-31
    Enrolment
    308

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTreatment Failure; Lethargy; Altered Mental Status; Convulsion, Non-Epileptic +3 more
    InterventionAmoxicillin
    PhaseNot applicable
    Registry statusCompleted

  • Therapeutic Drug Monitoring and Continuous Infusion of Beta-lactam Antibiotics in Patients With Bacteraemia

    NCT03108690 · start 2017-10-01

    Registered record
    Registry ID
    NCT03108690
    Conditions
    Bacteremia
    Interventions
    Continuous infusion of beta-lactam antibiotics .; Therapeutic drug monitoring of beta-lactam antibiotics.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2017-10-01
    Completion
    2023-03-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia
    InterventionContinuous infusion of beta-lactam antibiotics .; Therapeutic drug monitoring of beta-lactam antibiotics.
    PhasePhase 4
    Registry statusWithdrawn

  • Helicobacter Pylori Eradication in Functional Dyspepsia

    NCT04697641 · start 2017-09-01

    Registered record
    Registry ID
    NCT04697641
    Conditions
    Dyspepsia; Helicobacter Pylori Infection
    Interventions
    Clarithromycin 500mg; Amoxicillin 1000 MG; Pantoprazole 40mg; Levosulpiride; Acotiamide; Itopride
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-09-01
    Completion
    2019-05-31
    Enrolment
    202

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDyspepsia; Helicobacter Pylori Infection
    InterventionClarithromycin 500mg; Amoxicillin 1000 MG; Pantoprazole 40mg; Levosulpiride +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES)

    NCT03607734 · start 2017-04-24

    Registered record
    Registry ID
    NCT03607734
    Conditions
    Allergy
    Interventions
    Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-04-24
    Completion
    2017-10-02
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergy
    InterventionAmoxicillin
    PhaseNot applicable
    Registry statusCompleted

  • Tailored H. Pylori Eradication Based on Clarithromycin Resistance

    NCT03884348 · start 2017-01-01

    Registered record
    Registry ID
    NCT03884348
    Conditions
    Helicobacter Pylori Infection; Antibiotic Resistant Strain
    Interventions
    proton pump inhibitor, amoxicillin, clarithromycin; proton pump inhibitor, amoxicillin, metronidazole
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-01-01
    Completion
    2018-12-31
    Enrolment
    431

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection; Antibiotic Resistant Strain
    Interventionproton pump inhibitor, amoxicillin, clarithromycin; proton pump inhibitor, amoxicillin, metronidazole
    PhaseNot recorded
    Registry statusCompleted

  • Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN Study

    NCT03003273 · start 2017-01

    Registered record
    Registry ID
    NCT03003273
    Conditions
    Neutropenia, Febrile; Pediatric Cancer
    Interventions
    stoppage of antibiotics; amoxycillin/clavulanic acid; levofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2017-01
    Completion
    2018-12
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeutropenia, Febrile; Pediatric Cancer
    Interventionstoppage of antibiotics; amoxycillin/clavulanic acid; levofloxacin
    PhasePhase 3
    Registry statusTerminated

  • Helicobacter Pylori Eradication Study

    NCT03130452 · start 2016-12-17

    Registered record
    Registry ID
    NCT03130452
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Lansoprazole 30mg; Amoxicillin 1.0g Tab; Clarithromycin 500mg; Metronidazole 500 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-12-17
    Completion
    2019-05-31
    Enrolment
    423

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionLansoprazole 30mg; Amoxicillin 1.0g Tab; Clarithromycin 500mg; Metronidazole 500 mg
    PhasePhase 4
    Registry statusCompleted

  • Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children

    NCT02848820 · start 2016-12

    Registered record
    Registry ID
    NCT02848820
    Conditions
    Appendicitis
    Interventions
    Augmentin + Gentamicin; Appendectomy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-12
    Completion
    2024-12
    Enrolment
    302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAppendicitis
    InterventionAugmentin + Gentamicin; Appendectomy
    PhasePhase 4
    Registry statusUnknown

  • Safety and Efficacy of Solithromycin in Adolescents and Children With Community-Acquired Bacterial Pneumonia

    NCT02605122 · start 2016-04

    Registered record
    Registry ID
    NCT02605122
    Conditions
    Community-acquired Bacterial Pneumonia
    Interventions
    Solithromycin; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2016-04
    Completion
    2018-03-21
    Enrolment
    97

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-acquired Bacterial Pneumonia
    InterventionSolithromycin; Standard of Care
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients

    NCT02648659 · start 2016-03-02

    Registered record
    Registry ID
    NCT02648659
    Conditions
    Peptic Ulcer
    Interventions
    Ilaprazole; Amoxicillin; Clarithromycin; Metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-03-02
    Completion
    2017-02-14
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeptic Ulcer
    InterventionIlaprazole; Amoxicillin; Clarithromycin; Metronidazole
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone

    NCT02281929 · start 2015-06-13

    Registered record
    Registry ID
    NCT02281929
    Conditions
    Alcoholic Hepatitis; Alcoholic Liver Disease
    Interventions
    Amoxicillin; Placebo; Prednisolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-06-13
    Completion
    2019-11-19
    Enrolment
    297

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholic Hepatitis; Alcoholic Liver Disease
    InterventionAmoxicillin; Placebo; Prednisolone
    PhasePhase 3
    Registry statusCompleted

  • Preschool Wheeze: Inflammation/Infection Guided Management

    NCT02517099 · start 2015-06-05

    Registered record
    Registry ID
    NCT02517099
    Conditions
    Asthma
    Interventions
    Beclometasone; Co-amoxiclav; Azithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-06-05
    Completion
    2018-08-17
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionBeclometasone; Co-amoxiclav; Azithromycin
    PhasePhase 2
    Registry statusCompleted

  • Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response

    NCT02437045 · start 2015-04

    Registered record
    Registry ID
    NCT02437045
    Conditions
    Bloodstream Infections
    Interventions
    Meropenem; Piperacillin-tazobactam combination product
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-04
    Completion
    2020-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBloodstream Infections
    InterventionMeropenem; Piperacillin-tazobactam combination product
    PhasePhase 4
    Registry statusCompleted