Indocyanine Green
FDA-approved product (injectable, injection), marketed as Ic-Green, Indocyanine Green, Spy Agent Green Kit and 1 more.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 2 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLNo approved indication recorded
ChEMBL records no approved indication for Indocyanine Green. Its therapeutic class is shown instead.
- WHO therapeutic group
- Other diagnostic agents
- FDA pharmacologic class
- Diagnostic Dye FDA label ↗
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA41.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli35.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae26.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis58.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Indocyanine Green with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Mefloquine HydrochlorideExisting use: Malaria, Plasmodium falciparum malaria, Plasmodium vivax malaria81.8% AI-predicted activityagainst M. tuberculosisLab records exist8 registered studies
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Anatomy-based Resection or Margin-based Resection for Hepatocellular Carcinoma
NCT03652896 · start 2019-01-01
Registered record
- Registry ID
- NCT03652896
- Conditions
- Hepatocellular Carcinoma by BCLC Stage
- Interventions
- anatomical liver resection
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2019-01-01
- Completion
- 2023-12-30
- Enrolment
- 60
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHepatocellular Carcinoma by BCLC StageInterventionanatomical liver resectionPhaseNot applicableRegistry statusUnknownFlap Fenestration and Facial Organ Fabrication Guided by ICGA
NCT05360355 · start 2018-06-01
Registered record
- Registry ID
- NCT05360355
- Conditions
- Surgery
- Interventions
- total face reconstruction surgery and intraoperative indocyanine green angiography
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2018-06-01
- Completion
- 2021-06-01
- Enrolment
- 10
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSurgeryInterventiontotal face reconstruction surgery and intraoperative indocyanine green angiographyPhaseNot recordedRegistry statusCompletedIndocyanine Green Lymphangiography in Identifying Thoracic Duct During Neck Surgery
NCT03532581 · start 2018-04-23
Registered record
- Registry ID
- NCT03532581
- Conditions
- Neck Dissection; Radical Lymph Node Dissection
- Interventions
- Indocyanine Green Solution; Lymphangiography
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2018-04-23
- Completion
- 2023-03-07
- Enrolment
- 48
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionNeck Dissection; Radical Lymph Node DissectionInterventionIndocyanine Green Solution; LymphangiographyPhaseNot applicableRegistry statusCompletedIndocyanine Green Tissue Perfusion Monitoring
NCT02978560 · start 2018-03-05
Registered record
- Registry ID
- NCT02978560
- Conditions
- Regional Blood Flow; Wound Heal
- Interventions
- fluorescence-mediated photoplethysmography
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2018-03-05
- Completion
- 2018-07-01
- Enrolment
- 15
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionRegional Blood Flow; Wound HealInterventionfluorescence-mediated photoplethysmographyPhaseNot recordedRegistry statusCompletedMechanism of Indocyanine Green-based Photodynamic Therapy for Treating Periodontitis
NCT03557827 · start 2018-03-01
Registered record
- Registry ID
- NCT03557827
- Conditions
- Periodontal Diseases
- Interventions
- Photodynamic Therapy with indocyanine green and diode laser; Mechanical debridement alone
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Unknown
- Start
- 2018-03-01
- Completion
- 2019-12-31
- Enrolment
- 80
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPeriodontal DiseasesInterventionPhotodynamic Therapy with indocyanine green and diode laser; Mechanical debridement alonePhasePhase 3Registry statusUnknownDark Halo and MNV: a Study Between ICGA and OCTA
NCT05108285 · start 2018-01-01
Registered record
- Registry ID
- NCT05108285
- Conditions
- Macular Neovascularisation
- Interventions
- Optical Coherence Tomography Angiography (OCTA) and indocyanine green angiography (ICGA)
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2018-01-01
- Completion
- 2020-12-15
- Enrolment
- 50
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionMacular NeovascularisationInterventionOptical Coherence Tomography Angiography (OCTA) and indocyanine green angiography (ICGA)PhaseNot recordedRegistry statusCompletedFLOTOR Pilot Study
NCT03292757 · start 2017-12-20
Registered record
- Registry ID
- NCT03292757
- Conditions
- Chylothorax; Esophageal Cancer; Thoracic Duct Intra-Operative Injury
- Interventions
- Indocyanine Green
- Study type
- INTERVENTIONAL
- Phase
- Phase 1 / Phase 2
- Registry status
- Completed
- Start
- 2017-12-20
- Completion
- 2018-09-20
- Enrolment
- 21
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChylothorax; Esophageal Cancer; Thoracic Duct Intra-Operative InjuryInterventionIndocyanine GreenPhasePhase 1 / Phase 2Registry statusCompletedObseRvation of PeripHEral rEtinal Morphology in Normals
NCT02091700 · start 2017-03
Registered record
- Registry ID
- NCT02091700
- Conditions
- Healthy
- Interventions
- Indocyanine Green ICG
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Unknown
- Start
- 2017-03
- Completion
- 2017-07
- Enrolment
- 30
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHealthyInterventionIndocyanine Green ICGPhaseNot recordedRegistry statusUnknownApplication of ICG Fluorescence Cholangiography in Laparoscopic Living Donor Left Lateral Sectionectomy
NCT05506020 · start 2016-10
Registered record
- Registry ID
- NCT05506020
- Conditions
- Living Donor Liver Transplantation
- Interventions
- indocyanine green (ICG) fluorescence cholangiography
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2016-10
- Completion
- 2022-07
- Enrolment
- 85
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLiving Donor Liver TransplantationInterventionindocyanine green (ICG) fluorescence cholangiographyPhaseNot applicableRegistry statusCompletedDetection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor
NCT02983786 · start 2015-12
Registered record
- Registry ID
- NCT02983786
- Conditions
- Traumatic Brain Injury; Ischemic Stroke; Intracerebral Hemorrhage; Subarachnoid Hemorrhage; Acute Anoxic Encephalopathy
- Interventions
- Indocyanine Green
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2015-12
- Completion
- 2022-05-25
- Enrolment
- 29
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionTraumatic Brain Injury; Ischemic Stroke; Intracerebral Hemorrhage; Subarachnoid Hemorrhage +1 moreInterventionIndocyanine GreenPhaseNot recordedRegistry statusCompletedEvaluation of Indocyanine Green-guided Systematic Pelvic Lymphadenectomy in Endometrial and Cervical Cancer
NCT04246580 · start 2014-01
Registered record
- Registry ID
- NCT04246580
- Conditions
- Endometrial Cancer; Cervical Cancer
- Interventions
- Indocyanine green-guided systematic pelvic lymphadenectomy
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2014-01
- Completion
- 2022-11
- Enrolment
- 230
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionEndometrial Cancer; Cervical CancerInterventionIndocyanine green-guided systematic pelvic lymphadenectomyPhaseNot recordedRegistry statusCompletedGenetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD)
NCT02762188 · start 2013-08-01
Registered record
- Registry ID
- NCT02762188
- Conditions
- Age-Related Macular Degeneration
- Interventions
- Genotype analysis
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2013-08-01
- Completion
- 2018-01-18
- Enrolment
- 501
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAge-Related Macular DegenerationInterventionGenotype analysisPhaseNot applicableRegistry statusCompletedBiliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CT
NCT01879735 · start 2013-06
Registered record
- Registry ID
- NCT01879735
- Conditions
- Cholestasis; Primary Sclerosing Cholangitis; Primary Biliary Cirrhosis
- Interventions
- 11C-CSar; ICG
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2013-06
- Completion
- 2014-09
- Enrolment
- 22
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCholestasis; Primary Sclerosing Cholangitis; Primary Biliary CirrhosisIntervention11C-CSar; ICGPhasePhase 1Registry statusCompletedLymph Node Mapping Using Indocyanine Green Solution in Diagnosing Patients With Malignant Melanoma
NCT01898403 · start 2013-06
Registered record
- Registry ID
- NCT01898403
- Conditions
- Recurrent Melanoma
- Interventions
- Indocyanine green solution; Isosulfan blue (ISB); Lymphoscintigraphy with 99-technetium (99Tc) sulfur colloid (TSC)
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2013-06
- Completion
- 2015-04
- Enrolment
- 50
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionRecurrent MelanomaInterventionIndocyanine green solution; Isosulfan blue (ISB); Lymphoscintigraphy with 99-technetium (99Tc) sulfur colloid (TSC)PhaseNot applicableRegistry statusCompletedIndocyanine Green (ICG) in the ex Vivo Detection of Sentinel Lymph Node (SLN)in Colon Cancer
NCT01995591 · start 2013-01
Registered record
- Registry ID
- NCT01995591
- Conditions
- Colon Cancer; Colon Surgery
- Interventions
- Not recorded
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2013-01
- Completion
- 2015-02
- Enrolment
- 20
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColon Cancer; Colon SurgeryInterventionNot recordedPhaseNot recordedRegistry statusCompleted