Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Indocyanine Green

FDA-approved product (injectable, injection), marketed as Ic-Green, Indocyanine Green, Spy Agent Green Kit and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Indocyanine Green
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Indocyanine Green. Its therapeutic class is shown instead.

WHO therapeutic group
Other diagnostic agents
FDA pharmacologic class
Diagnostic Dye FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA41.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae26.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Indocyanine Green in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Indocyanine Green with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Magnetic Sentinel Lymph Node Mapping in Gastric Cancer

    NCT05038098 · start 2026-12-31

    Registered record
    Registry ID
    NCT05038098
    Conditions
    Gastric Adenocarcinoma
    Interventions
    Gastrectomy; Indocyanine Green; Iron Conjugated Polymers in Saline Suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Not yet recruiting
    Start
    2026-12-31
    Completion
    2027-02-02
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastric Adenocarcinoma
    InterventionGastrectomy; Indocyanine Green; Iron Conjugated Polymers in Saline Suspension
    PhasePhase 1
    Registry statusNot yet recruiting

  • Randomized Evaluation of Indocyanine Green Fluorescence Angiography-Guided Versus Standard Clinical Perfusion Assessment During Gluteal Permanent Synthetic Filler Removal

    NCT07808957 · start 2026-10-01

    Registered record
    Registry ID
    NCT07808957
    Conditions
    Soft Tissue Filler Complication; Surgical Flap Ischemia; Tissue Necrosis
    Interventions
    Indocyanine Green; Standard Clinical Perfusion Assessment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2027-10-01
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSoft Tissue Filler Complication; Surgical Flap Ischemia; Tissue Necrosis
    InterventionIndocyanine Green; Standard Clinical Perfusion Assessment
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical Assessment for Flap Perfusion in Head and Neck Reconstruction (VISION Trial)

    NCT07635420 · start 2026-09-28

    Registered record
    Registry ID
    NCT07635420
    Conditions
    Head and Neck Cancer (H&N); Free Tissue Flaps; Free Flap; Free Flap Evaluation; Indocyanine Green; Indocyanine Green (ICG); Microsurgery; Randomised Controlled Trial
    Interventions
    Indocyanine Green; Standard clinical perfusion assessment
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-09-28
    Completion
    2029-08-01
    Enrolment
    244

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHead and Neck Cancer (H&N); Free Tissue Flaps; Free Flap; Free Flap Evaluation +4 more
    InterventionIndocyanine Green; Standard clinical perfusion assessment
    PhasePhase 4
    Registry statusRecruiting

  • Deep Cervical Lymphatic Venous Anastomosis in the Treatment of Alzheimer's Disease (CLEAN-AD)

    NCT07073066 · start 2026-03-13

    Registered record
    Registry ID
    NCT07073066
    Conditions
    Alzheimers Disease
    Interventions
    DC-LVA treatment plus usual care; Usual care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-03-13
    Completion
    2029-11-30
    Enrolment
    376

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimers Disease
    InterventionDC-LVA treatment plus usual care; Usual care
    PhaseNot applicable
    Registry statusRecruiting

  • Comparison Between Standard and Reduced Doses of Indocyanine Green in Fluorescence Cholangiography During Laparoscopic Cholecystectomy.

    NCT07195331 · start 2026-02-26

    Registered record
    Registry ID
    NCT07195331
    Conditions
    Laparoscopic Cholecystectomy Surgery
    Interventions
    Intravenous injection of indocianine green at least three hours before surgery at a dose of 2.5 mg per subject.; Intravenous injection of indocianine green 15 to 30 minutes before surgery at a dose of 0.25 mg per subject.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-02-26
    Completion
    2027-01-31
    Enrolment
    122

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaparoscopic Cholecystectomy Surgery
    InterventionIntravenous injection of indocianine green at least three hours before surgery at a dose of 2.5 mg per subject.; Intravenous injection of indocianine green 15 to 30 minutes before surgery at a dose of 0.25 mg per subject.
    PhasePhase 4
    Registry statusRecruiting

  • Using Lymphovenous Bypass to Alleviate Diabetic Peripheral Neuropathy

    NCT07126197 · start 2026-02-11

    Registered record
    Registry ID
    NCT07126197
    Conditions
    Diabetic Peripheral Neuropathy (DPN); Diabetic Peripheral Neuropathic Pain (DPNP); Diabetic Foot Ulcer
    Interventions
    lymphovenous bypass at diseased foot dorsum
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Enrolling by invitation
    Start
    2026-02-11
    Completion
    2026-12-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Peripheral Neuropathy (DPN); Diabetic Peripheral Neuropathic Pain (DPNP); Diabetic Foot Ulcer
    Interventionlymphovenous bypass at diseased foot dorsum
    PhaseNot applicable
    Registry statusEnrolling by invitation

  • Leica Microsystems Sponsored Study to Collect and Confirm Clinical Data on the Performance of the GLOW800 Device When Used in Accordance With Its Intended Use.

    NCT07164040 · start 2026-01-20

    Registered record
    Registry ID
    NCT07164040
    Conditions
    Reconstructive Surgical Procedures; Plastic Surgery; Vascular Surgical Procedure; Cerebrovascular Disorder
    Interventions
    The GLOW800, a non-contact, non-invasive device, allows the surgical microscope ARveo 8 and ARveo 8X to produce excitation light and resolve fluorescence emission from the fluorescent agent ICG
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2026-01-20
    Completion
    2027-07-30
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionReconstructive Surgical Procedures; Plastic Surgery; Vascular Surgical Procedure; Cerebrovascular Disorder
    InterventionThe GLOW800, a non-contact, non-invasive device, allows the surgical microscope ARveo 8 and ARveo 8X to produce excitation light and resolve fluorescence emission from the fluorescent agent ICG
    PhaseNot recorded
    Registry statusRecruiting

  • Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green (ICG) Kinetic Modeling

    NCT06877793 · start 2025-09-26

    Registered record
    Registry ID
    NCT06877793
    Conditions
    Necrotizing Fascitis
    Interventions
    Administration of indocyanine green (ICG) and fluorescence imaging
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2025-09-26
    Completion
    2030-07
    Enrolment
    420

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNecrotizing Fascitis
    InterventionAdministration of indocyanine green (ICG) and fluorescence imaging
    PhaseNot recorded
    Registry statusRecruiting

  • Indocyanine Green Fluoroscopy and SPY Angiography for the Assessment of Lymphatic Structure in Breast Cancer Patients at Risk for Breast Cancer-Related Lymphedema

    NCT06672224 · start 2025-08-14

    Registered record
    Registry ID
    NCT06672224
    Conditions
    Breast Cancer-Related Lymphedema; Breast Carcinoma
    Interventions
    Fluid Therapy; Indocyanine Green; Questionnaire Administration; Research or Clinical Assessment Tool; SPY Elite Fluorescence Imaging; Survey Administration
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2025-08-14
    Completion
    2026-08-14
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer-Related Lymphedema; Breast Carcinoma
    InterventionFluid Therapy; Indocyanine Green; Questionnaire Administration; Research or Clinical Assessment Tool +2 more
    PhaseNot applicable
    Registry statusWithdrawn

  • Prediction of ICG for Skin Necrosis in Mastectomy With Immediate Reconstruction

    NCT06956443 · start 2025-06-01

    Registered record
    Registry ID
    NCT06956443
    Conditions
    Breast Cancers; Mastectomy and Breast Reconstruction; Skin Necrosis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2025-06-01
    Completion
    2026-12-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancers; Mastectomy and Breast Reconstruction; Skin Necrosis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Evaluate the Implementation of Using Indocyanine Green for Sentinel Lymph Node Mapping in Breast Cancer Patients

    NCT07441733 · start 2024-11-07

    Registered record
    Registry ID
    NCT07441733
    Conditions
    Breast Cancer
    Interventions
    ICG used as a tracer for sentinel lymph node; technetium 99 used as a tracer for sentinel lymph node
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-11-07
    Completion
    2026-10
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionICG used as a tracer for sentinel lymph node; technetium 99 used as a tracer for sentinel lymph node
    PhaseNot applicable
    Registry statusRecruiting

  • Selective Sentinella Lymph Node Biopsy with Indocyanine Green in Patients with Breast Cancer

    NCT06378944 · start 2024-01-01

    Registered record
    Registry ID
    NCT06378944
    Conditions
    Breast Cancer
    Interventions
    Application of green indocyanine colorant; Technetium99
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2024-01-01
    Completion
    2029-01-01
    Enrolment
    15,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionApplication of green indocyanine colorant; Technetium99
    PhaseNot recorded
    Registry statusRecruiting

  • Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer Survivorship

    NCT05937269 · start 2023-10-12

    Registered record
    Registry ID
    NCT05937269
    Conditions
    Lymphedema of Face; Head and Neck Cancer
    Interventions
    Near-infrared fluorescence lymphatic imaging; advanced pneumatic compression therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Active not recruiting
    Start
    2023-10-12
    Completion
    2026-10-31
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphedema of Face; Head and Neck Cancer
    InterventionNear-infrared fluorescence lymphatic imaging; advanced pneumatic compression therapy
    PhasePhase 1
    Registry statusActive not recruiting

  • Indocyanine Green for Detection of Sentinel Lymph Nodes In Comparison to ICG Plus Technetium in the Evaluation of Vulvar Squamous Cell Carcinoma

    NCT06039111 · start 2023-10-01

    Registered record
    Registry ID
    NCT06039111
    Conditions
    Vulvar Cancer
    Interventions
    ICG alone
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2023-10-01
    Completion
    2026-11-30
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVulvar Cancer
    InterventionICG alone
    PhaseNot recorded
    Registry statusRecruiting

  • Feasibility and Utility of Artificial Intelligence (AI) / Machine Learning (ML) - Driven Advanced Intraoperative Visualization and Identification of Critical Anatomic Structures and Procedural Phases in Laparoscopic Cholecystectomy

    NCT05775133 · start 2023-08-01

    Registered record
    Registry ID
    NCT05775133
    Conditions
    Cholecystitis; Cholelithiasis; Biliary Dyskinesia
    Interventions
    ICG
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-08-01
    Completion
    2025-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCholecystitis; Cholelithiasis; Biliary Dyskinesia
    InterventionICG
    PhaseNot applicable
    Registry statusUnknown