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AMR Drug RepurposingSmart Screeningresearch prototype

Indocyanine Green

FDA-approved product (injectable, injection), marketed as Ic-Green, Indocyanine Green, Spy Agent Green Kit and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Indocyanine Green
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Indocyanine Green. Its therapeutic class is shown instead.

WHO therapeutic group
Other diagnostic agents
FDA pharmacologic class
Diagnostic Dye FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA41.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae26.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Indocyanine Green in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Indocyanine Green with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • ICG for Visualization of the Ureters in DIE

    NCT05206279 · start 2023-06-26

    Registered record
    Registry ID
    NCT05206279
    Conditions
    Visualization of Ureters in Gynecological Surgery; Deep Infiltrative Endometriosis; ICG (Indocyanine Green); Near Infrared Imaging; Laparoscopy
    Interventions
    Ureteral injection of Indocyanine Green Powder (diluted)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-06-26
    Completion
    2024-09-01
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVisualization of Ureters in Gynecological Surgery; Deep Infiltrative Endometriosis; ICG (Indocyanine Green); Near Infrared Imaging +1 more
    InterventionUreteral injection of Indocyanine Green Powder (diluted)
    PhaseNot applicable
    Registry statusCompleted

  • Applications of Fluorescence Imaging Guided Lymph Node Dissection and Fluorescence Angiography of Inferior Mesenteric Artery Assisted Left Colic Artery Preservation

    NCT06033794 · start 2023-05-01

    Registered record
    Registry ID
    NCT06033794
    Conditions
    Fluorescence; Indocyanine Green; Rectal Cancer Surgery
    Interventions
    Fluorescence laparoscopic system
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-05-01
    Completion
    2024-05-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFluorescence; Indocyanine Green; Rectal Cancer Surgery
    InterventionFluorescence laparoscopic system
    PhaseNot applicable
    Registry statusUnknown

  • Fluorescence-based Detection of Inflammation and Necrosis to Inform Surgical Decision-making and Enhance Outcomes

    NCT05593523 · start 2023-03-09

    Registered record
    Registry ID
    NCT05593523
    Conditions
    Burn Wound
    Interventions
    Indocyanine green (ICG); Clinical Fluorescence Imaging Device
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2023-03-09
    Completion
    2028-03
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurn Wound
    InterventionIndocyanine green (ICG); Clinical Fluorescence Imaging Device
    PhaseNot recorded
    Registry statusActive not recruiting

  • Cost of Using FLUOrescence to Green of Indocyanine for the Detection of Breast Cancer.

    NCT05699291 · start 2023-02-23

    Registered record
    Registry ID
    NCT05699291
    Conditions
    Sentinel Lymph Node
    Interventions
    Sentinel node detection technique
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2023-02-23
    Completion
    2024-05-17
    Enrolment
    163

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSentinel Lymph Node
    InterventionSentinel node detection technique
    PhaseNot recorded
    Registry statusCompleted

  • Performance Assessment of the Fluorescence Technique Alone in the Search for the Sentinel Node in Breast Surgery

    NCT05588414 · start 2022-12-05

    Registered record
    Registry ID
    NCT05588414
    Conditions
    Breast Cancer
    Interventions
    Standardization of the sentinel node detection procedure
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-12-05
    Completion
    2024-06-27
    Enrolment
    392

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionStandardization of the sentinel node detection procedure
    PhaseNot applicable
    Registry statusCompleted

  • A Prospective Single-center Cohort Study "Preoperative Identification of Sentinel Lymph Nodes Using Contrast-enhanced CT Lymphography in Breast Cancer Patients"

    NCT04930692 · start 2022-10-01

    Registered record
    Registry ID
    NCT04930692
    Conditions
    Breast Neoplasms; Sentinel Lymph Node
    Interventions
    Contrast-enhanced CT lymphography with the periareolar injection of iopamidol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-10-01
    Completion
    2023-08-01
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Neoplasms; Sentinel Lymph Node
    InterventionContrast-enhanced CT lymphography with the periareolar injection of iopamidol
    PhaseNot applicable
    Registry statusUnknown

  • Prognostic Role of HVPG and ICG-R15 in the Short- and Medium-term Results of the Surgery of HCC on Cirrhosis

    NCT05800561 · start 2022-01-01

    Registered record
    Registry ID
    NCT05800561
    Conditions
    Hepatocellular Carcinoma
    Interventions
    Hepatic venous-portal gradient (HVPG) measurement
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2022-01-01
    Completion
    2024-01-31
    Enrolment
    208

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatocellular Carcinoma
    InterventionHepatic venous-portal gradient (HVPG) measurement
    PhaseNot recorded
    Registry statusUnknown

  • Indocyanine Green Tracer Using in Laparoscopic Distal Gastrectomy for Early Gastric Cancer

    NCT04973475 · start 2021-07

    Registered record
    Registry ID
    NCT04973475
    Conditions
    Early Gastric Cancer; Indocyanine Green; Lymph Node Dissection
    Interventions
    Indocyanine Green
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2021-07
    Completion
    2026-07
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEarly Gastric Cancer; Indocyanine Green; Lymph Node Dissection
    InterventionIndocyanine Green
    PhasePhase 2
    Registry statusUnknown

  • A Study of Intra-operative Imaging in Women With Ovarian Cancer

    NCT04878094 · start 2021-05-03

    Registered record
    Registry ID
    NCT04878094
    Conditions
    Ovarian Cancer; Ovarian Carcinoma
    Interventions
    Intravenous Indocyanine Green/ICG injection; PINPOINT endoscopic fluorescence imaging system; Endoscopy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Active not recruiting
    Start
    2021-05-03
    Completion
    2027-05-03
    Enrolment
    155

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Cancer; Ovarian Carcinoma
    InterventionIntravenous Indocyanine Green/ICG injection; PINPOINT endoscopic fluorescence imaging system; Endoscopy
    PhasePhase 3
    Registry statusActive not recruiting

  • Sentinel Node Biopsy in Endometrial Cancer

    NCT04073706 · start 2021-01-18

    Registered record
    Registry ID
    NCT04073706
    Conditions
    Endometrial Cancer Stage I; Sentinel Lymph Node; Surgery
    Interventions
    TH BSO with SNB Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted; TH BSO without retroperitoneal node dissection Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2021-01-18
    Completion
    2031-02
    Enrolment
    760

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometrial Cancer Stage I; Sentinel Lymph Node; Surgery
    InterventionTH BSO with SNB Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted; TH BSO without retroperitoneal node dissection Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted
    PhasePhase 3
    Registry statusRecruiting

  • Future of Colorectal Cancer Surgery

    NCT04220242 · start 2019-12-30

    Registered record
    Registry ID
    NCT04220242
    Conditions
    Colorectal Cancer; Surgery
    Interventions
    Video recordings with analysis thereafter applied; Examination of microsections of tissue excised for the purposes of cancer resection; Cancer organoid development and testing
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2019-12-30
    Completion
    2023-03-01
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer; Surgery
    InterventionVideo recordings with analysis thereafter applied; Examination of microsections of tissue excised for the purposes of cancer resection; Cancer organoid development and testing
    PhaseNot recorded
    Registry statusUnknown

  • Hyperbaric Oxygenation in Diabetic Ulcer

    NCT02042339 · start 2019-12

    Registered record
    Registry ID
    NCT02042339
    Conditions
    Diabetes Mellitus
    Interventions
    Hyperbaric oxygen
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2019-12
    Completion
    2022-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus
    InterventionHyperbaric oxygen
    PhasePhase 3
    Registry statusUnknown

  • Use of Indocyanine Green During Pelvic Lymph Node Dissection in Prostate Cancer.

    NCT04882618 · start 2019-11-08

    Registered record
    Registry ID
    NCT04882618
    Conditions
    Prostate Cancer; Lymph Node Metastases
    Interventions
    Indocyanine green
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-11-08
    Completion
    2021-11-08
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer; Lymph Node Metastases
    InterventionIndocyanine green
    PhasePhase 4
    Registry statusUnknown

  • Long-term Outcomes, Recurrence Rates, and Treatment Needs in Polypoidal Choroidal Vasculopathy (PCV)

    NCT03929731 · start 2019-07-05

    Registered record
    Registry ID
    NCT03929731
    Conditions
    Polypoidal Choroidal Vasculopathy
    Interventions
    Indocyanine Green Angiography
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2019-07-05
    Completion
    2024-05-09
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPolypoidal Choroidal Vasculopathy
    InterventionIndocyanine Green Angiography
    PhaseNot recorded
    Registry statusCompleted

  • Effect of Exercise on Indocyanine Green (ICG) Lymphography Imaging

    NCT03584633 · start 2019-04-15

    Registered record
    Registry ID
    NCT03584633
    Conditions
    Lymphedema
    Interventions
    Indocyanine Green
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-04-15
    Completion
    2019-12-31
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphedema
    InterventionIndocyanine Green
    PhasePhase 4
    Registry statusCompleted