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AMR Drug RepurposingSmart Screeningresearch prototype

Hydrocortisone Sodium Phosphate

FDA-approved product (injectable, injection), marketed as Hydrocortone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Hydrocortisone Sodium Phosphate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Adrenal gland disease
  • Adrenocortical insufficiency
  • Allergic conjunctivitis
  • Asthma
  • Atopic eczema
  • Bursitis
  • Cancer
  • Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
  • Congenital adrenal hyperplasia
  • Crohn's disease
  • Dermatitis
  • Endocrine system disease
  • Exanthem
  • Eye inflammation
  • Hemorrhoid
  • Herpes Labialis
  • and 19 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids for local oral treatment; Corticosteroids acting locally; Corticosteroids; Corticosteroids, weak (group i); Corticosteroids, weak, other combinations
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli30.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae25.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis31.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Hydrocortisone Sodium Phosphate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Hydrocortisone Sodium Phosphate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Ramadan Fasting in Patients With Corticotrope Deficiency Treated Either by Hydrocortisone or by Prednisolone

    NCT03585829 · start 2018-05-17

    Registered record
    Registry ID
    NCT03585829
    Conditions
    Corticotropin Deficiency; Fasting
    Interventions
    Hydrocortisone; Prednisolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-05-17
    Completion
    2018-07-25
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCorticotropin Deficiency; Fasting
    InterventionHydrocortisone; Prednisolone
    PhasePhase 4
    Registry statusCompleted

  • Treatment With Combination Chemotherapy for Relapsed or Refractory Acute Lymphoblastic Leukemia

    NCT03515200 · start 2018-04-20

    Registered record
    Registry ID
    NCT03515200
    Conditions
    Acute Lymphoblastic Leukemia, in Relapse; Acute Lymphoblastic Leukemia With Failed Remission
    Interventions
    Palbociclib Oral Capsule; Intrathecal Triple Therapy; Dexamethasone; Bortezomib; Dasatinib; Doxorubicin; Ruxolitinib
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2018-04-20
    Completion
    2020-07-29
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lymphoblastic Leukemia, in Relapse; Acute Lymphoblastic Leukemia With Failed Remission
    InterventionPalbociclib Oral Capsule; Intrathecal Triple Therapy; Dexamethasone; Bortezomib +3 more
    PhasePhase 1
    Registry statusTerminated

  • Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.

    NCT03422159 · start 2018-02-05

    Registered record
    Registry ID
    NCT03422159
    Conditions
    Sepsis, Severe; Septic Shock
    Interventions
    Ascorbic Acid; Thiamine; Hydrocortisone; Sodium Chloride 0.9%
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2018-02-05
    Completion
    2019-08-27
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis, Severe; Septic Shock
    InterventionAscorbic Acid; Thiamine; Hydrocortisone; Sodium Chloride 0.9%
    PhasePhase 2
    Registry statusCompleted

  • The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock

    NCT03335124 · start 2017-09-26

    Registered record
    Registry ID
    NCT03335124
    Conditions
    Sepsis; Septic Shock; Critical Illness; Fluid Overload
    Interventions
    Vitamin C; Hydrocortisone; Thiamine; 0.9% Sodium Chloride Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-09-26
    Completion
    2018-12-01
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis; Septic Shock; Critical Illness; Fluid Overload
    InterventionVitamin C; Hydrocortisone; Thiamine; 0.9% Sodium Chloride Injection
    PhasePhase 4
    Registry statusTerminated

  • Topical Hydrocortisone for Pain and Edema Control After Third Molar Surgery

    NCT03179813 · start 2017-05-01

    Registered record
    Registry ID
    NCT03179813
    Conditions
    Impacted Third Molar Tooth
    Interventions
    Hydrocortisone; Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-05-01
    Completion
    2018-03-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImpacted Third Molar Tooth
    InterventionHydrocortisone; Control
    PhasePhase 4
    Registry statusCompleted

  • The Effect of Cortisol Administration on Neural Correlates of Emotion in Depression

    NCT02837432 · start 2016-07

    Registered record
    Registry ID
    NCT02837432
    Conditions
    Depression
    Interventions
    Hydrocortisone acetate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2016-07
    Completion
    2020-11-15
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression
    InterventionHydrocortisone acetate; Placebo
    PhaseEarly phase 1
    Registry statusCompleted

  • A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma

    NCT01614197 · start 2015-07-03

    Registered record
    Registry ID
    NCT01614197
    Conditions
    Lymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Lymphoma; Peripheral T-cell Lymphoma
    Interventions
    Temsirolimus; Etoposide; Cyclophosphamide; Methotrexate; Hydrocortisone; Cytarabine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-07-03
    Completion
    2020-09-04
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Lymphoma; Peripheral T-cell Lymphoma
    InterventionTemsirolimus; Etoposide; Cyclophosphamide; Methotrexate +2 more
    PhasePhase 1
    Registry statusCompleted

  • Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception

    NCT02691858 · start 2015-04

    Registered record
    Registry ID
    NCT02691858
    Conditions
    Intussusception
    Interventions
    Hydrocortisone; Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2015-04
    Completion
    2025-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntussusception
    InterventionHydrocortisone; Saline
    PhaseNot applicable
    Registry statusUnknown

  • Treatment of Adrenal Insufficiency in Children

    NCT02720952 · start 2015-03

    Registered record
    Registry ID
    NCT02720952
    Conditions
    Adrenal Insufficiency
    Interventions
    Infacort®
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-03
    Completion
    2016-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdrenal Insufficiency
    InterventionInfacort®
    PhasePhase 3
    Registry statusCompleted

  • Effect of Slow Release Hydrocortisone on Fed & Fasting Volunteers; Immediate Release on Fasting Only

    NCT02408068 · start 2015-01

    Registered record
    Registry ID
    NCT02408068
    Conditions
    Healthy
    Interventions
    Dexamethasone; Chronocort: fasted; Immediate release hydrocortisone: fasted; Chronocort: fed
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-01
    Completion
    2015-03
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionDexamethasone; Chronocort: fasted; Immediate release hydrocortisone: fasted; Chronocort: fed
    PhasePhase 1
    Registry statusCompleted

  • Supplemental Corticosteroids in Cirrhotic Hypotensive Patients With Suspicion of Sepsis

    NCT02602210 · start 2015-01

    Registered record
    Registry ID
    NCT02602210
    Conditions
    Liver Cirrhosis
    Interventions
    Hydrocortisone; NaCL 0.9%
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-01
    Completion
    2020-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Cirrhosis
    InterventionHydrocortisone; NaCL 0.9%
    PhasePhase 3
    Registry statusTerminated

  • Treatment of Tracheostomy Granulomas

    NCT02116608 · start 2014-09

    Registered record
    Registry ID
    NCT02116608
    Conditions
    Granuloma; Tracheostomy
    Interventions
    Betadine; Silver Nitrate; Hydrocortisone Butyrate Cream, 1.0%
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-09
    Completion
    2019-09-05
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGranuloma; Tracheostomy
    InterventionBetadine; Silver Nitrate; Hydrocortisone Butyrate Cream, 1.0%
    PhasePhase 4
    Registry statusCompleted

  • Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study

    NCT02044159 · start 2014-07

    Registered record
    Registry ID
    NCT02044159
    Conditions
    Shock
    Interventions
    Hydrocortisone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-07
    Completion
    2016-04
    Enrolment
    57

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShock
    InterventionHydrocortisone; Placebo
    PhasePhase 4
    Registry statusCompleted

  • A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics

    NCT02270827 · start 2014-06

    Registered record
    Registry ID
    NCT02270827
    Conditions
    Asthma
    Interventions
    Aminophylline; Hydrocortisone
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2014-06
    Completion
    2015-02
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionAminophylline; Hydrocortisone
    PhaseNot recorded
    Registry statusTerminated

  • Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia

    NCT02096510 · start 2014-03-27

    Registered record
    Registry ID
    NCT02096510
    Conditions
    Addison Disease; Adrenal Hyperplasia Congenital
    Interventions
    Solu-Cortef; Cortef
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2014-03-27
    Completion
    2017-12
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAddison Disease; Adrenal Hyperplasia Congenital
    InterventionSolu-Cortef; Cortef
    PhasePhase 1 / Phase 2
    Registry statusCompleted