Vecuronium Bromide
FDA-approved product (injectable, injection), marketed as Norcuron, Vecuronium Bromide.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLNo approved indication recorded
ChEMBL records no approved indication for Vecuronium Bromide. Its therapeutic class is shown instead.
- WHO therapeutic group
- Other quaternary ammonium compounds
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA53.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli31.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae42.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- M. tuberculosis42.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Vecuronium Bromide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Galantamine HydrobromideExisting use: Alzheimer disease, Dementia89.6% AI-predicted activityagainst K. pneumoniaeLab records exist50+ registered studies
- Chlorhexidine GluconateExisting use: Eye infection, Gingivitis, Infection and 2 more69.3% AI-predicted activityagainst K. pneumoniaeLab records exist50+ registered studies
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives68.0% AI-predicted activityagainst K. pneumoniaeLab records exist50+ registered studies
- ElvitegravirExisting use: HIV infection, HIV-1 infection, Viral disease60.2% AI-predicted activityagainst K. pneumoniae50+ registered studies
- Caspofungin AcetateExisting use: Aspergillosis, Candidemia, Candidiasis and 1 more57.5% AI-predicted activityagainst K. pneumoniae50+ registered studies
- DactinomycinExisting use: Kidney Wilms tumor, Neoplasm56.8% AI-predicted activityagainst K. pneumoniae50+ registered studies
- CyclosporineExisting use: Conjunctivitis, Corneal disease, Eye disease and 6 more56.1% AI-predicted activityagainst K. pneumoniae50+ registered studies
- LinaclotideExisting use: Constipation, Constipation disorder, Irritable bowel syndrome56.0% AI-predicted activityagainst K. pneumoniae50+ registered studies
- Irinotecan HydrochlorideExisting use: Adenocarcinoma, Cancer, Carcinoma and 4 more54.5% AI-predicted activityagainst K. pneumoniae50+ registered studies
- OxytocinExisting use: Hemorrhage, Uterine Inertia52.7% AI-predicted activityagainst K. pneumoniae50+ registered studies
- Micafungin SodiumExisting use: Candidiasis52.4% AI-predicted activityagainst K. pneumoniae50+ registered studies
- VoclosporinExisting use: Immune system disease, Lupus nephritis52.2% AI-predicted activityagainst K. pneumoniae28 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Tracheal Colonization and Outcome After Major Abdominal Cancer Surgery
NCT04002128 · start 2008-01
Registered record
- Registry ID
- NCT04002128
- Conditions
- Colorectal Neoplasms Malignant; Surgical Procedures, Operative; Stomach Neoplasms; Pancreatic Cancer, Adult
- Interventions
- Tracheal aspirates and nasal smears were taken in all the patients. Laparotomies were performed in all patients.
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2008-01
- Completion
- 2012-03
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal Neoplasms Malignant; Surgical Procedures, Operative; Stomach Neoplasms; Pancreatic Cancer, AdultInterventionTracheal aspirates and nasal smears were taken in all the patients. Laparotomies were performed in all patients.PhaseNot applicableRegistry statusCompletedA Bridging Trial Comparing Sugammadex (Org 25969) at 1-2 Post-Tetanic Count (PTC) in Japanese Participants. Part A (P05957)
NCT00591786 · start 2005-12-05
Registered record
- Registry ID
- NCT00591786
- Conditions
- Anesthesia, General
- Interventions
- Sugammadex
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2005-12-05
- Completion
- 2006-10-19
- Enrolment
- 100
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAnesthesia, GeneralInterventionSugammadexPhasePhase 2Registry statusCompletedComparison of Sugammadex (Org 25969) With Neostigmine as Reversal Agents for Rocuronium or Vecuronium at Reappearance of T2 (P05960)
NCT00451217 · start 2005-11-17
Registered record
- Registry ID
- NCT00451217
- Conditions
- Anesthesia, General
- Interventions
- Sugammadex; Neostigmine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-11-17
- Completion
- 2006-03-06
- Enrolment
- 198
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAnesthesia, GeneralInterventionSugammadex; NeostigminePhasePhase 3Registry statusCompletedA Bridging Trial Comparing Sugammadex (Org 25969) at 1-2 Post-Tetanic Count (PTC) in Caucasian Participants. Part B (P05974)
NCT00552929 · start 2005-10-04
Registered record
- Registry ID
- NCT00552929
- Conditions
- Anesthesia, General
- Interventions
- Sugammadex
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2005-10-04
- Completion
- 2006-09-15
- Enrolment
- 102
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAnesthesia, GeneralInterventionSugammadexPhasePhase 2Registry statusCompletedComparative Study of Rocuronium With Vecuronium (Study 71101)(COMPLETED)
NCT00970762 · start 2003-02
Registered record
- Registry ID
- NCT00970762
- Conditions
- Anesthesia
- Interventions
- Rocuronium 0.6 mg/kg intubating dose; Rocuronium 0.9 mg/kg intubating dose; Rocuronium 0.1 mg/kg maintenance dose; Rocuronium 0.15 mg/kg maintenance dose; Rocuronium 0.2 mg/kg maintenance; Vecuronium 0.1 mg/kg intubating dose; Vecuronium 0.025 mg/kg maintenance dose
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2003-02
- Completion
- 2004-02
- Enrolment
- 90
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAnesthesiaInterventionRocuronium 0.6 mg/kg intubating dose; Rocuronium 0.9 mg/kg intubating dose; Rocuronium 0.1 mg/kg maintenance dose; Rocuronium 0.15 mg/kg maintenance dose +3 morePhasePhase 3Registry statusCompleted