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AMR Drug RepurposingSmart Screeningresearch prototype

Vecuronium Bromide

FDA-approved product (injectable, injection), marketed as Norcuron, Vecuronium Bromide.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Vecuronium Bromide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Vecuronium Bromide. Its therapeutic class is shown instead.

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA53.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli31.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae42.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis42.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Vecuronium Bromide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-3.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Vecuronium Bromide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Anesthetic Methods and Gene Expression Profile

    NCT03585647 · start 2014-09-15

    Registered record
    Registry ID
    NCT03585647
    Conditions
    Hip Arthroplasty
    Interventions
    hip arthroplasty
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-09-15
    Completion
    2016-11-30
    Enrolment
    99

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Arthroplasty
    Interventionhip arthroplasty
    PhaseNot recorded
    Registry statusCompleted

  • The Effect of Dexmedetomidine to Cognition of Geriatrics in Prolonged Surgery

    NCT02123355 · start 2014-08

    Registered record
    Registry ID
    NCT02123355
    Conditions
    Cognitive Ability, General; Brain Injury
    Interventions
    Induction of anesthesia; Intubation; Sevoflurane, remifentanil ,vecuronium; Dexmedetomidine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-08
    Completion
    2014-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCognitive Ability, General; Brain Injury
    InterventionInduction of anesthesia; Intubation; Sevoflurane, remifentanil ,vecuronium; Dexmedetomidine +1 more
    PhasePhase 4
    Registry statusUnknown

  • Mask Ventilation Before and After Neuromuscular Blockade

    NCT02237443 · start 2014-08

    Registered record
    Registry ID
    NCT02237443
    Conditions
    Anesthesia
    Interventions
    Rocuronium; Vecuronium Bromide; Succinylcholine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-08
    Completion
    2015-02
    Enrolment
    210

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia
    InterventionRocuronium; Vecuronium Bromide; Succinylcholine
    PhasePhase 4
    Registry statusCompleted

  • The Effect of Desflurane on Myocardial Function in Patients Undergoing Coronary Artery Bypass Grafting

    NCT02213718 · start 2014-07

    Registered record
    Registry ID
    NCT02213718
    Conditions
    Coronary Artery Bypass Graft Redo; General Anesthetic Drug Adverse Reaction
    Interventions
    Desflurane; propofol; sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-07
    Completion
    2017-06
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Bypass Graft Redo; General Anesthetic Drug Adverse Reaction
    InterventionDesflurane; propofol; sufentanil
    PhasePhase 4
    Registry statusUnknown

  • The Effect of TEAS on the Quality of Early Recovery

    NCT02619578 · start 2013-11

    Registered record
    Registry ID
    NCT02619578
    Conditions
    C.Delivery; Surgery (Previous), Gynecological; Inappropriate Device Stimulation of Tissue; Delayed Emergence From Anesthesia
    Interventions
    TEAS; Con; propofol, remifentanil, vecuronium; mechanical ventilation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-11
    Completion
    2014-11
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionC.Delivery; Surgery (Previous), Gynecological; Inappropriate Device Stimulation of Tissue; Delayed Emergence From Anesthesia
    InterventionTEAS; Con; propofol, remifentanil, vecuronium; mechanical ventilation
    PhaseNot applicable
    Registry statusCompleted

  • A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia

    NCT02190903 · start 2013-10

    Registered record
    Registry ID
    NCT02190903
    Conditions
    Postoperative Complications; Hip Fracture; Delirium
    Interventions
    General endotracheal anesthesia; Regional (spinal) Anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-10
    Completion
    2015-04
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Complications; Hip Fracture; Delirium
    InterventionGeneral endotracheal anesthesia; Regional (spinal) Anesthesia
    PhaseNot applicable
    Registry statusCompleted

  • A Study of Residual Curarization Incidence in China

    NCT01690338 · start 2012-10

    Registered record
    Registry ID
    NCT01690338
    Conditions
    Perioperative/Postoperative Complications; PORC (Postoperative Residual Curarization)
    Interventions
    Vecuronium Bromide; Rocuronium; Cisatracurium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-10
    Completion
    2014-12
    Enrolment
    6,090

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerioperative/Postoperative Complications; PORC (Postoperative Residual Curarization)
    InterventionVecuronium Bromide; Rocuronium; Cisatracurium
    PhasePhase 4
    Registry statusUnknown

  • Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery

    NCT01690364 · start 2012-07

    Registered record
    Registry ID
    NCT01690364
    Conditions
    Motor Evoked Potential Monitoring; General Anesthesia; Neurosurgery; Brain Tumor; Spine Tumor; Cerebral Aneurysm
    Interventions
    MEP monitoring with continuous infusion of vecuronium during general anesthesia; MEP monitoring with continuous infusion of cisatracurium during general anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-07
    Completion
    2013-03
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMotor Evoked Potential Monitoring; General Anesthesia; Neurosurgery; Brain Tumor +2 more
    InterventionMEP monitoring with continuous infusion of vecuronium during general anesthesia; MEP monitoring with continuous infusion of cisatracurium during general anesthesia
    PhaseNot applicable
    Registry statusCompleted

  • Influence of Cardiopulmonary Bypass, and Sevoflurane or Propofol Anesthesia, on Tissue Oxygen Saturation.

    NCT02593448 · start 2012-03

    Registered record
    Registry ID
    NCT02593448
    Conditions
    NIR Spectroscopy
    Interventions
    NIRS during VOT; General anaesthesia with propofol use; General anaesthesia with sevoflurane use
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-03
    Completion
    2014-08
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNIR Spectroscopy
    InterventionNIRS during VOT; General anaesthesia with propofol use; General anaesthesia with sevoflurane use
    PhasePhase 4
    Registry statusCompleted

  • Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

    NCT01431326 · start 2011-11

    Registered record
    Registry ID
    NCT01431326
    Conditions
    Adenovirus; Anesthesia; Anxiety; Anxiolysis; Autism; Autistic Disorder; Bacterial Meningitis; Bacterial Septicemia; Benzodiazepine; Bipolar Disorder; Bone and Joint Infections; Central Nervous System Infections; Convulsions; Cytomegalovirus Retinitis; Early-onset Schizophrenia Spectrum Disorders; Epilepsy; General Anesthesia; Gynecologic Infections; Herpes Simplex Virus; Infantile Hemangioma; Infection; Inflammation; Inflammatory Conditions; Intra-abdominal Infections; Lower Respiratory Tract Infections; Migraines; Pain; Pneumonia; Schizophrenia; Sedation; Seizures; Skeletal Muscle Spasms; Skin and Skin-structure Infections; Treatment-resistant Schizophrenia; Urinary Tract Infections; Withdrawal; Sepsis; Gram-negative Infection; Bradycardia; Cardiac Arrest; Cardiac Arrhythmia; Staphylococcal Infections; Nosocomial Pneumonia; Neuromuscular Blockade; Methicillin Resistant Staphylococcus Aureus; Endocarditis; Neutropenia; Headache; Fibrinolytic Bleeding; Pulmonary Arterial Hypertension; C
    Interventions
    The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-11
    Completion
    2019-11
    Enrolment
    3,520

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenovirus; Anesthesia; Anxiety; Anxiolysis +47 more
    InterventionThe POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
    PhaseNot recorded
    Registry statusCompleted

  • Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)

    NCT01422304 · start 2011-10-12

    Registered record
    Registry ID
    NCT01422304
    Conditions
    Neuromuscular Blockade; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Coagulation; Antithrombotic Agents
    Interventions
    Sugammadex; neostigmine and glycopyrrolate or atropine; Placebo to neostigmine; Placebo to sugammadex
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-10-12
    Completion
    2012-09-26
    Enrolment
    1,198

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Coagulation +1 more
    InterventionSugammadex; neostigmine and glycopyrrolate or atropine; Placebo to neostigmine; Placebo to sugammadex
    PhasePhase 3
    Registry statusCompleted

  • Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia

    NCT01379352 · start 2011-06

    Registered record
    Registry ID
    NCT01379352
    Conditions
    Liver Transplantation
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-06
    Completion
    2011-12
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Transplantation
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Strategy for Maintaining Partial Neuromuscular Blocking Adequate for Motor Evoked Potential During Neurosurgery

    NCT01388868 · start 2011-06

    Registered record
    Registry ID
    NCT01388868
    Conditions
    Brain Surgery With Motor Evoked Potential Monitoring; Spine Surgery With Motor Evoked Potential Monitoring
    Interventions
    TOF count guided adjustment; T1/ T0 guided adjustment; T2/ T0 guided adjustment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-06
    Completion
    2012-02
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBrain Surgery With Motor Evoked Potential Monitoring; Spine Surgery With Motor Evoked Potential Monitoring
    InterventionTOF count guided adjustment; T1/ T0 guided adjustment; T2/ T0 guided adjustment
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Propofol on Renal Injury in Patients Undergoing Valvular Heart Surgery

    NCT01384643 · start 2011-05

    Registered record
    Registry ID
    NCT01384643
    Conditions
    Heart Valve Disease
    Interventions
    Propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-05
    Completion
    2012-05
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Valve Disease
    InterventionPropofol
    PhasePhase 4
    Registry statusCompleted

  • Nasotracheal Intubation Using Shikani Optical Stylet

    NCT00963677 · start 2009-07

    Registered record
    Registry ID
    NCT00963677
    Conditions
    Intubation; Difficult
    Interventions
    Nasotracheal Intubation through seeing optical stylet (SOS)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-07
    Completion
    2010-11
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntubation; Difficult
    InterventionNasotracheal Intubation through seeing optical stylet (SOS)
    PhaseNot applicable
    Registry statusCompleted