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AMR Drug RepurposingSmart Screeningresearch prototype

Voclosporin

FDA-approved product (capsule, oral), marketed as Lupkynis.

Registered studies
28
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Voclosporin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Immune system disease
  • Lupus nephritis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Calcineurin inhibitors
FDA pharmacologic class
Calcineurin Inhibitor Immunosuppressant FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA60.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli49.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae52.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis51.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

28registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Voclosporin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Voclosporin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Aurinia Renal Response in Active Lupus With Voclosporin

    NCT03021499 · start 2017-05-17

    Registered record
    Registry ID
    NCT03021499
    Conditions
    Lupus Nephritis
    Interventions
    Voclosporin; Placebo Oral Capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-05-17
    Completion
    2019-10-10
    Enrolment
    358

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLupus Nephritis
    InterventionVoclosporin; Placebo Oral Capsule
    PhasePhase 3
    Registry statusCompleted

  • Voclosporin in Healthy Japanese Volunteers

    NCT02949999 · start 2016-10

    Registered record
    Registry ID
    NCT02949999
    Conditions
    Volunteers
    Interventions
    Voclosporin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-10
    Completion
    2016-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVolunteers
    InterventionVoclosporin
    PhasePhase 1
    Registry statusCompleted

  • Aurinia Early Urinary Protein Reduction Predicts Response

    NCT02949973 · start 2015-06

    Registered record
    Registry ID
    NCT02949973
    Conditions
    Lupus Nephritis
    Interventions
    voclosporin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-06
    Completion
    2017-02-17
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLupus Nephritis
    Interventionvoclosporin
    PhasePhase 2
    Registry statusCompleted

  • AURA-LV: Aurinia Urinary Protein Reduction Active - Lupus With Voclosporin (AURA-LV)

    NCT02141672 · start 2014-06

    Registered record
    Registry ID
    NCT02141672
    Conditions
    Lupus Nephritis
    Interventions
    Voclosporin High Dose; Voclosporin Low Dose; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-06
    Completion
    2017-01
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLupus Nephritis
    InterventionVoclosporin High Dose; Voclosporin Low Dose; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Safety and Efficacy Study of Voclosporin and Tacrolimus in Transplantation

    NCT01586845 · start 2013-03

    Registered record
    Registry ID
    NCT01586845
    Conditions
    Renal Transplantation
    Interventions
    voclosporin; tacrolimus
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2013-03
    Completion
    2015-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Transplantation
    Interventionvoclosporin; tacrolimus
    PhasePhase 3
    Registry statusWithdrawn

  • Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis

    NCT01243983 · start 2011-02

    Registered record
    Registry ID
    NCT01243983
    Conditions
    Noninfectious Uveitis
    Interventions
    LX211
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-02
    Completion
    2012-12
    Enrolment
    155

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNoninfectious Uveitis
    InterventionLX211
    PhasePhase 3
    Registry statusCompleted

  • A Dose-Escalation Study to Assess the Safety and Tolerability of LX214 Ophthalmic Solution in Healthy Volunteers, Followed by an Open-Label Evaluation of LX214 in Patients With Keratoconjunctivitis Sicca (KCS)

    NCT00851734 · start 2009-02

    Registered record
    Registry ID
    NCT00851734
    Conditions
    Keratoconjunctivitis Sicca
    Interventions
    voclosporin ophthalmic solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-02
    Completion
    2009-04
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeratoconjunctivitis Sicca
    Interventionvoclosporin ophthalmic solution
    PhasePhase 1
    Registry statusCompleted

  • COronary Native Artery First in Man Investigation of ISA 247 Elution to Prevent Restenotic Mechanisms (CONFIRM 1)

    NCT00689767 · start 2008-06

    Registered record
    Registry ID
    NCT00689767
    Conditions
    Coronary Artery Disease
    Interventions
    CINATRA™ Coronary Stent System; CINATRA™ ISA 247 Coated Coronary Stent System
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-06
    Completion
    2012-07
    Enrolment
    103

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease
    InterventionCINATRA™ Coronary Stent System; CINATRA™ ISA 247 Coated Coronary Stent System
    PhaseNot applicable
    Registry statusTerminated

  • Randomized, Placebo and Ciclosporin Controlled Study of ISA247 in Plaque Psoriasis Patients

    NCT00408187 · start 2006-12

    Registered record
    Registry ID
    NCT00408187
    Conditions
    Psoriasis
    Interventions
    voclosporin; Ciclosporin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-12
    Completion
    2008-12
    Enrolment
    642

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis
    Interventionvoclosporin; Ciclosporin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Study of ISA247 (Voclosporin) in De Novo Renal Transplantation

    NCT00270634 · start 2006-01

    Registered record
    Registry ID
    NCT00270634
    Conditions
    Kidney Diseases
    Interventions
    Voclosporin; tacrolimus
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-01
    Completion
    2009-07
    Enrolment
    334

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Diseases
    InterventionVoclosporin; tacrolimus
    PhasePhase 2
    Registry statusCompleted

  • A 36-Week Extension to Protocol ISA04-03

    NCT00258713 · start 2005-09

    Registered record
    Registry ID
    NCT00258713
    Conditions
    Psoriasis
    Interventions
    voclosporin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-09
    Completion
    2006-07
    Enrolment
    309

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis
    Interventionvoclosporin
    PhasePhase 3
    Registry statusCompleted

  • Randomized Placebo-controlled Study of ISA247 in Plaque Psoriasis

    NCT00244842 · start 2004-12

    Registered record
    Registry ID
    NCT00244842
    Conditions
    Psoriasis
    Interventions
    voclosporin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-12
    Completion
    2005-10
    Enrolment
    451

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis
    Interventionvoclosporin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Special Access for the Use of Voclosporin for Kidney Transplantation

    NCT01236287

    Registered record
    Registry ID
    NCT01236287
    Conditions
    Immunosuppression; Transplantation, Kidney
    Interventions
    Voclosporin
    Study type
    EXPANDED_ACCESS
    Phase
    Not recorded
    Registry status
    No longer available
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImmunosuppression; Transplantation, Kidney
    InterventionVoclosporin
    PhaseNot recorded
    Registry statusNo longer available