Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Fosinopril Sodium

FDA-approved product (tablet, oral), marketed as Fosinopril Sodium, Monopril.

Registered studies
21
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Fosinopril Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Heart failure
  • Hypertension

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Ace inhibitors, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA36.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli42.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae30.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis47.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

21registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Fosinopril Sodium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Fosinopril Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)

    NCT07547878 · start 2026-04-30

    Registered record
    Registry ID
    NCT07547878
    Conditions
    Chronic Kidney Disease; Type 2 Diabetes
    Interventions
    Finerenone; Semaglutide; Lotensin; Capoten; Enalapril; Monopril; Lisinopril; Univasc; Aceon; Accupril; Altace; Mavik; Edarbi; Atacand; Avapro; Cozaar; Benicar; Micardis; Diovan; Invokana; Farxiga; Jardiance; Ertugliflozin; Brenzavvy; Sotagliflozin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-04-30
    Completion
    2029-03-31
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease; Type 2 Diabetes
    InterventionFinerenone; Semaglutide; Lotensin; Capoten +21 more
    PhasePhase 4
    Registry statusNot yet recruiting

  • Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study

    NCT07262710 · start 2025-12-01

    Registered record
    Registry ID
    NCT07262710
    Conditions
    Post-stroke Pneumonia
    Interventions
    angiotensin converting enzyme inhibitors; Calcium Channel Blockers; Angiotensin Receptor Blockers
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2025-12-01
    Completion
    2026-08-19
    Enrolment
    13,656

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-stroke Pneumonia
    Interventionangiotensin converting enzyme inhibitors; Calcium Channel Blockers; Angiotensin Receptor Blockers
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Effect of Sacubitril/Valsartan on Cardiac Function in Hypertensive Patients Stratified by BMI: A Real World Study

    NCT05498675 · start 2021-09-01

    Registered record
    Registry ID
    NCT05498675
    Conditions
    Sacubitril/Valsartan; Hypertension; Obesity
    Interventions
    Sacubitril / Valsartan Oral Tablet [Entresto]; ACEI/ARB
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2021-09-01
    Completion
    2027-06-30
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSacubitril/Valsartan; Hypertension; Obesity
    InterventionSacubitril / Valsartan Oral Tablet [Entresto]; ACEI/ARB
    PhaseNot recorded
    Registry statusRecruiting

  • Coronavirus (COVID-19) ACEi/ARB Investigation

    NCT04330300 · start 2020-04-30

    Registered record
    Registry ID
    NCT04330300
    Conditions
    Hypertension; COVID-19
    Interventions
    Thiazide or Thiazide-like diuretics; Calcium Channel Blockers; ACE inhibitor; Angiotensin receptor blocker
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Suspended
    Start
    2020-04-30
    Completion
    2021-12-01
    Enrolment
    2,414

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; COVID-19
    InterventionThiazide or Thiazide-like diuretics; Calcium Channel Blockers; ACE inhibitor; Angiotensin receptor blocker
    PhasePhase 4
    Registry statusSuspended

  • ACEI or ARB and COVID-19 Severity and Mortality in US Veterans

    NCT04467931 · start 2020-01-19

    Registered record
    Registry ID
    NCT04467931
    Conditions
    Hypertension; COVID
    Interventions
    ACEI/ARB; Non-ACEI/ARB; ACEI; ARB
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-01-19
    Completion
    2020-12-31
    Enrolment
    22,213

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; COVID
    InterventionACEI/ARB; Non-ACEI/ARB; ACEI; ARB
    PhaseNot recorded
    Registry statusCompleted

  • Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension

    NCT02646397 · start 2016-02

    Registered record
    Registry ID
    NCT02646397
    Conditions
    Chronic Kidney Disease
    Interventions
    Fosinopril; Benidipine; Hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-02
    Completion
    2017-12
    Enrolment
    508

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease
    InterventionFosinopril; Benidipine; Hydrochlorothiazide
    PhasePhase 4
    Registry statusUnknown

  • NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

    NCT02817360 · start 2016-02

    Registered record
    Registry ID
    NCT02817360
    Conditions
    Heart Diseases; Diabetes Mellitus, Type 2
    Interventions
    RAS-antagonist and beta-blocker up-to maximal dosages; RAS-antagonist and beta-blocker none or at stable dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2016-02
    Completion
    2026-12
    Enrolment
    2,400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Diseases; Diabetes Mellitus, Type 2
    InterventionRAS-antagonist and beta-blocker up-to maximal dosages; RAS-antagonist and beta-blocker none or at stable dose
    PhasePhase 4
    Registry statusRecruiting

  • Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery

    NCT01669434 · start 2015-06-01

    Registered record
    Registry ID
    NCT01669434
    Conditions
    Hypotension on Induction
    Interventions
    ACEI continuation; ACEI omission
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-06-01
    Completion
    2016-12-01
    Enrolment
    291

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypotension on Induction
    InterventionACEI continuation; ACEI omission
    PhasePhase 4
    Registry statusCompleted

  • ACE-Inhibitor Effects on Total Hip and Knee Arthroplasty Patients

    NCT01867047 · start 2013-06

    Registered record
    Registry ID
    NCT01867047
    Conditions
    Adverse Effects of Angiotensin-converting-enzyme Inhibitors; Hypotension
    Interventions
    ACE-I Cessation group; ACE-I Continuation group
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2013-06
    Completion
    2016-06-24
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdverse Effects of Angiotensin-converting-enzyme Inhibitors; Hypotension
    InterventionACE-I Cessation group; ACE-I Continuation group
    PhaseNot applicable
    Registry statusTerminated

  • Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics

    NCT01715584 · start 2012-07

    Registered record
    Registry ID
    NCT01715584
    Conditions
    Hypertension
    Interventions
    Sevoflurane/oxygen/air/nitrous oxide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-07
    Completion
    2019-12-31
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionSevoflurane/oxygen/air/nitrous oxide
    PhasePhase 4
    Registry statusUnknown

  • Angiotensin-converting Enzyme (ACE)-Inhibition and Mechanisms of Skeletal Muscle Weakness in Chronic Obstructive Pulmonary Disease (COPD)

    NCT01014338 · start 2009-10

    Registered record
    Registry ID
    NCT01014338
    Conditions
    Chronic Obstructive Pulmonary Disease
    Interventions
    Fosinopril; lactose
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-10
    Completion
    2012-09
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease
    InterventionFosinopril; lactose
    PhasePhase 4
    Registry statusCompleted

  • Eplerenone, ACE Inhibition and Albuminuria

    NCT00315016 · start 2007-01

    Registered record
    Registry ID
    NCT00315016
    Conditions
    Diabetic Nephropathy
    Interventions
    eplerenone; fosinopril; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-01
    Completion
    2011-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Nephropathy
    Interventioneplerenone; fosinopril; placebo
    PhasePhase 2
    Registry statusCompleted

  • The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension

    NCT01342614 · start 2006-05

    Registered record
    Registry ID
    NCT01342614
    Conditions
    Diabetes Mellitus; Essential Hypertension
    Interventions
    Fosinopril; Metformin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-05
    Completion
    2009-08
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus; Essential Hypertension
    InterventionFosinopril; Metformin
    PhaseNot applicable
    Registry statusCompleted

  • Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3

    NCT00565396 · start 2004-09

    Registered record
    Registry ID
    NCT00565396
    Conditions
    Chronic Kidney Insufficiency; Angiotensin-Converting Enzyme Inhibitors; Angiotensin II Type 1 Receptor Blockers; Proteinuria
    Interventions
    Fosinopril and Losartan
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2004-09
    Completion
    2008-07
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Insufficiency; Angiotensin-Converting Enzyme Inhibitors; Angiotensin II Type 1 Receptor Blockers; Proteinuria
    InterventionFosinopril and Losartan
    PhaseNot applicable
    Registry statusUnknown

  • Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension

    NCT00684489 · start 2003-09

    Registered record
    Registry ID
    NCT00684489
    Conditions
    Hypertension
    Interventions
    clinical hypertension specialist-no specific med. Any anti-hypertension meds.; renin guided therapeutics-no specific med. Any anti-hypertensive med.
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-09
    Completion
    2005-09
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionclinical hypertension specialist-no specific med. Any anti-hypertension meds.; renin guided therapeutics-no specific med. Any anti-hypertensive med.
    PhaseNot applicable
    Registry statusCompleted