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AMR Drug RepurposingSmart Screeningresearch prototype

Lypressin

FDA-approved product (solution, nasal), marketed as Diapid.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Lypressin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Lypressin. Its therapeutic class is shown instead.

WHO therapeutic group
Vasopressin and analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA63.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae48.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis59.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lypressin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lypressin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effects of Terlipressin on Blood Loss and Transfusion Requirements During Major Liver Resection.

    NCT02588716 · start 2015-09

    Registered record
    Registry ID
    NCT02588716
    Conditions
    Hepatectomy, Surgical Blood Loss, Terlipressin
    Interventions
    Terlipressin; normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-09
    Completion
    2016-12
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatectomy, Surgical Blood Loss, Terlipressin
    InterventionTerlipressin; normal saline
    PhasePhase 2
    Registry statusCompleted

  • The Effect of Terlipressin in the Prevention of Type 2 Hepatorenal Syndrome by Improving Mean Arterial Pressure

    NCT02489864 · start 2015-07

    Registered record
    Registry ID
    NCT02489864
    Conditions
    Hepatorenal Syndrome
    Interventions
    Terlipressin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-07
    Completion
    2017-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatorenal Syndrome
    InterventionTerlipressin
    PhasePhase 4
    Registry statusUnknown

  • The Effect of Terlipressin on Intesitnal Function in Septic Shock Patients

    NCT02306239 · start 2014-12

    Registered record
    Registry ID
    NCT02306239
    Conditions
    Terlipressin; Septic Shock
    Interventions
    Terlipressin; Norepinephrine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2014-12
    Completion
    Not recorded
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTerlipressin; Septic Shock
    InterventionTerlipressin; Norepinephrine
    PhaseNot applicable
    Registry statusUnknown

  • Hemodynamic Effects of Terlipressin and High Dose Octreotide

    NCT02119884 · start 2014-02

    Registered record
    Registry ID
    NCT02119884
    Conditions
    Gastric and Esophageal Varices
    Interventions
    Terlipressin; Octreotide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-02
    Completion
    2016-06
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastric and Esophageal Varices
    InterventionTerlipressin; Octreotide
    PhasePhase 4
    Registry statusCompleted

  • Effects of Terlipressin When Usual Somatostatin or Octreotide Dose Fails

    NCT02311608 · start 2014-02

    Registered record
    Registry ID
    NCT02311608
    Conditions
    Liver Cirrhosis; Esophageal and Gastric Varices; Hemorrhage
    Interventions
    Terlipressin; Usual Dose Somatostatin/Octreotide; High Dose Somatostatin/Octreotide
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2014-02
    Completion
    2016-06
    Enrolment
    1,320

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Cirrhosis; Esophageal and Gastric Varices; Hemorrhage
    InterventionTerlipressin; Usual Dose Somatostatin/Octreotide; High Dose Somatostatin/Octreotide
    PhaseNot recorded
    Registry statusUnknown

  • An Exploratory Haemodynamic Study in Patients With Compensated Cirrhosis and Portal Hypertension

    NCT01640964 · start 2013-04

    Registered record
    Registry ID
    NCT01640964
    Conditions
    Compensated Cirrhosis and Portal Hypertension
    Interventions
    Terlipressin acetate; Serelaxin (RLX030)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-04
    Completion
    2014-12
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCompensated Cirrhosis and Portal Hypertension
    InterventionTerlipressin acetate; Serelaxin (RLX030)
    PhasePhase 2
    Registry statusCompleted

  • Continuos Terlipressin Infusion in Septic Shock

    NCT01697410 · start 2013-01

    Registered record
    Registry ID
    NCT01697410
    Conditions
    Septic Shock
    Interventions
    Terlipressin; Norepinephrine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2013-01
    Completion
    2016-01
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeptic Shock
    InterventionTerlipressin; Norepinephrine
    PhaseNot applicable
    Registry statusUnknown

  • To Compare the Efficacy of Nor Adrenaline and Terlipressin vs Step up Terlipressin Therapy in Hepatorenal Syndrome

    NCT01649037 · start 2012-08

    Registered record
    Registry ID
    NCT01649037
    Conditions
    Hepatorenal Syndrome
    Interventions
    nor adrenaline and terlipressin; step up terlipressin therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2012-08
    Completion
    2015-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatorenal Syndrome
    Interventionnor adrenaline and terlipressin; step up terlipressin therapy
    PhaseNot applicable
    Registry statusWithdrawn

  • Treatment of Hepatorenal Syndrome With Terlipressin Infusion Adjusted to Hemodynamic Response

    NCT01530711 · start 2012-04

    Registered record
    Registry ID
    NCT01530711
    Conditions
    Cirrhosis; Hepatorenal Syndrome Type I
    Interventions
    Terlipressin and albumin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-04
    Completion
    2016-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCirrhosis; Hepatorenal Syndrome Type I
    InterventionTerlipressin and albumin
    PhasePhase 4
    Registry statusUnknown

  • Follow-up of Glypressin (Terlipressin) Clinical Efficacy in the Treatment of Bleeding Oesophageal Varices

    NCT01335516 · start 2010-11

    Registered record
    Registry ID
    NCT01335516
    Conditions
    Gastrointestinal Bleeding; Oesophageal Varices
    Interventions
    Glypressin (terlipressin)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-11
    Completion
    2011-08
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastrointestinal Bleeding; Oesophageal Varices
    InterventionGlypressin (terlipressin)
    PhaseNot recorded
    Registry statusCompleted

  • A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin

    NCT01143246 · start 2010-10-11

    Registered record
    Registry ID
    NCT01143246
    Conditions
    Hepatorenal Syndrome
    Interventions
    Terlipressin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-10-11
    Completion
    2013-05-10
    Enrolment
    196

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatorenal Syndrome
    InterventionTerlipressin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Vasoactive Drugs in Real World Practice

    NCT02757703 · start 2010-05

    Registered record
    Registry ID
    NCT02757703
    Conditions
    Vasoconstrictor Choice on Acute Variceal Bleeding
    Interventions
    Somatostatin; Terlipressin; Pantoprazole; Endoscopic variceal ligation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-05
    Completion
    2015-01
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVasoconstrictor Choice on Acute Variceal Bleeding
    InterventionSomatostatin; Terlipressin; Pantoprazole; Endoscopic variceal ligation
    PhasePhase 4
    Registry statusCompleted

  • A Study of Terlipressin in Patients With Hepatorenal Syndrome Type 1

    NCT01373606 · start 2007-11

    Registered record
    Registry ID
    NCT01373606
    Conditions
    Hepatorenal Syndrome Type 1
    Interventions
    Terlipressin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2007-11
    Completion
    2009-12
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatorenal Syndrome Type 1
    InterventionTerlipressin
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Continuous Infusion of Terlipressin in Septic Shock

    NCT00481572 · start 2007-01

    Registered record
    Registry ID
    NCT00481572
    Conditions
    Septic Shock
    Interventions
    Terlipressin; Vasopressin; Norepinephrine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-01
    Completion
    2007-12
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeptic Shock
    InterventionTerlipressin; Vasopressin; Norepinephrine
    PhasePhase 2
    Registry statusCompleted

  • Prevention of Esophageal Variceal Rebleeding

    NCT00863837 · start 2006-12

    Registered record
    Registry ID
    NCT00863837
    Conditions
    Esophageal Variceal Rebleeding
    Interventions
    terlipressin (vasoconstrictor); pantoloc (proton pump inhibitor)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2006-12
    Completion
    2009-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEsophageal Variceal Rebleeding
    Interventionterlipressin (vasoconstrictor); pantoloc (proton pump inhibitor)
    PhasePhase 4
    Registry statusUnknown