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AMR Drug RepurposingSmart Screeningresearch prototype

Sildenafil Citrate

FDA-approved product (tablet, oral), marketed as Liqrev, Revatio, Sildenafil Citrate and 2 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Sildenafil Citrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Connective tissue disease
  • Erectile dysfunction
  • Idiopathic and/or familial pulmonary arterial hypertension
  • Impotence
  • Pulmonary arterial hypertension
  • Pulmonary hypertension

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Drugs used in erectile dysfunction
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli42.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae39.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sildenafil Citrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sildenafil Citrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Does Sildenafil Increase Exercise Performance in Air Pollution?

    NCT00808912 · start 2008-12

    Registered record
    Registry ID
    NCT00808912
    Conditions
    Pulmonary Hypertension; Pulmonary Artery Pressure; Exercise Performance; Air Pollution
    Interventions
    sildenafil; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-12
    Completion
    2010-02
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Hypertension; Pulmonary Artery Pressure; Exercise Performance; Air Pollution
    Interventionsildenafil; placebo
    PhaseNot applicable
    Registry statusCompleted

  • Sildenafil IV Bolus Study

    NCT00800592 · start 2008-10

    Registered record
    Registry ID
    NCT00800592
    Conditions
    Hypertension, Pulmonary
    Interventions
    sildenafil
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-10
    Completion
    2008-12
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension, Pulmonary
    Interventionsildenafil
    PhasePhase 1
    Registry statusCompleted

  • A Randomized, Double-Blinded, Placebo-Controlled, Two-Way Crossover Study to Investigate the Safety and Toleration of Single Dose Sildenafil in Subjects Receiving Chronic UK-369,0031

    NCT00814736 · start 2008-08

    Registered record
    Registry ID
    NCT00814736
    Conditions
    Prostatic Hyperplasia; Urinary Bladder, Overactive; Erectile Dysfunction
    Interventions
    UK369,003; sildenafil; sildenafil matching placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-08
    Completion
    2008-09
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstatic Hyperplasia; Urinary Bladder, Overactive; Erectile Dysfunction
    InterventionUK369,003; sildenafil; sildenafil matching placebo
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetics and Pharmacdynamics of Sildenafil

    NCT00718185 · start 2008-05

    Registered record
    Registry ID
    NCT00718185
    Conditions
    Pulmonary Hypertension
    Interventions
    Obtain blood specimens
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2008-05
    Completion
    2010-02
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Hypertension
    InterventionObtain blood specimens
    PhaseNot recorded
    Registry statusTerminated

  • Modulating Effects of Lisinopril on Sildenafil Activity in Pulmonary Arterial Hypertension(PAH)( MELISSA)

    NCT01181284 · start 2008-05

    Registered record
    Registry ID
    NCT01181284
    Conditions
    Pulmonary Arterial Hypertension
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-05
    Completion
    2011-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Arterial Hypertension
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • The Effect of CYP3A Genetic Polymorphism on the Pharmacokinetics of Phosphodiesterase type5 Inhibitors in Male Subjects

    NCT00767598 · start 2007-12

    Registered record
    Registry ID
    NCT00767598
    Conditions
    Pharmacokinetics of Three PDE5Is; Healthy Subjects; Genetic Polymorphic CYP3A5
    Interventions
    phosphodiesterase type 5 inhibitor; phosphodiesterase type 5 inhibitor; phosphodiesterase type 5 inhibitor
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-12
    Completion
    2008-07
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharmacokinetics of Three PDE5Is; Healthy Subjects; Genetic Polymorphic CYP3A5
    Interventionphosphodiesterase type 5 inhibitor; phosphodiesterase type 5 inhibitor; phosphodiesterase type 5 inhibitor
    PhasePhase 1
    Registry statusCompleted

  • COMPERA / COMPERA-KIDS

    NCT01347216 · start 2007-07-01

    Registered record
    Registry ID
    NCT01347216
    Conditions
    Pulmonary Arterial Hypertension (PAH); Pulmonary Hypertension (PH)
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2007-07-01
    Completion
    2026-12-31
    Enrolment
    14,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Arterial Hypertension (PAH); Pulmonary Hypertension (PH)
    InterventionNot recorded
    PhaseNot recorded
    Registry statusRecruiting

  • Combination Therapy in Pulmonary Arterial Hypertension

    NCT00433329 · start 2007-03

    Registered record
    Registry ID
    NCT00433329
    Conditions
    Pulmonary Arterial Hypertension
    Interventions
    Bosentan; Sildenafil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-03
    Completion
    2010-08
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Arterial Hypertension
    InterventionBosentan; Sildenafil
    PhasePhase 4
    Registry statusCompleted

  • Viagra for the Treatment of IUGR

    NCT00347867 · start 2006-07

    Registered record
    Registry ID
    NCT00347867
    Conditions
    IUGR
    Interventions
    Viagra administration in IUGR/PET pregnancies
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2006-07
    Completion
    Not recorded
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIUGR
    InterventionViagra administration in IUGR/PET pregnancies
    PhasePhase 4
    Registry statusUnknown

  • Chronic Sildenafil for Severe Diaphragmatic Hernia

    NCT00133679 · start 2006-02

    Registered record
    Registry ID
    NCT00133679
    Conditions
    Hernia, Diaphragmatic; Hypertension, Pulmonary; Hypoplasia, Pulmonary
    Interventions
    sildenafil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2006-02
    Completion
    2013-10
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHernia, Diaphragmatic; Hypertension, Pulmonary; Hypoplasia, Pulmonary
    Interventionsildenafil; Placebo
    PhasePhase 4
    Registry statusTerminated

  • Quality of Erection Study

    NCT00159900 · start 2005-05

    Registered record
    Registry ID
    NCT00159900
    Conditions
    Erectile Dysfunction
    Interventions
    Sildenafil Citrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-05
    Completion
    2006-01
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErectile Dysfunction
    InterventionSildenafil Citrate
    PhasePhase 4
    Registry statusCompleted

  • An Open Label, Dose Finding Trial of Viagra for the Treatment of Neuropathic Pain (in Diabetes Mellitus)

    NCT00194909 · start 2004-08

    Registered record
    Registry ID
    NCT00194909
    Conditions
    Diabetic Neuropathy
    Interventions
    sildenafil (Viagra)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-08
    Completion
    2006-07
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Neuropathy
    Interventionsildenafil (Viagra)
    PhasePhase 4
    Registry statusCompleted

  • Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III

    NCT00194597 · start 2004-07

    Registered record
    Registry ID
    NCT00194597
    Conditions
    Prostatitis
    Interventions
    Viagra (sildenafil citrate)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2004-07
    Completion
    2007-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstatitis
    InterventionViagra (sildenafil citrate)
    PhasePhase 4
    Registry statusTerminated

  • Sildenafil for Treatment of Digital Ulcers in Patients With Systemic Sclerosis

    NCT00624273 · start 2004-02

    Registered record
    Registry ID
    NCT00624273
    Conditions
    Active Digital Ulcers
    Interventions
    Sildenafil therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-02
    Completion
    2007-02
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActive Digital Ulcers
    InterventionSildenafil therapy
    PhasePhase 2
    Registry statusCompleted

  • A Long Term Extension Study Evaluating Safety Of Sildenafil Citrate When Used To Treat Pulmonary Arterial Hypertension (PAH) In Children

    NCT00159874 · start 2004-01

    Registered record
    Registry ID
    NCT00159874
    Conditions
    Pulmonary Arterial Hypertension
    Interventions
    Sildenafil citrate; Sildenafil citrate; Sildenafil citrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-01
    Completion
    2012-12
    Enrolment
    234

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Arterial Hypertension
    InterventionSildenafil citrate; Sildenafil citrate; Sildenafil citrate
    PhasePhase 3
    Registry statusCompleted