Cyclothiazide
FDA-approved product (tablet, oral), marketed as Anhydron, Fluidil.
- Registered studies
- 0
- Lab records
- 0
- Pathogens at ≥40%
- 2 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Cardiovascular disease
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Thiazides, plain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA42.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli33.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae20.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Cyclothiazide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- EverolimusExisting use: Adenoma sebaceum, Anaplastic astrocytoma, Angiomyolipoma and 18 more53.9% AI-predicted activityagainst E. coli50+ registered studies
- UbrogepantExisting use: Migraine disorder53.8% AI-predicted activityagainst E. coli24 registered studies
- Caspofungin AcetateExisting use: Aspergillosis, Candidemia, Candidiasis and 1 more53.7% AI-predicted activityagainst E. coli50+ registered studies
- OdevixibatExisting use: Intrahepatic cholestasis53.7% AI-predicted activityagainst E. coli13 registered studies
- PosaconazoleExisting use: Aspergillosis, Candidiasis, Coccidioidomycosis and 2 more53.6% AI-predicted activityagainst E. coli50+ registered studies
- SiponimodExisting use: Multiple sclerosis53.6% AI-predicted activityagainst E. coli33 registered studies
- LonafarnibExisting use: Hutchinson-Gilford progeria syndrome, Laminopathies, Progeria53.6% AI-predicted activityagainst E. coli39 registered studies
- Brilliant Blue GExisting use: Disclosing Agent53.4% AI-predicted activityagainst E. coli10 registered studies
- AbarelixExisting use: Neoplasm53.4% AI-predicted activityagainst E. coli5 registered studies
- CyclosporineExisting use: Conjunctivitis, Corneal disease, Eye disease and 6 more53.3% AI-predicted activityagainst E. coli50+ registered studies
- Simeprevir SodiumExisting use: Chronic hepatitis C virus infection53.2% AI-predicted activityagainst E. coliNo documented evidence found
- Ergotamine TartrateExisting use: Headache, Migraine disorder53.1% AI-predicted activityagainst E. coli10 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.