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AMR Drug RepurposingSmart Screeningresearch prototype

Penicillin V

FDA-approved product (for suspension, oral), marketed as V-Cillin, Beepen-Vk, Betapen-Vk and 12 more.

Registered studies
30
Lab records
10
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Penicillin V
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Arthritis
  • Bacterial disease
  • Bacterial endocarditis
  • Bacteriemia
  • Infection
  • Infectious meningitis
  • Scarlet fever

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta-lactamase sensitive penicillins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CE02; WHO ATC J01CE10

Repurposing investigation

Penicillin V is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA76.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli5.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae4.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis33.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

30registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 2 of 3 lab records
  • E. coli: measured active in 0 of 4 lab records
  • K. pneumoniae: measured active in 0 of 3 lab records
Open Penicillin V in ChEMBL Registered studies below
Show the 10 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Penicillin V with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children

    NCT07798232 · start 2027-02-01

    Registered record
    Registry ID
    NCT07798232
    Conditions
    Rheumatic Heart Disease in Children
    Interventions
    Oral Penicillin V
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2027-02-01
    Completion
    2032-03-01
    Enrolment
    9,622

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRheumatic Heart Disease in Children
    InterventionOral Penicillin V
    PhasePhase 3
    Registry statusNot yet recruiting

  • Prophylaxis of Recurrent Erysipelas in Lower Limbs: compreSsion thErapy vs aNTibiotics and Compression Therapy.

    NCT07549594 · start 2026-04-01

    Registered record
    Registry ID
    NCT07549594
    Conditions
    Recurrent Erysipelas
    Interventions
    elastic stockings; Phenoxymethylpenicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-04-01
    Completion
    2030-04-01
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecurrent Erysipelas
    Interventionelastic stockings; Phenoxymethylpenicillin
    PhasePhase 4
    Registry statusNot yet recruiting

  • The Optimal Antibiotic Treatment Duration for Community-acquired Pneumonia in Adults Diagnosed in General Practice in Denmark (CAP-D)

    NCT06295120 · start 2023-11-13

    Registered record
    Registry ID
    NCT06295120
    Conditions
    Community-acquired Pneumonia
    Interventions
    Phenoxymethylpenicillin 1.2 MIE 4 times daily
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2023-11-13
    Completion
    2026-03-31
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-acquired Pneumonia
    InterventionPhenoxymethylpenicillin 1.2 MIE 4 times daily
    PhasePhase 4
    Registry statusRecruiting

  • GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial

    NCT05693545 · start 2023-09-01

    Registered record
    Registry ID
    NCT05693545
    Conditions
    Rheumatic Heart Disease
    Interventions
    phenoxymethyl penicillin; intramuscular benzathine penicillin G (BPG) prophylaxis
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2023-09-01
    Completion
    2027-09-30
    Enrolment
    1,004

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRheumatic Heart Disease
    Interventionphenoxymethyl penicillin; intramuscular benzathine penicillin G (BPG) prophylaxis
    PhasePhase 2
    Registry statusActive not recruiting

  • Addition of Probenecid to Penicillin-V Therapy

    NCT05082909 · start 2021-12-21

    Registered record
    Registry ID
    NCT05082909
    Conditions
    Infection, Bacterial
    Interventions
    Probenecid
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2021-12-21
    Completion
    2022-07-07
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection, Bacterial
    InterventionProbenecid
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Effects of Phenoximethylpenicillin, Amoxicillin and Amoxicillin-clavulanic Acid on the Gut Microbiota

    NCT04084106 · start 2019-09-10

    Registered record
    Registry ID
    NCT04084106
    Conditions
    Infectious Disease
    Interventions
    Phenoxymethylpenicillin; Amoxicillin; Amoxicillin-clavulanic acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-09-10
    Completion
    2022-11-11
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfectious Disease
    InterventionPhenoxymethylpenicillin; Amoxicillin; Amoxicillin-clavulanic acid
    PhasePhase 4
    Registry statusCompleted

  • Sore Throat in Primary Care - a Comparison of Phenoxymethylpenicillin and No Antibiotic Treatment

    NCT04083417 · start 2019-09-09

    Registered record
    Registry ID
    NCT04083417
    Conditions
    Sore Throat; Tonsillitis
    Interventions
    Phenoxymethylpenicillin; No antibiotic treatment
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2019-09-09
    Completion
    2026-06
    Enrolment
    260

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSore Throat; Tonsillitis
    InterventionPhenoxymethylpenicillin; No antibiotic treatment
    PhasePhase 4
    Registry statusRecruiting

  • Minimally Invasive Sensing of Beta-lactam Antibiotics

    NCT03847610 · start 2018-04-12

    Registered record
    Registry ID
    NCT03847610
    Conditions
    Healthy Volunteers
    Interventions
    Phenoxymethyl Penicillin; Microneedle array
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2018-04-12
    Completion
    2018-08-10
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionPhenoxymethyl Penicillin; Microneedle array
    PhasePhase 1
    Registry statusCompleted

  • Peritonsillar Abscess: Aspiration Versus Tonsillectomy a Chaud

    NCT03326661 · start 2017-11-10

    Registered record
    Registry ID
    NCT03326661
    Conditions
    Peritonsillar Abscess
    Interventions
    Aspiration; Tonsillectomy a chaud; Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-11-10
    Completion
    2020-11-30
    Enrolment
    128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeritonsillar Abscess
    InterventionAspiration; Tonsillectomy a chaud; Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
    PhaseNot applicable
    Registry statusUnknown

  • Penicillin for the Emergency Department Outpatient Treatment of CELLulitis

    NCT02922686 · start 2016-12

    Registered record
    Registry ID
    NCT02922686
    Conditions
    Cellulitis; Wound Infection; Abscess
    Interventions
    Flucloxacillin; Phenoxymethylpenicillin; Placebo (for phenoxymethylpenicillin)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-12
    Completion
    2019-12
    Enrolment
    414

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCellulitis; Wound Infection; Abscess
    InterventionFlucloxacillin; Phenoxymethylpenicillin; Placebo (for phenoxymethylpenicillin)
    PhasePhase 4
    Registry statusUnknown

  • Zinc Supplementation in Children With Sickle Cell Disease in Western Kenya

    NCT03293641 · start 2016-05-20

    Registered record
    Registry ID
    NCT03293641
    Conditions
    Sickle Cell Disease; Zinc Deficiency; Infection
    Interventions
    Zinc Sulfate Tablets; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-05-20
    Completion
    2017-01-19
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSickle Cell Disease; Zinc Deficiency; Infection
    InterventionZinc Sulfate Tablets; Standard of Care
    PhaseNot applicable
    Registry statusCompleted

  • Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci

    NCT02712307 · start 2015-09

    Registered record
    Registry ID
    NCT02712307
    Conditions
    Tonsillitis
    Interventions
    Phenoxymethylpenicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-09
    Completion
    2018-06
    Enrolment
    433

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTonsillitis
    InterventionPhenoxymethylpenicillin
    PhasePhase 4
    Registry statusCompleted

  • Surgical Treatment of Peri-implantitis With and Without Systemically Adjunctive Antibiotics

    NCT02185209 · start 2015-03

    Registered record
    Registry ID
    NCT02185209
    Conditions
    Periodontal Diseases; Periimplantitis
    Interventions
    Placebo; Amoxicillin Sandoz; Metronidazole Sanofi; Phenoxymethylpenicillin Meda
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-03
    Completion
    2022-05-27
    Enrolment
    77

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontal Diseases; Periimplantitis
    InterventionPlacebo; Amoxicillin Sandoz; Metronidazole Sanofi; Phenoxymethylpenicillin Meda
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis

    NCT02168816 · start 2014-03-19

    Registered record
    Registry ID
    NCT02168816
    Conditions
    Osteomyelitis
    Interventions
    Intravenous Antibacterial Agent; Oral Antibacterial Agent
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2014-03-19
    Completion
    2017-02-02
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    InterventionIntravenous Antibacterial Agent; Oral Antibacterial Agent
    PhasePhase 2
    Registry statusTerminated

  • Patients Response to Early Switch To Oral:Osteomyelitis Study

    NCT02099240 · start 2014-03-06

    Registered record
    Registry ID
    NCT02099240
    Conditions
    Osteomyelitis
    Interventions
    oral antibiotics; intravenous antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2014-03-06
    Completion
    2018-11-07
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventionoral antibiotics; intravenous antibiotics
    PhaseEarly phase 1
    Registry statusTerminated