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AMR Drug RepurposingSmart Screeningresearch prototype

Penicillin V

FDA-approved product (for suspension, oral), marketed as V-Cillin, Beepen-Vk, Betapen-Vk and 12 more.

Registered studies
30
Lab records
10
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Penicillin V
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Arthritis
  • Bacterial disease
  • Bacterial endocarditis
  • Bacteriemia
  • Infection
  • Infectious meningitis
  • Scarlet fever

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta-lactamase sensitive penicillins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CE02; WHO ATC J01CE10

Repurposing investigation

Penicillin V is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA76.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli5.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae4.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis33.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

30registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 2 of 3 lab records
  • E. coli: measured active in 0 of 4 lab records
  • K. pneumoniae: measured active in 0 of 3 lab records
Open Penicillin V in ChEMBL Registered studies below
Show the 10 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Penicillin V with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of High Doses Penicillin V Versus High Doses Amoxicillin in the Treatment of Non-severe Pneumonia.

    NCT03208361 · start 2013-11-05

    Registered record
    Registry ID
    NCT03208361
    Conditions
    Community-acquired Pneumonia (CAP)
    Interventions
    Penicillin V; Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2013-11-05
    Completion
    2016-04-21
    Enrolment
    43

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-acquired Pneumonia (CAP)
    InterventionPenicillin V; Amoxicillin
    PhasePhase 3
    Registry statusTerminated

  • Influence of Medication Taste on Pediatric Prescribers' Prescribing Habits

    NCT01734759 · start 2012-11

    Registered record
    Registry ID
    NCT01734759
    Conditions
    Healthy
    Interventions
    Taste Test
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-11
    Completion
    2013-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTaste Test
    PhasePhase 1
    Registry statusCompleted

  • A Pharmacokinetic and Pharmacodynamic Study of Phenoxymethylpenicillin for Children

    NCT01499875 · start 2012-01

    Registered record
    Registry ID
    NCT01499875
    Conditions
    Phenoxymethylpenicillin
    Interventions
    Phenoxymethylpenicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-01
    Completion
    2013-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPhenoxymethylpenicillin
    InterventionPhenoxymethylpenicillin
    PhasePhase 1
    Registry statusCompleted

  • Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice

    NCT01368341 · start 2011-06

    Registered record
    Registry ID
    NCT01368341
    Conditions
    Erythema Migrans; Erythema Chronicum Migrans; Borreliosis; Lyme Disease; Early Lyme Disease
    Interventions
    Doxycycline; Phenoxymethylpenicillin; Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-06
    Completion
    2014-12
    Enrolment
    225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErythema Migrans; Erythema Chronicum Migrans; Borreliosis; Lyme Disease +1 more
    InterventionDoxycycline; Phenoxymethylpenicillin; Amoxicillin
    PhasePhase 4
    Registry statusCompleted

  • Pentriox - Induction of Oxidative Stress

    NCT02188472 · start 2010-11

    Registered record
    Registry ID
    NCT02188472
    Conditions
    Oxidative Stress
    Interventions
    Penicillin V; Trimethoprim; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-11
    Completion
    2011-02
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOxidative Stress
    InterventionPenicillin V; Trimethoprim; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Infant Severe Sepsis and Bacterial Meningitis in Malawi

    NCT01247909 · start 2010-04

    Registered record
    Registry ID
    NCT01247909
    Conditions
    Infant Bacterial Meningitis
    Interventions
    Ceftriaxone v penicillin and gentamicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-04
    Completion
    2015-04
    Enrolment
    351

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfant Bacterial Meningitis
    InterventionCeftriaxone v penicillin and gentamicin
    PhasePhase 4
    Registry statusCompleted

  • Inflammatory Response to Hydroxyurea Therapy in Sickle Cell Disease

    NCT00784082 · start 2009-05

    Registered record
    Registry ID
    NCT00784082
    Conditions
    Sickle Cell Disease
    Interventions
    Hydroxycarbamide, Hydroxyurea (drug)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-05
    Completion
    2012-11
    Enrolment
    62

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSickle Cell Disease
    InterventionHydroxycarbamide, Hydroxyurea (drug)
    PhaseNot recorded
    Registry statusCompleted

  • Oral Penicillin and Penicillin Levels in Venous Umbilical Cord Blood

    NCT00823433 · start 2009-01

    Registered record
    Registry ID
    NCT00823433
    Conditions
    Group B Streptococcus
    Interventions
    oral penicillin V
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2009-01
    Completion
    2009-12
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGroup B Streptococcus
    Interventionoral penicillin V
    PhaseEarly phase 1
    Registry statusTerminated

  • RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg

    NCT00552799 · start 2006-07

    Registered record
    Registry ID
    NCT00552799
    Conditions
    Cellulitis/Erysipelas of the Leg
    Interventions
    Penicillin VK; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-07
    Completion
    2011-11
    Enrolment
    274

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCellulitis/Erysipelas of the Leg
    InterventionPenicillin VK; placebo
    PhasePhase 4
    Registry statusCompleted

  • TELI TON - Telithromycin in Tonsillitis

    NCT00315042 · start 2006-03

    Registered record
    Registry ID
    NCT00315042
    Conditions
    Tonsillitis; Pharyngitis
    Interventions
    Telithromycin (HMR3647); Penicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2006-03
    Completion
    2006-08
    Enrolment
    314

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTonsillitis; Pharyngitis
    InterventionTelithromycin (HMR3647); Penicillin
    PhasePhase 3
    Registry statusTerminated

  • TELI TAD - Telithromycin in Tonsillitis in Adolescents and Adults

    NCT00315549 · start 2006-02

    Registered record
    Registry ID
    NCT00315549
    Conditions
    Tonsillitis; Pharyngitis
    Interventions
    Telithromycin; Penicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2006-02
    Completion
    2006-09
    Enrolment
    233

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTonsillitis; Pharyngitis
    InterventionTelithromycin; Penicillin
    PhasePhase 3
    Registry statusTerminated

  • APC-111 MP Tablet Once a Day vs.Penicillin VK Four Times a Day Both for 10 Days in Patients With Strep Throat

    NCT00242281 · start 2005-11

    Registered record
    Registry ID
    NCT00242281
    Conditions
    Sore Throat; Pharyngitis; Tonsillitis
    Interventions
    APC-111 MP Tablet, 775 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-11
    Completion
    2006-07
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSore Throat; Pharyngitis; Tonsillitis
    InterventionAPC-111 MP Tablet, 775 mg
    PhasePhase 3
    Registry statusCompleted

  • APC-231 Once a Day (QD) for 7 Days vs. Penicillin Taken Four Times a Day (QID) in Pediatric Patients With Strep Throat

    NCT00100126 · start 2004-12

    Registered record
    Registry ID
    NCT00100126
    Conditions
    Pharyngitis
    Interventions
    Amoxicillin Pulsatile Release Multiparticluate Sprinkle
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-12
    Completion
    2005-06
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharyngitis
    InterventionAmoxicillin Pulsatile Release Multiparticluate Sprinkle
    PhasePhase 3
    Registry statusCompleted

  • APC-111 Once a Day (QD) for 7 Days vs. Penicillin Taken Four Times a Day (QID) for 10 Days in Patients With Strep Throat

    NCT00095368 · start 2004-10

    Registered record
    Registry ID
    NCT00095368
    Conditions
    Pharyngitis; Tonsillitis
    Interventions
    Amoxicillin Pulsatile Release Multiparticulate Tablet (drug)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-10
    Completion
    2005-05
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharyngitis; Tonsillitis
    InterventionAmoxicillin Pulsatile Release Multiparticulate Tablet (drug)
    PhasePhase 3
    Registry statusCompleted

  • Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea

    NCT00615797 · start 2002-05

    Registered record
    Registry ID
    NCT00615797
    Conditions
    Sydenham Chorea; Post Streptococcal Movement Disorder
    Interventions
    Intravenous immunoglobulin; standard interventions penicillin VK and haloperidol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2002-05
    Completion
    2009-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSydenham Chorea; Post Streptococcal Movement Disorder
    InterventionIntravenous immunoglobulin; standard interventions penicillin VK and haloperidol
    PhaseNot applicable
    Registry statusCompleted