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AMR Drug RepurposingSmart Screeningresearch prototype

Rosuvastatin Calcium

FDA-approved product (tablet, oral), marketed as Crestor, Ezallor Sprinkle, Rosuvastatin Calcium.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Rosuvastatin Calcium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Atherosclerosis
  • Cardiovascular disease
  • Coronary artery disease
  • Familial hypercholesterolemia
  • Hypercholesterolemia
  • Hyperlipidemia
  • Hyperlipoproteinemia type 3

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Hmg coa reductase inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae24.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis63.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Rosuvastatin Calcium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Rosuvastatin Calcium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Phase 1 Clinical Trial to Investigate the Effect on the Pharmacokinetics of YH14755 Compared to Co-administration of Rosuvastatin and Metformin SR in Healthy Volunteers

    NCT02125227 · start 2014-04

    Registered record
    Registry ID
    NCT02125227
    Conditions
    Healthy
    Interventions
    Rosuvastatin, Metformin, YH14755; YH14755
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-04
    Completion
    2014-09
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionRosuvastatin, Metformin, YH14755; YH14755
    PhasePhase 1
    Registry statusCompleted

  • Efficacy and Safety of PRC-4016 in Subjects With Mixed Dyslipidemia

    NCT01972178 · start 2013-11

    Registered record
    Registry ID
    NCT01972178
    Conditions
    Dyslipidemia
    Interventions
    PRC-4016; Placebo; Statins
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2013-11
    Completion
    2014-08
    Enrolment
    113

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDyslipidemia
    InterventionPRC-4016; Placebo; Statins
    PhasePhase 2
    Registry statusTerminated

  • Efficacy/Safety of Rosuvastatin+Ezetimibe in High Risk Patients With Primary Hypercholesterolemia/Mixed Dyslipidemia

    NCT01420549 · start 2013-03

    Registered record
    Registry ID
    NCT01420549
    Conditions
    Hypercholesterolemia; Dyslipidemia
    Interventions
    Rosuvastatin 10 mg + Ezetimibe 10 mg and Rosuvastatin 20 mg + Ezetimibe 10 mg, according to clinical evaluation.; Simvastatin 20 mg + Ezetimibe 10 mg and Simvastatin 40 mg + Ezetimibe 10 mg, according to clinical evaluation.
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-03
    Completion
    2014-11
    Enrolment
    129

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia; Dyslipidemia
    InterventionRosuvastatin 10 mg + Ezetimibe 10 mg and Rosuvastatin 20 mg + Ezetimibe 10 mg, according to clinical evaluation.; Simvastatin 20 mg + Ezetimibe 10 mg and Simvastatin 40 mg + Ezetimibe 10 mg, according to clinical evaluation.
    PhasePhase 3
    Registry statusCompleted

  • Rosuvastatin Calcium Bioequivalence Study - Fast

    NCT01711749 · start 2013-02-25

    Registered record
    Registry ID
    NCT01711749
    Conditions
    Hypercholesterolaemia
    Interventions
    Crestor®; rosuvastatin calcium tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-02-25
    Completion
    2013-03-13
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolaemia
    InterventionCrestor®; rosuvastatin calcium tablets
    PhasePhase 1
    Registry statusCompleted

  • Clinical Study for Patients With Hypertension Associated With Dyslipidemia

    NCT01764295 · start 2012-09

    Registered record
    Registry ID
    NCT01764295
    Conditions
    Hypertension; Dyslipidemia
    Interventions
    DWJ1276; Olmesartan; Rosuvastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-09
    Completion
    2013-07
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Dyslipidemia
    InterventionDWJ1276; Olmesartan; Rosuvastatin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Statin for Depression in Patients Undergoing Coronary Artery Bypass Graft

    NCT01624857 · start 2012-06

    Registered record
    Registry ID
    NCT01624857
    Conditions
    Coronary Heart Disease
    Interventions
    Rosuvastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2012-06
    Completion
    2014-06
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Heart Disease
    InterventionRosuvastatin; Placebo
    PhasePhase 3
    Registry statusUnknown

  • Statin Therapy In Cardiac Surgery

    NCT01573143 · start 2011-09

    Registered record
    Registry ID
    NCT01573143
    Conditions
    Atrial Fibrillation; Myocardium; Injury
    Interventions
    Rosuvastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-09
    Completion
    2014-09
    Enrolment
    1,922

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Myocardium; Injury
    InterventionRosuvastatin; Placebo
    PhasePhase 4
    Registry statusCompleted

  • A Randomized Trial of Rosuvastatin in Elective Angioplasty to Prevent Contrast-induced Nephropathy (CLEAR-CIN).

    NCT02737319 · start 2011-03

    Registered record
    Registry ID
    NCT02737319
    Conditions
    Nephropathy
    Interventions
    Rosuvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-03
    Completion
    2013-12
    Enrolment
    493

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNephropathy
    InterventionRosuvastatin
    PhasePhase 4
    Registry statusCompleted

  • Use of Rosuvastatin in HIV-Infected Subjects to Modulate Cardiovascular Risks

    NCT01218802 · start 2011-02

    Registered record
    Registry ID
    NCT01218802
    Conditions
    HIV Infections; Heart Disease
    Interventions
    Rosuvastatin 10 mg. daily for 96 weeks; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-02
    Completion
    2014-05
    Enrolment
    147

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Heart Disease
    InterventionRosuvastatin 10 mg. daily for 96 weeks; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Effects of Rosuvastatin on the Immune System in Healthy Volunteers With Normal Cholesterol

    NCT01200836 · start 2010-07-01

    Registered record
    Registry ID
    NCT01200836
    Conditions
    Healthy Volunteers; Statins; Immune Modulation
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-07-01
    Completion
    2018-10-04
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers; Statins; Immune Modulation
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • The Endothelium Dysfunction in Patients of Obstructive Sleep Apnea Syndrome

    NCT01699126 · start 2010-05

    Registered record
    Registry ID
    NCT01699126
    Conditions
    Sleep Apnea, Obstructive
    Interventions
    CPAP; Statin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-05
    Completion
    2013-08
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSleep Apnea, Obstructive
    InterventionCPAP; Statin
    PhasePhase 4
    Registry statusCompleted

  • Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin

    NCT01146483 · start 2010-04

    Registered record
    Registry ID
    NCT01146483
    Conditions
    Drug Interaction Potentiation
    Interventions
    Rosuvastatin, Pantoprazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-04
    Completion
    2011-12
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Interaction Potentiation
    InterventionRosuvastatin, Pantoprazole
    PhasePhase 1
    Registry statusCompleted

  • Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery

    NCT01011478 · start 2010-03

    Registered record
    Registry ID
    NCT01011478
    Conditions
    Colorectal Cancer; Precancerous Condition
    Interventions
    rosuvastatin; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2010-03
    Completion
    2015-02
    Enrolment
    406

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer; Precancerous Condition
    Interventionrosuvastatin; placebo
    PhasePhase 3
    Registry statusTerminated

  • Bio Equivalence Study of Torrent Pharmaceutical Ltd's Rosuvastatin Calcium Tablets Under Fasting Condition.

    NCT02962310 · start 2009-10

    Registered record
    Registry ID
    NCT02962310
    Conditions
    Healthy Subjects
    Interventions
    Torrent's Rosuvastatin Calcium Tablets 40 mg; Crestor 40 mg Tablets of AstraZeneca LP, USA
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-10
    Completion
    2009-11
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Subjects
    InterventionTorrent's Rosuvastatin Calcium Tablets 40 mg; Crestor 40 mg Tablets of AstraZeneca LP, USA
    PhasePhase 1
    Registry statusCompleted

  • Tolerability and Lipid Lowering Effect of Weekly/Biweekly Crestor in Statin Intolerant Patients Treated With Zetia

    NCT00972829 · start 2009-09

    Registered record
    Registry ID
    NCT00972829
    Conditions
    Hypercholesterolemia
    Interventions
    Rosuvastatin; Ezetimibe
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2009-09
    Completion
    2011-03
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    InterventionRosuvastatin; Ezetimibe
    PhasePhase 4
    Registry statusUnknown