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AMR Drug RepurposingSmart Screeningresearch prototype

Oxycodone

FDA-approved product (capsule, extended release, oral), marketed as Xtampza Er, Oxaydo, Oxycodone Hydrochloride and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Oxycodone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Chronic pain
  • Drug dependence
  • Pain
  • Substance abuse

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Natural opium alkaloids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA42.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae44.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis42.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Oxycodone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Oxycodone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome

    NCT04134442 · start 2019-12-09

    Registered record
    Registry ID
    NCT04134442
    Conditions
    Osteoarthritis of the Shoulder; Shoulder Pain; Pain, Postoperative
    Interventions
    Bupivacaine Liposome Injection; Standard Therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2019-12-09
    Completion
    2021-09-23
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis of the Shoulder; Shoulder Pain; Pain, Postoperative
    InterventionBupivacaine Liposome Injection; Standard Therapy
    PhasePhase 4
    Registry statusWithdrawn

  • Narcotic Versus Non-narcotic Medication for Pain Management After Wrist/Hand Fractures

    NCT03375593 · start 2019-08-01

    Registered record
    Registry ID
    NCT03375593
    Conditions
    Distal Radius Fracture; Pain Management; Metacarpal Fracture
    Interventions
    Hydrocodone 5Mg/Acetaminophen 500Mg Tab; Acetaminophen 500Mg Tab; Ibuprofen 600 mg tab
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-08-01
    Completion
    2022-10-01
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDistal Radius Fracture; Pain Management; Metacarpal Fracture
    InterventionHydrocodone 5Mg/Acetaminophen 500Mg Tab; Acetaminophen 500Mg Tab; Ibuprofen 600 mg tab
    PhasePhase 4
    Registry statusUnknown

  • Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo.

    NCT03996694 · start 2019-07-23

    Registered record
    Registry ID
    NCT03996694
    Conditions
    Respiratory Depression
    Interventions
    Belbuca 300 µg; Belbuca 600 µg; Belbuca 900 µg; Oxycodone 30 mg; Oxycodone 60 mg; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-07-23
    Completion
    2019-10-27
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Depression
    InterventionBelbuca 300 µg; Belbuca 600 µg; Belbuca 900 µg; Oxycodone 30 mg +2 more
    PhasePhase 1
    Registry statusCompleted

  • Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial

    NCT03978767 · start 2019-06-10

    Registered record
    Registry ID
    NCT03978767
    Conditions
    Preeclampsia Severe; Preeclampsia Postpartum
    Interventions
    Ibuprofen 600 mg; Ketorolac; Acetaminophen; Oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2019-06-10
    Completion
    2026-06-15
    Enrolment
    287

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreeclampsia Severe; Preeclampsia Postpartum
    InterventionIbuprofen 600 mg; Ketorolac; Acetaminophen; Oxycodone
    PhasePhase 2
    Registry statusCompleted

  • Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery

    NCT04246541 · start 2019-04-23

    Registered record
    Registry ID
    NCT04246541
    Conditions
    Meniscus Tear, Tibial; Pain, Postoperative; Postoperative Complications; Ketorolac Adverse Reaction; Opioid Use
    Interventions
    Ketorolac; Oxycodone-Acetaminophen
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2019-04-23
    Completion
    2021-09-12
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMeniscus Tear, Tibial; Pain, Postoperative; Postoperative Complications; Ketorolac Adverse Reaction +1 more
    InterventionKetorolac; Oxycodone-Acetaminophen
    PhasePhase 3
    Registry statusCompleted

  • Supracondylar Humerus Fracture (SCHF) Post-Op Study Between Opioid and Non-Opioid Pain Management

    NCT06187584 · start 2019-04-15

    Registered record
    Registry ID
    NCT06187584
    Conditions
    Supracondylar Humerus Fracture
    Interventions
    Hydrocodone/acetaminophen; Acetaminophen; Ibuprofen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-04-15
    Completion
    2023-12-20
    Enrolment
    137

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSupracondylar Humerus Fracture
    InterventionHydrocodone/acetaminophen; Acetaminophen; Ibuprofen
    PhasePhase 4
    Registry statusCompleted

  • Effects of Duloxetine on Postoperative Wound Complication of Total Knee Arthroplasty (TKA) in Central Sensitization Patients

    NCT03880916 · start 2019-03-30

    Registered record
    Registry ID
    NCT03880916
    Conditions
    Osteoarthritis, Knee
    Interventions
    Duloxetine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2019-03-30
    Completion
    2020-03-31
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Knee
    InterventionDuloxetine; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Supracondylar Post-Operative Pain Study

    NCT03759028 · start 2019-02-26

    Registered record
    Registry ID
    NCT03759028
    Conditions
    Supracondylar Humerus Fracture
    Interventions
    Ibuprofen; Oxycodone; Acetaminophen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2019-02-26
    Completion
    2027-12-20
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSupracondylar Humerus Fracture
    InterventionIbuprofen; Oxycodone; Acetaminophen
    PhasePhase 4
    Registry statusRecruiting

  • MAST Trial: Multi-modal Analgesic Strategies in Trauma

    NCT03472469 · start 2018-04-02

    Registered record
    Registry ID
    NCT03472469
    Conditions
    Nonspecific Pain Post Traumatic Injury
    Interventions
    Acetaminophen IV/PO; Acetaminophen PO; Ketorolac; Celebrex; Naproxen; Tramadol; Pregabalin; Gabapentin; Lidocaine; Opioids; Regional anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-04-02
    Completion
    2019-07-03
    Enrolment
    1,561

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNonspecific Pain Post Traumatic Injury
    InterventionAcetaminophen IV/PO; Acetaminophen PO; Ketorolac; Celebrex +7 more
    PhasePhase 4
    Registry statusCompleted

  • Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section

    NCT03372382 · start 2017-12-13

    Registered record
    Registry ID
    NCT03372382
    Conditions
    Opioid Use; Pain, Postoperative
    Interventions
    Ibuprofen; Acetaminophen; Norco
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-12-13
    Completion
    2018-04-10
    Enrolment
    170

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Use; Pain, Postoperative
    InterventionIbuprofen; Acetaminophen; Norco
    PhasePhase 4
    Registry statusCompleted

  • Sleep/Wake Protocol Implementation to Improve Sleep Quality in the ICU

    NCT03313115 · start 2017-10-11

    Registered record
    Registry ID
    NCT03313115
    Conditions
    Sleep Deprivation; Delirium
    Interventions
    Sleep/Wake Protocol
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-10-11
    Completion
    2018-03-14
    Enrolment
    685

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSleep Deprivation; Delirium
    InterventionSleep/Wake Protocol
    PhaseNot recorded
    Registry statusCompleted

  • Sufentanil Sublingual Tablet System for Postoperative Pain Management After Total Knee Arthroplasty

    NCT04448457 · start 2017-09-01

    Registered record
    Registry ID
    NCT04448457
    Conditions
    Postoperative Pain
    Interventions
    Sufentanil Sublingual Tablet; Oxycodone oral tablet and oxycodone extended-release oral tablet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-09-01
    Completion
    2018-07-31
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionSufentanil Sublingual Tablet; Oxycodone oral tablet and oxycodone extended-release oral tablet
    PhaseNot applicable
    Registry statusCompleted

  • Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone

    NCT04399122 · start 2017-03-21

    Registered record
    Registry ID
    NCT04399122
    Conditions
    Post-operative Pain Control
    Interventions
    acetaminophen/codeine vs acetaminophen/oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-03-21
    Completion
    2019-10-28
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-operative Pain Control
    Interventionacetaminophen/codeine vs acetaminophen/oxycodone
    PhasePhase 4
    Registry statusCompleted

  • Population Pharmacokinetic-Pharmacodynamic Study of Intravenous Oxycodone in Malaysian Population

    NCT02728648 · start 2016-04

    Registered record
    Registry ID
    NCT02728648
    Conditions
    Pain
    Interventions
    Oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-04
    Completion
    2017-11
    Enrolment
    33

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionOxycodone
    PhasePhase 4
    Registry statusCompleted

  • Oxycodone in Serum After Postoperative Oral Oxycodone in Caesarean Sections Under Spinal Anesthesia

    NCT02717637 · start 2016-02

    Registered record
    Registry ID
    NCT02717637
    Conditions
    Analgesic Adverse Reaction; Cesarean Delivery Affecting Newborn
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-02
    Completion
    2017-04
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnalgesic Adverse Reaction; Cesarean Delivery Affecting Newborn
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted