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AMR Drug RepurposingSmart Screeningresearch prototype

Oxycodone

FDA-approved product (capsule, extended release, oral), marketed as Xtampza Er, Oxaydo, Oxycodone Hydrochloride and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Oxycodone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Chronic pain
  • Drug dependence
  • Pain
  • Substance abuse

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Natural opium alkaloids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA42.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae44.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis42.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Oxycodone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Oxycodone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Post-Vasectomy Pain RCT

    NCT07824258 · start 2026-09-10

    Registered record
    Registry ID
    NCT07824258
    Conditions
    Vasectomy; NSAIDs; Post-operative Care
    Interventions
    Acetaminophen; ibuprofen; oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Recruiting
    Start
    2026-09-10
    Completion
    2035-12-31
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVasectomy; NSAIDs; Post-operative Care
    InterventionAcetaminophen; ibuprofen; oxycodone
    PhasePhase 1
    Registry statusRecruiting

  • Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Orthopedic Surgery

    NCT07699601 · start 2026-05-09

    Registered record
    Registry ID
    NCT07699601
    Conditions
    Postoperative Pain
    Interventions
    HL-1186; HL-1186 placebo; Oxycodone-Acetaminophen; Oxycodone-Acetaminophen Matching Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Recruiting
    Start
    2026-05-09
    Completion
    2026-12
    Enrolment
    330

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionHL-1186; HL-1186 placebo; Oxycodone-Acetaminophen; Oxycodone-Acetaminophen Matching Placebo
    PhasePhase 2 / Phase 3
    Registry statusRecruiting

  • The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery

    NCT07432711 · start 2026-03-02

    Registered record
    Registry ID
    NCT07432711
    Conditions
    Video-assisted Thoracoscopic Surgery (VATS); Pain Management; Liposomal Bupivacaine; Local Injection
    Interventions
    Bupivacaine hydrochloride; Liposomal bupivacaine plus bupivacaine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-03-02
    Completion
    2027-06-30
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVideo-assisted Thoracoscopic Surgery (VATS); Pain Management; Liposomal Bupivacaine; Local Injection
    InterventionBupivacaine hydrochloride; Liposomal bupivacaine plus bupivacaine
    PhaseNot applicable
    Registry statusRecruiting

  • Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty

    NCT07219888 · start 2026-02-09

    Registered record
    Registry ID
    NCT07219888
    Conditions
    Osteoarthritis (OA) of the Knee
    Interventions
    oral suzetrigine; oral Oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Enrolling by invitation
    Start
    2026-02-09
    Completion
    2027-04-30
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis (OA) of the Knee
    Interventionoral suzetrigine; oral Oxycodone
    PhasePhase 4
    Registry statusEnrolling by invitation

  • Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia

    NCT07017452 · start 2025-08

    Registered record
    Registry ID
    NCT07017452
    Conditions
    Benign Prostate Hypertrophy(BPH)
    Interventions
    Methoxyflurane - Penthrox; Control; Percocet Pill; Lorazepam (drug)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2025-08
    Completion
    2026-06
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostate Hypertrophy(BPH)
    InterventionMethoxyflurane - Penthrox; Control; Percocet Pill; Lorazepam (drug)
    PhasePhase 3
    Registry statusNot yet recruiting

  • Sequential Method Determination of Oxycodone for Thoracoscope Surgery Median Effective Dose of Acute Pain Treatment

    NCT06534801 · start 2024-09-01

    Registered record
    Registry ID
    NCT06534801
    Conditions
    Oxycodone; Thoracoscopic Lobectomy; Acute Postoperative Pain
    Interventions
    Oxycodone will be administered intravenously in the group 1
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-09-01
    Completion
    2026-04-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOxycodone; Thoracoscopic Lobectomy; Acute Postoperative Pain
    InterventionOxycodone will be administered intravenously in the group 1
    PhaseNot applicable
    Registry statusUnknown

  • Effect of TEAS Combined With Oxycodone on Postoperative Visceral Pain in Gynecologic Laparoscopic Patients

    NCT06517069 · start 2024-05-01

    Registered record
    Registry ID
    NCT06517069
    Conditions
    Visceral Pain
    Interventions
    TEAS; Oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-05-01
    Completion
    2025-07-01
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVisceral Pain
    InterventionTEAS; Oxycodone
    PhaseNot applicable
    Registry statusUnknown

  • Assessment of PF614 Effects on Experimental Pain in the Cold Pressure Test (PF614-201)

    NCT06629402 · start 2023-10-05

    Registered record
    Registry ID
    NCT06629402
    Conditions
    Acute Pain
    Interventions
    PF614; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2023-10-05
    Completion
    2023-11-15
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain
    InterventionPF614; Placebo
    PhasePhase 2
    Registry statusCompleted

  • TAP Block Versus Conventional Systemic Analgesia

    NCT06058715 · start 2023-09-15

    Registered record
    Registry ID
    NCT06058715
    Conditions
    Analgesia
    Interventions
    Transverse Abdominal Plan block (TAP block)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-09-15
    Completion
    2024-10
    Enrolment
    380

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnalgesia
    InterventionTransverse Abdominal Plan block (TAP block)
    PhaseNot applicable
    Registry statusUnknown

  • Narcotic-Free Percutaneous Nephrolithotomy

    NCT05924165 · start 2023-05-19

    Registered record
    Registry ID
    NCT05924165
    Conditions
    Nephrolithiasis
    Interventions
    5mg Oxycodone, Q6 PRN; 10mg Ketorolac, Q6 PRN
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-05-19
    Completion
    2025-01-07
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNephrolithiasis
    Intervention5mg Oxycodone, Q6 PRN; 10mg Ketorolac, Q6 PRN
    PhasePhase 4
    Registry statusCompleted

  • A Study to Evaluate the Oral Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users (PF614-104)

    NCT05571345 · start 2022-10-05

    Registered record
    Registry ID
    NCT05571345
    Conditions
    Recreational Drug Use
    Interventions
    PF614; Oxycodone Hydrochloride 40 mg; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2022-10-05
    Completion
    2022-12-28
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecreational Drug Use
    InterventionPF614; Oxycodone Hydrochloride 40 mg; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms

    NCT05142267 · start 2022-03-02

    Registered record
    Registry ID
    NCT05142267
    Conditions
    Opioid Use Disorder; Back Pain; Stress
    Interventions
    Placebo; Oxycodone; Naloxone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-03-02
    Completion
    2026-04-07
    Enrolment
    101

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Use Disorder; Back Pain; Stress
    InterventionPlacebo; Oxycodone; Naloxone
    PhasePhase 4
    Registry statusCompleted

  • Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction

    NCT05161221 · start 2021-12-06

    Registered record
    Registry ID
    NCT05161221
    Conditions
    Pain, Postoperative; ACL
    Interventions
    OxyCODONE 5 mg Oral Tablet; Naproxen 500 Mg; Tylenol Pill; Liposomal bupivacaine; Femoral Nerve Catheter
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2021-12-06
    Completion
    2022-12-31
    Enrolment
    154

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative; ACL
    InterventionOxyCODONE 5 mg Oral Tablet; Naproxen 500 Mg; Tylenol Pill; Liposomal bupivacaine +1 more
    PhasePhase 3
    Registry statusUnknown

  • Study Evaluating Abuse Potential of Lyrica® in Healthy Non-Drug Dependent Recreational Opioid Users

    NCT05053126 · start 2021-07-27

    Registered record
    Registry ID
    NCT05053126
    Conditions
    Abuse Potential
    Interventions
    Pregabalin 300mg; pregabalin 450 mg; Pregabalin 300 mg with oxycodone 20 mg; pregabalin 450 mg with oxycodone 20 mg; oxycodone 20 mg; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-07-27
    Completion
    2022-04-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbuse Potential
    InterventionPregabalin 300mg; pregabalin 450 mg; Pregabalin 300 mg with oxycodone 20 mg; pregabalin 450 mg with oxycodone 20 mg +2 more
    PhasePhase 4
    Registry statusCompleted

  • Novel Multimodal Pain Control Protocol for Minimally Invasive Gynecologic Surgery

    NCT04710277 · start 2021-04-19

    Registered record
    Registry ID
    NCT04710277
    Conditions
    Postoperative Pain; Narcotic Use; Cryotherapy Effect
    Interventions
    Opioid-sparing multimodal pain management; Usual care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-04-19
    Completion
    2022-10-20
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain; Narcotic Use; Cryotherapy Effect
    InterventionOpioid-sparing multimodal pain management; Usual care
    PhaseNot applicable
    Registry statusCompleted