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AMR Drug RepurposingSmart Screeningresearch prototype

Oxycodone

FDA-approved product (capsule, extended release, oral), marketed as Xtampza Er, Oxaydo, Oxycodone Hydrochloride and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Oxycodone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Chronic pain
  • Drug dependence
  • Pain
  • Substance abuse

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Natural opium alkaloids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA42.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae44.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis42.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Oxycodone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Oxycodone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Depot-opioids for Pre- and Postoperative Pain Relief After Primary Knee Arthroplasty.Tapentadol vs Oxycodone vs Placebo

    NCT02604446 · start 2015-09

    Registered record
    Registry ID
    NCT02604446
    Conditions
    Joint Diseases
    Interventions
    Tapentadol; Oxycodone; Placebo; usual pain treatment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-09
    Completion
    2019-02
    Enrolment
    134

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionJoint Diseases
    InterventionTapentadol; Oxycodone; Placebo; usual pain treatment
    PhasePhase 3
    Registry statusCompleted

  • Optimal Dose of i.v Oxycodone for Postoperative Pain After Laparoscopic Colorectal Surgery

    NCT02240602 · start 2015-07

    Registered record
    Registry ID
    NCT02240602
    Conditions
    Pain
    Interventions
    Oxycodone, 1.00 mg dose; Oxycodone, 0.03 mg/kg dose; Oxycodone, 0.02 mg/kg dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2015-07
    Completion
    2016-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionOxycodone, 1.00 mg dose; Oxycodone, 0.03 mg/kg dose; Oxycodone, 0.02 mg/kg dose
    PhasePhase 3
    Registry statusWithdrawn

  • The Safety and Efficacy of Epidural Oxycodone

    NCT02573909 · start 2015-01-01

    Registered record
    Registry ID
    NCT02573909
    Conditions
    Pain, Postoperative
    Interventions
    Oxycodone intravenously; Oxycodone epidurally
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-01-01
    Completion
    2023-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative
    InterventionOxycodone intravenously; Oxycodone epidurally
    PhasePhase 4
    Registry statusUnknown

  • Ethnicity and Analgesic Practice in a Pediatric Emergency Department

    NCT02322463 · start 2014-12

    Registered record
    Registry ID
    NCT02322463
    Conditions
    Limb Fracture
    Interventions
    Arab children
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2014-12
    Completion
    2015-10
    Enrolment
    5,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLimb Fracture
    InterventionArab children
    PhaseNot recorded
    Registry statusUnknown

  • A Study of TRV130 for the Treatment of Pain After Abdominoplasty

    NCT02335294 · start 2014-12

    Registered record
    Registry ID
    NCT02335294
    Conditions
    Pain
    Interventions
    TRV130; Morphine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-12
    Completion
    2015-08
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionTRV130; Morphine; Placebo
    PhasePhase 2
    Registry statusCompleted

  • A Randomized, Open Label, Prospective Study to Explore the Clinical Characteristics of Oral MNK155 and Norco 7.5mg/325 When Used for the Treatment of Moderate to Severe Post Operative Pain

    NCT02381132 · start 2014-11

    Registered record
    Registry ID
    NCT02381132
    Conditions
    Post Operative Pain
    Interventions
    Norco 7.5mg/325; MNK155
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2014-11
    Completion
    2015-12
    Enrolment
    99

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Operative Pain
    InterventionNorco 7.5mg/325; MNK155
    PhasePhase 3
    Registry statusTerminated

  • Operative Treatment of Unstable Thoracic Cage Injuries and Chest Wall Deformity in Trauma

    NCT02132416 · start 2014-05

    Registered record
    Registry ID
    NCT02132416
    Conditions
    Trauma; Flail Chest; Rib Fractures; Surgery
    Interventions
    NSAID; Opioids; Thoracic Epidural anaesthesia; Paracetamol; Surgical management
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-05
    Completion
    2018-12
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTrauma; Flail Chest; Rib Fractures; Surgery
    InterventionNSAID; Opioids; Thoracic Epidural anaesthesia; Paracetamol +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Effects of Food on Oxycodone Pharmacokinetics in Healthy Volunteers

    NCT02117583 · start 2014-04

    Registered record
    Registry ID
    NCT02117583
    Conditions
    Healthy
    Interventions
    Oxycodone; Oxycodone; Oxycodone; Oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-04
    Completion
    2014-08
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionOxycodone; Oxycodone; Oxycodone; Oxycodone
    PhasePhase 1
    Registry statusCompleted

  • A Study to Characterize the Abuse Liability of Intravenous Oxycodone Alone or in Combination With Intravenous Naltrexone in Healthy, Non-Dependent, Recreational Opioid Users

    NCT01825447 · start 2013-07

    Registered record
    Registry ID
    NCT01825447
    Conditions
    Healthy
    Interventions
    Placebo; Oxycodone + Naltrexone; Oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-07
    Completion
    2013-09
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionPlacebo; Oxycodone + Naltrexone; Oxycodone
    PhasePhase 1
    Registry statusCompleted

  • The Assessments of the Postoperative Recovery on Elderly Patients Received General Anesthesia or Peripheral Nerve Blocks

    NCT01782612 · start 2013-03

    Registered record
    Registry ID
    NCT01782612
    Conditions
    Anesthesia; Hip Osteoarthritis
    Interventions
    Multimodal analgesic techniques; Total uni-Hip Replacement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2013-03
    Completion
    2014-03
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Hip Osteoarthritis
    InterventionMultimodal analgesic techniques; Total uni-Hip Replacement
    PhaseNot applicable
    Registry statusUnknown

  • A Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN)

    NCT01675531 · start 2012-12

    Registered record
    Registry ID
    NCT01675531
    Conditions
    Cancer
    Interventions
    Targin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-12
    Completion
    2014-06
    Enrolment
    73

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCancer
    InterventionTargin
    PhasePhase 4
    Registry statusCompleted

  • PROspective Non-interventional Open laBEl Trial for TARGIN in Korean Patients With Cancer Pain

    NCT01719757 · start 2012-07

    Registered record
    Registry ID
    NCT01719757
    Conditions
    Cancer
    Interventions
    Oxycodone/Naloxone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-07
    Completion
    2014-04
    Enrolment
    359

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCancer
    InterventionOxycodone/Naloxone
    PhasePhase 4
    Registry statusCompleted

  • A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

    NCT01427283 · start 2011-08

    Registered record
    Registry ID
    NCT01427283
    Conditions
    Low Back Pain
    Interventions
    Oxycodone/Naloxone controlled-release; Oxycodone HCl controlled-release; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-08
    Completion
    2014-10
    Enrolment
    450

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain
    InterventionOxycodone/Naloxone controlled-release; Oxycodone HCl controlled-release; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Evaluation of the Efficacy and Tolerability of Etoricoxib Monotherapy Versus Combination Oxycodone-etoricoxib in Moderate to Severe Pain From Chronic Low Back Pain

    NCT01344720 · start 2011-05

    Registered record
    Registry ID
    NCT01344720
    Conditions
    Low Back Pain
    Interventions
    etoricoxib; oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-05
    Completion
    2011-06
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain
    Interventionetoricoxib; oxycodone
    PhasePhase 4
    Registry statusUnknown

  • A Non-interventional, Observational Study for Targinact® Treatment in Patients With Severe Pain.

    NCT01983137 · start 2011-04

    Registered record
    Registry ID
    NCT01983137
    Conditions
    Severe Pain
    Interventions
    Targinact® (oxycodone/naloxone)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-04
    Completion
    2012-12
    Enrolment
    1,338

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSevere Pain
    InterventionTarginact® (oxycodone/naloxone)
    PhaseNot recorded
    Registry statusCompleted