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AMR Drug RepurposingSmart Screeningresearch prototype

Cetyl Alcohol

FDA-approved product (for suspension, intratracheal).

Registered studies
29
Lab records
1
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Cetyl Alcohol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Cetyl Alcohol. Its therapeutic class is shown instead.

Anti-infective classification
Neither a WHO ATC code nor an FDA pharmacologic class was found for it, so whether it is already an antimicrobial is not established. It needs review and is not counted as a repurposing candidate.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Cetyl Alcohol, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA12.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli3.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae7.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis6.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

29registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 0 of 1 lab record
Open Cetyl Alcohol in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cetyl Alcohol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Treatment of Prepubertal Labial Adhesions

    NCT02218463 · start 2014-09

    Registered record
    Registry ID
    NCT02218463
    Conditions
    Prepubertal Labial Adhesions
    Interventions
    Estradiol cream 0.01%; Cetaphil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-09
    Completion
    2016-06
    Enrolment
    43

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrepubertal Labial Adhesions
    InterventionEstradiol cream 0.01%; Cetaphil
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy and Safety of Kinetin 0.1% for Treatment of Skin Photoaging

    NCT01898182 · start 2013-11

    Registered record
    Registry ID
    NCT01898182
    Conditions
    Cutaneous Photoaging
    Interventions
    Kinetin, N6-furfuryladenine, 0.1%
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-11
    Completion
    2014-09
    Enrolment
    132

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCutaneous Photoaging
    InterventionKinetin, N6-furfuryladenine, 0.1%
    PhasePhase 4
    Registry statusCompleted

  • Novel Topical Therapies for the Treatment of Genital Pain

    NCT02099006 · start 2013-11

    Registered record
    Registry ID
    NCT02099006
    Conditions
    Female Genital Diseases
    Interventions
    Amitriptyline; Baclofen; Ketoprofen; Ketamine; Loperamide; Gabapentin; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2013-11
    Completion
    2015-06
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFemale Genital Diseases
    InterventionAmitriptyline; Baclofen; Ketoprofen; Ketamine +3 more
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Transcranial Direct Current Stimulation Combined Sensory Modulation Intervention in Chronic Stroke Patients

    NCT01847157 · start 2013-01

    Registered record
    Registry ID
    NCT01847157
    Conditions
    Stroke
    Interventions
    tDCS; Epidermis anesthesia; sham anesthesia; Repeated passive movement; sham tDCS
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-01
    Completion
    2015-06
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStroke
    InterventiontDCS; Epidermis anesthesia; sham anesthesia; Repeated passive movement +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Two Commercially Available Chlorhexidine Mouthrinses Non-alcohol Base

    NCT01580943 · start 2011-10

    Registered record
    Registry ID
    NCT01580943
    Conditions
    Dental Plaque
    Interventions
    Chlorhexidine; Chlorhexidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2011-10
    Completion
    2012-03
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque
    InterventionChlorhexidine; Chlorhexidine
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation

    NCT01542138 · start 2011-07

    Registered record
    Registry ID
    NCT01542138
    Conditions
    Hyperpigmentation
    Interventions
    Desonide; Niacinamide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-07
    Completion
    2012-11
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyperpigmentation
    InterventionDesonide; Niacinamide; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Cryosurgery and Cream Combination for Actinic Keratosis

    NCT03037541 · start 2011-01-05

    Registered record
    Registry ID
    NCT03037541
    Conditions
    Actinic Keratosis
    Interventions
    Carac Cream; Placebo Cetaphil cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-01-05
    Completion
    2013-10-29
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionCarac Cream; Placebo Cetaphil cream
    PhasePhase 3
    Registry statusCompleted

  • Hexetidine and Chlorobutanol for Lesions Due to Prostheses

    NCT01115049 · start 2010-02

    Registered record
    Registry ID
    NCT01115049
    Conditions
    Oral Mucositis
    Interventions
    chlorobutanol, hexetidine; Chlorhexidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-02
    Completion
    2010-03
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Mucositis
    Interventionchlorobutanol, hexetidine; Chlorhexidine
    PhasePhase 4
    Registry statusCompleted

  • Adjunctive Usage of a Moisturizing Lotion (Cetaphil® Moisturizing Lotion) to Limit the Skin Irritation Linked to the Set-Up of a Treatment by Topical Retinoid (Differin® Gel 0,1%) in Healthy Subjects of Chinese Origins

    NCT00971282 · start 2008-12

    Registered record
    Registry ID
    NCT00971282
    Conditions
    Healthy Skin
    Interventions
    adapalen 0.1%; Cetaphil®
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-12
    Completion
    2009-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Skin
    Interventionadapalen 0.1%; Cetaphil®
    PhasePhase 4
    Registry statusCompleted

  • Hydrogel Patch for the Treatment of Eczema

    NCT00924508 · start 2008-07

    Registered record
    Registry ID
    NCT00924508
    Conditions
    Eczema
    Interventions
    hydrogel patch; Triamcinolone (TAC) 0.1% cream
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-07
    Completion
    2012-07
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEczema
    Interventionhydrogel patch; Triamcinolone (TAC) 0.1% cream
    PhaseNot applicable
    Registry statusTerminated

  • Trial of Methyl Aminolevulinate Plus Aktilite in Facial Photodamage

    NCT00629317 · start 2008-02

    Registered record
    Registry ID
    NCT00629317
    Conditions
    Skin Aging
    Interventions
    Moisturizer; Methyl Aminolevulinate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-02
    Completion
    2009-03
    Enrolment
    49

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Aging
    InterventionMoisturizer; Methyl Aminolevulinate
    PhasePhase 3
    Registry statusCompleted

  • Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects

    NCT00655811 · start 2008-02

    Registered record
    Registry ID
    NCT00655811
    Conditions
    Healthy
    Interventions
    Capsaicin; Placebo moisturizing cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-02
    Completion
    2009-10
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCapsaicin; Placebo moisturizing cream
    PhasePhase 4
    Registry statusCompleted

  • Comparative Study of the Efficacy of SARNA Sensitive Lotion for Treatment of Uremic Itch in Adult Hemodialysis Patients

    NCT00693654 · start 2006-11

    Registered record
    Registry ID
    NCT00693654
    Conditions
    Pruritis
    Interventions
    Sarna; Cetaphil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-11
    Completion
    2008-10
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPruritis
    InterventionSarna; Cetaphil
    PhasePhase 4
    Registry statusCompleted

  • A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars

    NCT00754247 · start 2006-03

    Registered record
    Registry ID
    NCT00754247
    Conditions
    Keloid; Hypertrophic Scar; Cicatrix, Hypertrophic
    Interventions
    0.5% hydrocortisone, silicone, vitamin E lotion; Onion extract gel; Cetearyl alcohol lotion
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-03
    Completion
    2008-02
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeloid; Hypertrophic Scar; Cicatrix, Hypertrophic
    Intervention0.5% hydrocortisone, silicone, vitamin E lotion; Onion extract gel; Cetearyl alcohol lotion
    PhasePhase 4
    Registry statusCompleted