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AMR Drug RepurposingSmart Screeningresearch prototype

Didanosine

FDA-approved product (tablet, chewable, oral), marketed as Didanosine, Videx, Videx Ec.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Didanosine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • HIV infection
  • Viral disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Nucleoside and nucleotide reverse transcriptase inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AF02

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Didanosine, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA34.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae33.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Didanosine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Didanosine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study to Compare the Effectiveness of Different Anti-HIV Drug Regimens in Keeping Levels of HIV in the Blood as Low as Possible

    NCT00000939

    Registered record
    Registry ID
    NCT00000939
    Conditions
    HIV Infections
    Interventions
    Hydroxyurea; Efavirenz; Stavudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2000-01
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionHydroxyurea; Efavirenz; Stavudine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • A Study of Chemotherapy Plus ddI or ddC in the Treatment of AIDS-Related Kaposi's Sarcoma

    NCT00000954

    Registered record
    Registry ID
    NCT00000954
    Conditions
    Sarcoma, Kaposi; HIV Infections
    Interventions
    Bleomycin sulfate; Vincristine sulfate; Doxorubicin hydrochloride; Zalcitabine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1996-09
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSarcoma, Kaposi; HIV Infections
    InterventionBleomycin sulfate; Vincristine sulfate; Doxorubicin hydrochloride; Zalcitabine +1 more
    PhasePhase 1
    Registry statusCompleted

  • Evaluation of Patients Who Have Not Had Success With Zidovudine

    NCT00001025

    Registered record
    Registry ID
    NCT00001025
    Conditions
    HIV Infections
    Interventions
    Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1995-05
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionZidovudine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • A Comparison of Three Treatments for Advanced HIV Disease in Patients Who Have Received Nucleoside Therapy in the Past

    NCT00001029

    Registered record
    Registry ID
    NCT00001029
    Conditions
    HIV Infections
    Interventions
    Zidovudine; Zalcitabine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1993-05
    Enrolment
    654

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionZidovudine; Zalcitabine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • The Effectiveness of Two Anti-HIV Treatments in HIV-Infected Patients

    NCT00001057

    Registered record
    Registry ID
    NCT00001057
    Conditions
    HIV Infections
    Interventions
    Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1995-05
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionZidovudine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • The Effectiveness of Three Drug Combinations in HIV-Infected Patients Who Have Taken Zidovudine for More Than 12 Weeks

    NCT00001063

    Registered record
    Registry ID
    NCT00001063
    Conditions
    HIV Infections
    Interventions
    Stavudine; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1997-11
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionStavudine; Zidovudine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • A Comparison of Zidovudine Plus Lamivudine Versus ddI Used Alone or in Combination With Zidovudine in HIV-1 Infected Children

    NCT00001066

    Registered record
    Registry ID
    NCT00001066
    Conditions
    HIV Infections
    Interventions
    Lamivudine; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    740

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionLamivudine; Zidovudine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • The Safety and Effectiveness of Hydroxyurea and ddI Used Individually or Together in HIV-Infected Patients

    NCT00001074

    Registered record
    Registry ID
    NCT00001074
    Conditions
    HIV Infections
    Interventions
    Hydroxyurea; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2000-01
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionHydroxyurea; Didanosine
    PhasePhase 1
    Registry statusCompleted

  • A Study of an Adherence Plan to Help HIV-Positive Patients Take Their First Anti-HIV Medications Correctly

    NCT00001122

    Registered record
    Registry ID
    NCT00001122
    Conditions
    HIV Infections
    Interventions
    Nelfinavir mesylate; Efavirenz; Stavudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNelfinavir mesylate; Efavirenz; Stavudine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • Safety and Efficacy of Polyethylene Glycolated IL-2 (PEG IL-2) Plus Zidovudine or Dideoxyinosine in HIV Positive, Asymptomatic and Symptomatic Individuals

    NCT00001997

    Registered record
    Registry ID
    NCT00001997
    Conditions
    HIV Infections
    Interventions
    Interleukin-2, Polyethylene Glycolated; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionInterleukin-2, Polyethylene Glycolated; Zidovudine; Didanosine
    PhaseNot applicable
    Registry statusCompleted

  • Phase II/III Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients

    NCT00002099

    Registered record
    Registry ID
    NCT00002099
    Conditions
    HIV Infections
    Interventions
    Lentinan; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionLentinan; Didanosine
    PhasePhase 2
    Registry statusUnknown

  • Double-Blind Study of Timunox (Thymopentin) in Asymptomatic HIV-Infected Patients Receiving Either Mono (AZT or ddI) or Combination (AZT / ddI or AZT / ddC) Anti-Retroviral Therapy

    NCT00002109

    Registered record
    Registry ID
    NCT00002109
    Conditions
    HIV Infections
    Interventions
    Thymopentin; Stavudine; Zidovudine; Zalcitabine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionThymopentin; Stavudine; Zidovudine; Zalcitabine +1 more
    PhasePhase 3
    Registry statusCompleted

  • A Comparison of Two Anti-HIV Triple-Drug Combinations in HIV-Infected Patients

    NCT00002168

    Registered record
    Registry ID
    NCT00002168
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Lamivudine; Stavudine; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Lamivudine; Stavudine; Zidovudine +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Safety and Effectiveness of Giving Combinations of Three or Four Anti-HIV Drugs to HIV-Infected Patients

    NCT00002211

    Registered record
    Registry ID
    NCT00002211
    Conditions
    HIV Infections
    Interventions
    Nelfinavir mesylate; Delavirdine mesylate; Stavudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNelfinavir mesylate; Delavirdine mesylate; Stavudine; Didanosine
    PhaseNot applicable
    Registry statusCompleted

  • A Study of ddI in Patients With AIDS Who Become Sicker While Taking Zidovudine

    NCT00002274

    Registered record
    Registry ID
    NCT00002274
    Conditions
    HIV Infections; Leukoencephalopathy, Progressive Multifocal
    Interventions
    Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Leukoencephalopathy, Progressive Multifocal
    InterventionDidanosine
    PhaseNot applicable
    Registry statusCompleted