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AMR Drug RepurposingSmart Screeningresearch prototype

Clobetasol Propionate

FDA-approved product (cream, topical), marketed as Byqlovi, Clobetasol Propionate, Clobetasol Propionate (Emollient) and 10 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Clobetasol Propionate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Psoriasis
  • Psoriasis vulgaris
  • Skin disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids, very potent (group iv)
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae29.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis35.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Clobetasol Propionate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clobetasol Propionate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Treatment Protocols for Patients With Symptomatic Oral Lichen Planus

    NCT04673916 · start 2019-06-01

    Registered record
    Registry ID
    NCT04673916
    Conditions
    Lichen Planus, Oral; Preneoplastic Condition
    Interventions
    Healing evaluation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-06-01
    Completion
    2020-06-25
    Enrolment
    61

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLichen Planus, Oral; Preneoplastic Condition
    InterventionHealing evaluation
    PhaseNot applicable
    Registry statusCompleted

  • PRF in Management of Chronic Multiple Oral Ulcers

    NCT03878771 · start 2019-03-13

    Registered record
    Registry ID
    NCT03878771
    Conditions
    Oral Ulcer Due to Pemphius Vularis; Oral Ulcer Due to Benign Mucous Membrane Pemphioid; Oral Ulcer Due to Steven Johnson's Syndrome
    Interventions
    Platelet rich fibrin gel in Orabase; Dermovate cream in Orabase
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-03-13
    Completion
    2019-04-15
    Enrolment
    804

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Ulcer Due to Pemphius Vularis; Oral Ulcer Due to Benign Mucous Membrane Pemphioid; Oral Ulcer Due to Steven Johnson's Syndrome
    InterventionPlatelet rich fibrin gel in Orabase; Dermovate cream in Orabase
    PhasePhase 1
    Registry statusCompleted

  • Fractional Laser and Steroid Ointment to Improve the Old Scar After Thyroidectomy

    NCT04719559 · start 2018-03-20

    Registered record
    Registry ID
    NCT04719559
    Conditions
    Thyroid; Wound; Steroid Acne
    Interventions
    Laser-assisted drug delivery
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-03-20
    Completion
    2019-04-02
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThyroid; Wound; Steroid Acne
    InterventionLaser-assisted drug delivery
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus

    NCT03386643 · start 2017-11-06

    Registered record
    Registry ID
    NCT03386643
    Conditions
    Oral Lichen Planus
    Interventions
    Bifidobacterium animalis subsp. lactis HN019; Clobetasol propionate 0.05%
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-11-06
    Completion
    2019-12-06
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Lichen Planus
    InterventionBifidobacterium animalis subsp. lactis HN019; Clobetasol propionate 0.05%
    PhasePhase 2
    Registry statusCompleted

  • Comparative Effectiveness Trial in the Treatment of Pediatric Plaque Morphea

    NCT02680717 · start 2016-03

    Registered record
    Registry ID
    NCT02680717
    Conditions
    Scleroderma
    Interventions
    Clobetasol; Calcipotriene; Tacrolimus
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2016-03
    Completion
    2017-05
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScleroderma
    InterventionClobetasol; Calcipotriene; Tacrolimus
    PhasePhase 1
    Registry statusWithdrawn

  • Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata

    NCT03535233 · start 2016-03

    Registered record
    Registry ID
    NCT03535233
    Conditions
    Alopecia Areata
    Interventions
    Triamcinolone Acetonide; Minoxidil 5 % Topical Spray; clobetasol propionate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-03
    Completion
    2017-09
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlopecia Areata
    InterventionTriamcinolone Acetonide; Minoxidil 5 % Topical Spray; clobetasol propionate
    PhasePhase 4
    Registry statusCompleted

  • A Study of the Efficacy and Safety of DFD-06 Cream in the Treatment of Moderate to Severe Plaque Psoriasis

    NCT02445807 · start 2015-12

    Registered record
    Registry ID
    NCT02445807
    Conditions
    Chronic Stable Plaque Psoriasis
    Interventions
    DFD06-Cream; Vehicle Cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-12
    Completion
    2016-07
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Stable Plaque Psoriasis
    InterventionDFD06-Cream; Vehicle Cream
    PhasePhase 3
    Registry statusCompleted

  • A Study of the Efficacy and Safety of DFD-06 Cream in the Treatment of Moderate to Severe Plaque Psoriasis

    NCT02635204 · start 2015-12

    Registered record
    Registry ID
    NCT02635204
    Conditions
    Psoriasis
    Interventions
    DFD06 Cream; Vehicle Cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-12
    Completion
    2016-07
    Enrolment
    267

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis
    InterventionDFD06 Cream; Vehicle Cream
    PhasePhase 3
    Registry statusCompleted

  • Clobetasol Propionate Versus Fractionated Carbon Dioxide Laser for the Treatment of Lichen Sclerosus

    NCT02573883 · start 2015-10

    Registered record
    Registry ID
    NCT02573883
    Conditions
    Vulvar Lichen Sclerosus
    Interventions
    Fractionated Carbon Dioxide Laser; Clobetasol Propionate 0.05% ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-10
    Completion
    2019-09
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVulvar Lichen Sclerosus
    InterventionFractionated Carbon Dioxide Laser; Clobetasol Propionate 0.05% ointment
    PhasePhase 3
    Registry statusCompleted

  • A Clinical Trial to Compare Topical Agents in Adults With Mild to Moderate Atopic Dermatitis (AD)

    NCT02376049 · start 2015-02

    Registered record
    Registry ID
    NCT02376049
    Conditions
    Atopic Dermatitis
    Interventions
    Pimecrolimus cream; Betamethasone dipropionate cream; Clobetasol propionate cream; Glaxal Base cream vehicle
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-02
    Completion
    2015-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtopic Dermatitis
    InterventionPimecrolimus cream; Betamethasone dipropionate cream; Clobetasol propionate cream; Glaxal Base cream vehicle
    PhasePhase 1
    Registry statusCompleted

  • Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser

    NCT02492373 · start 2015-02

    Registered record
    Registry ID
    NCT02492373
    Conditions
    Lentigines; Post Inflammatory Hyperpigmentation
    Interventions
    topical 0.05% Clobetasol propionate ointment; Q switched Nd:YAG laser 532 nm
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-02
    Completion
    2016-05
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLentigines; Post Inflammatory Hyperpigmentation
    Interventiontopical 0.05% Clobetasol propionate ointment; Q switched Nd:YAG laser 532 nm
    PhaseNot applicable
    Registry statusCompleted

  • Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser

    NCT02416531 · start 2015-01

    Registered record
    Registry ID
    NCT02416531
    Conditions
    Vulvar Lichen Sclerosus
    Interventions
    Clobetasol propionate; Photodynamic therapy; Low level laser therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-01
    Completion
    2017-10
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVulvar Lichen Sclerosus
    InterventionClobetasol propionate; Photodynamic therapy; Low level laser therapy
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus

    NCT02744378 · start 2014-06

    Registered record
    Registry ID
    NCT02744378
    Conditions
    Oral Lichen Planus
    Interventions
    Tacrolimus 0.1%; Clobetasol 0.05%
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-06
    Completion
    2015-12
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Lichen Planus
    InterventionTacrolimus 0.1%; Clobetasol 0.05%
    PhasePhase 2
    Registry statusCompleted

  • DFD06 Cream vs Clobetasol Propionate Cream, 0.05% Hypothalamic- Pituitary-Adrenal (HPA) Axis Suppression Study in Patients With Moderate to Severe Plaque Psoriasis

    NCT02131324 · start 2014-05-08

    Registered record
    Registry ID
    NCT02131324
    Conditions
    Psoriasis
    Interventions
    DFD06 Cream; Clobetasol Propionate Cream 0.05%
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-05-08
    Completion
    2016-08-11
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis
    InterventionDFD06 Cream; Clobetasol Propionate Cream 0.05%
    PhasePhase 2
    Registry statusCompleted

  • Comparison Between Corticosteroid and Topical Steroids in the DRESS

    NCT01987076 · start 2013-10

    Registered record
    Registry ID
    NCT01987076
    Conditions
    Drug Rash With Eosinophilia and Systemic Symptoms
    Interventions
    Prednisone; Clobetasol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2013-10
    Completion
    2016-10
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Rash With Eosinophilia and Systemic Symptoms
    InterventionPrednisone; Clobetasol
    PhaseNot applicable
    Registry statusUnknown