Clobetasol Propionate
FDA-approved product (cream, topical), marketed as Byqlovi, Clobetasol Propionate, Clobetasol Propionate (Emollient) and 10 more.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Psoriasis
- Psoriasis vulgaris
- Skin disease
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Corticosteroids, very potent (group iv)
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA52.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli35.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae29.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis35.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Clobetasol Propionate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Mefloquine HydrochlorideExisting use: Malaria, Plasmodium falciparum malaria, Plasmodium vivax malaria81.8% AI-predicted activityagainst M. tuberculosisLab records exist8 registered studies
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Maintenance Effect of Clobex Shampoo on Participants With Moderate to Severe Scalp Psoriasis
NCT00400725 · start 2006-09-29
Registered record
- Registry ID
- NCT00400725
- Conditions
- Scalp Psoriasis
- Interventions
- Clobex® Shampoo; Clobex® Vehicle Shampoo; Clobex® Shampoo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2006-09-29
- Completion
- 2007-08-20
- Enrolment
- 288
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionScalp PsoriasisInterventionClobex® Shampoo; Clobex® Vehicle Shampoo; Clobex® ShampooPhasePhase 3Registry statusCompletedEfficacy, Tolerance and Satisfaction With CLOBEX® Spray When Used as Monotherapy or Add-on Therapy in Plaque Psoriasis
NCT00437216 · start 2006-02
Registered record
- Registry ID
- NCT00437216
- Conditions
- Psoriasis
- Interventions
- Clobetasol Propionate, 0.05%; Clobetasol propionate, 0.05% Spray
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2006-02
- Completion
- 2006-07
- Enrolment
- 2,488
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPsoriasisInterventionClobetasol Propionate, 0.05%; Clobetasol propionate, 0.05% SprayPhaseNot recordedRegistry statusCompletedPivotal Bioequivalence Study of Topically Delivered Clobetasol Propionate Lotion in Healthy Adult Subjects
NCT00864500 · start 2005-11
Registered record
- Registry ID
- NCT00864500
- Conditions
- Healthy
- Interventions
- Clobetasol Propionate 0.05% lotion, single exposure; Clobex TM 0.05% Lotion, single exposure
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2005-11
- Completion
- 2006-02
- Enrolment
- 224
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHealthyInterventionClobetasol Propionate 0.05% lotion, single exposure; Clobex TM 0.05% Lotion, single exposurePhasePhase 1Registry statusCompletedHydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus
NCT00102557 · start 2005-01
Registered record
- Registry ID
- NCT00102557
- Conditions
- Lichen Planus, Oral
- Interventions
- Hydroxychloroquine
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2005-01
- Completion
- 2005-10
- Enrolment
- 74
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLichen Planus, OralInterventionHydroxychloroquinePhasePhase 2Registry statusCompletedValacyclovir+Temovate Gel for the Treatment of Herpes Labialis
NCT00297011 · start 2004-09
Registered record
- Registry ID
- NCT00297011
- Conditions
- Herpes Labialis
- Interventions
- valacyclovir+clobetasol gel
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2004-09
- Completion
- 2008-01
- Enrolment
- 300
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHerpes LabialisInterventionvalacyclovir+clobetasol gelPhasePhase 2Registry statusCompleted