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AMR Drug RepurposingSmart Screeningresearch prototype

Indinavir Sulfate

FDA-approved product (capsule, oral), marketed as Crixivan.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Indinavir Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • HIV infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Protease inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AE02

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli52.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Indinavir Sulfate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Indinavir Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study to Evaluate the Long-Term Effectiveness of Three Anti-HIV Drug Regimens in HIV Infected Patients Who Have Never Been Exposed to Highly Active Antiretroviral Therapy (HAART)

    NCT00000922

    Registered record
    Registry ID
    NCT00000922
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Abacavir sulfate; Nelfinavir mesylate; Efavirenz; Nevirapine; Lamivudine; Stavudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2006-06
    Enrolment
    1,710

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Abacavir sulfate; Nelfinavir mesylate; Efavirenz +4 more
    PhaseNot applicable
    Registry statusCompleted

  • Treatment With Interleukin-2 (IL-2) Plus Combination Anti-HIV-Drug Therapy (HAART) for Patients Formerly in ACTG 328

    NCT00000923

    Registered record
    Registry ID
    NCT00000923
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Lamivudine; Stavudine; Zidovudine; Didanosine; Aldesleukin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2004-08
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Lamivudine; Stavudine; Zidovudine +2 more
    PhaseNot applicable
    Registry statusCompleted

  • A Study of Three Treatment Combinations Using Zidovudine Plus Lamivudine Plus Indinavir in HIV-Infected Patients

    NCT00001084

    Registered record
    Registry ID
    NCT00001084
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Lamivudine; Stavudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1997-12
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Lamivudine; Stavudine; Zidovudine
    PhasePhase 2
    Registry statusCompleted

  • A Study of Three Anti-HIV Drug Combinations in Patients Who Have Taken Amprenavir

    NCT00001095

    Registered record
    Registry ID
    NCT00001095
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Amprenavir; Nevirapine; Lamivudine; Stavudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1999-10
    Enrolment
    94

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Amprenavir; Nevirapine; Lamivudine +2 more
    PhasePhase 2
    Registry statusCompleted

  • Safety and Tolerance of Indinavir Plus Ritonavir in HIV-Positive Patients Failing Therapy With Amprenavir, Nelfinavir, or Saquinavir

    NCT00001133

    Registered record
    Registry ID
    NCT00001133
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Ritonavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2006-08
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Ritonavir
    PhasePhase 1
    Registry statusCompleted

  • A Comparison of Two Anti-HIV Triple-Drug Combinations in HIV-Infected Patients

    NCT00002168

    Registered record
    Registry ID
    NCT00002168
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Lamivudine; Stavudine; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Lamivudine; Stavudine; Zidovudine +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Indinavir Plus Efavirenz Plus Adefovir Dipivoxil in HIV-Infected Patients Who Have Not Had Success With Nelfinavir

    NCT00002220

    Registered record
    Registry ID
    NCT00002220
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Efavirenz; Levocarnitine; Adefovir dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Efavirenz; Levocarnitine; Adefovir dipivoxil
    PhasePhase 3
    Registry statusCompleted

  • A Study of Indinavir Sulfate Given Together With Stavudine to HIV-Positive Patients

    NCT00002354

    Registered record
    Registry ID
    NCT00002354
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Stavudine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    540

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Stavudine
    PhaseNot applicable
    Registry statusCompleted

  • Safety and Effectiveness of an Anti-HIV Drug Combination in HIV-Positive Patients Who Have Failed Previous Treatment With Protease Inhibitors

    NCT00002361

    Registered record
    Registry ID
    NCT00002361
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Ritonavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Ritonavir
    PhasePhase 2
    Registry statusCompleted

  • A Study of 141W94 in Combination With Other Anti-HIV Drugs

    NCT00002372

    Registered record
    Registry ID
    NCT00002372
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Amprenavir; Nelfinavir mesylate; Saquinavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Amprenavir; Nelfinavir mesylate; Saquinavir
    PhasePhase 1
    Registry statusCompleted

  • Safety and Effectiveness of Giving Indinavir and Nelfinavir to HIV-Infected Patients

    NCT00002375

    Registered record
    Registry ID
    NCT00002375
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Nelfinavir mesylate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Nelfinavir mesylate
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Indinavir Plus Two Other Anti-HIV Drugs on Blood Clotting in HIV-Positive Males With Hemophilia

    NCT00002386

    Registered record
    Registry ID
    NCT00002386
    Conditions
    HIV Infections; Hemophilia A
    Interventions
    Indinavir sulfate; Lamivudine; Stavudine; Zidovudine; Zalcitabine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Hemophilia A
    InterventionIndinavir sulfate; Lamivudine; Stavudine; Zidovudine +2 more
    PhasePhase 4
    Registry statusCompleted

  • A Study of Indinavir Taken With or Without DMP 266

    NCT00002393

    Registered record
    Registry ID
    NCT00002393
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Efavirenz
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Efavirenz
    PhasePhase 3
    Registry statusCompleted

  • A Study of Delavirdine Used Together With Other Anti-HIV Drugs in HIV-Infected Patients

    NCT00002401

    Registered record
    Registry ID
    NCT00002401
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Delavirdine mesylate; Lamivudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Delavirdine mesylate; Lamivudine; Zidovudine
    PhaseNot applicable
    Registry statusCompleted

  • A Comparison of Two Dose Levels of Indinavir Combined With Two Nucleoside Analogue Reverse Transcriptase Inhibitors (NRTIs) in HIV-Infected Patients

    NCT00002406

    Registered record
    Registry ID
    NCT00002406
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate
    PhasePhase 3
    Registry statusCompleted