Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Methyclothiazide

FDA-approved product (tablet, oral), marketed as Aquatensen, Enduron, Methyclothiazide.

Registered studies
5
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Methyclothiazide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Thiazides, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA34.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli35.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis64.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

5registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Methyclothiazide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Methyclothiazide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Analysis of Crosslinked and Conventional Polyethylene Explants

    NCT01484002 · start 2011-12

    Registered record
    Registry ID
    NCT01484002
    Conditions
    Osteoarthritis
    Interventions
    Total hip arthroplasty
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2011-12
    Completion
    2017-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    InterventionTotal hip arthroplasty
    PhaseNot recorded
    Registry statusUnknown

  • A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement

    NCT00208429 · start 2004-07-01

    Registered record
    Registry ID
    NCT00208429
    Conditions
    Rheumatoid Arthritis; Osteoarthritis; Post-traumatic Arthritis; Collagen Disorders; Avascular Necrosis; Traumatic Femoral Fractures; Nonunion of Femoral Fractures; Congenital Hip Dysplasia; Slipped Capital Femoral Epiphysis
    Interventions
    Pinnacle Acetabular System
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2004-07-01
    Completion
    2019-07-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRheumatoid Arthritis; Osteoarthritis; Post-traumatic Arthritis; Collagen Disorders +5 more
    InterventionPinnacle Acetabular System
    PhasePhase 4
    Registry statusWithdrawn

  • A Randomised Single Centre Study to Compare the Long-term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement

    NCT00208442 · start 2001-06-01

    Registered record
    Registry ID
    NCT00208442
    Conditions
    Osteoarthritis; Post-traumatic Arthritis; Collagen Disorders; Avascular Necrosis; Traumatic Femoral Fractures; Nonunion of Femoral Fractures; Congenital Hip Dysplasia; Slipped Capital Femoral Epiphysis
    Interventions
    Marathon™; Enduron
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2001-06-01
    Completion
    2013-09-01
    Enrolment
    122

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis; Post-traumatic Arthritis; Collagen Disorders; Avascular Necrosis +4 more
    InterventionMarathon™; Enduron
    PhasePhase 4
    Registry statusCompleted

  • Marathon and Enduron Polyethylene at Long-Term Follow-up

    NCT02508428 · start 1999-01-06

    Registered record
    Registry ID
    NCT02508428
    Conditions
    Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases
    Interventions
    Hip Replacement with crosslinked Marathon polyethylene; Hip Replacement with noncrosslinked Enduron polyethylene
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    1999-01-06
    Completion
    2017-06-22
    Enrolment
    230

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases +1 more
    InterventionHip Replacement with crosslinked Marathon polyethylene; Hip Replacement with noncrosslinked Enduron polyethylene
    PhaseNot applicable
    Registry statusCompleted

  • Study Comparing Marathon Polyethylene and Enduron Polyethylene Acetabular Liners Used in Total Hip Arthroplasty

    NCT01121146 · start 1998-12

    Registered record
    Registry ID
    NCT01121146
    Conditions
    Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases
    Interventions
    Total Hip Replacement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    1998-12
    Completion
    2012-03
    Enrolment
    236

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases +1 more
    InterventionTotal Hip Replacement
    PhaseNot applicable
    Registry statusCompleted