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AMR Drug RepurposingSmart Screeningresearch prototype

Bacitracin

FDA-approved product (ointment, ophthalmic), marketed as Baci-Rx, Baciguent, Bacitracin and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Bacitracin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Burn
  • Eye infection
  • Infection
  • Inflammation
  • Pneumonia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antibiotics for topical use; Other antibacterials; Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01XX10; WHO ATC D06AX05; WHO ATC R02AB04; WHO ATC S01AA32

Repurposing investigation

Bacitracin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA82.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. A stereoisomer of this medicine was in the model's training data.
  • E. coli65.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae49.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Bacitracin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Bacitracin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Comparison of the Outcomes of Distal Fingertip Amputations Treated With Either Artificial (Xeroform) or Biological Dressings

    NCT03968835 · start 2018-12-24

    Registered record
    Registry ID
    NCT03968835
    Conditions
    Finger Injuries; Amputation, Traumatic
    Interventions
    Bacitracin; Skin Graft
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Withdrawn
    Start
    2018-12-24
    Completion
    2021-05
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFinger Injuries; Amputation, Traumatic
    InterventionBacitracin; Skin Graft
    PhaseNot recorded
    Registry statusWithdrawn

  • The Use of Medical Grade Honey in the Prevention of Bone Anchored Hearing Aid Associated Skin Breakdown

    NCT03929224 · start 2018-10-25

    Registered record
    Registry ID
    NCT03929224
    Conditions
    Skin Infection
    Interventions
    Medicinal honey; Bacitracin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-10-25
    Completion
    2020-09-01
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Infection
    InterventionMedicinal honey; Bacitracin
    PhasePhase 4
    Registry statusCompleted

  • Tacrolimus for Malar Edema

    NCT03715387 · start 2018-10-10

    Registered record
    Registry ID
    NCT03715387
    Conditions
    Edema Face
    Interventions
    Tacrolimus Topical 0.1% Topical Ointment; Polysporin Ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2018-10-10
    Completion
    2019-07-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEdema Face
    InterventionTacrolimus Topical 0.1% Topical Ointment; Polysporin Ointment
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Topical Antibiotic Irrigation (Gentamicin) in Prophylaxis of Midfacial Fracture Surgical Wounds

    NCT03483363 · start 2018-10-09

    Registered record
    Registry ID
    NCT03483363
    Conditions
    Surgical Site Infection
    Interventions
    topical irrigation with gentamicin (80mg diluted in 1L 0.9% normal saline); topical irrigation with sterile normal saline (NS); intravenous (IV) prophylactic antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2018-10-09
    Completion
    2022-01-02
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    Interventiontopical irrigation with gentamicin (80mg diluted in 1L 0.9% normal saline); topical irrigation with sterile normal saline (NS); intravenous (IV) prophylactic antibiotic
    PhasePhase 4
    Registry statusTerminated

  • Topical Antibiotic Prophylaxis for Eyelids

    NCT03199911 · start 2017-10-02

    Registered record
    Registry ID
    NCT03199911
    Conditions
    Antibiotic Side Effect; Eyelid; Wound; Eyelid Diseases; Surgical Wound Infection; Surgical Wound, Recent; Surgical Incision; Skin Cancer Face; Antibiotic Allergy; Surgical Site Infection
    Interventions
    Topical Antibiotic Product; Topical Non-Antibiotic Ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-10-02
    Completion
    2019-11-14
    Enrolment
    401

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAntibiotic Side Effect; Eyelid; Wound; Eyelid Diseases +6 more
    InterventionTopical Antibiotic Product; Topical Non-Antibiotic Ointment
    PhasePhase 4
    Registry statusCompleted

  • Bacterial Biofilms in Reconstructive Breast Prostheses Following Mastectomy

    NCT03213249 · start 2017-07-25

    Registered record
    Registry ID
    NCT03213249
    Conditions
    Breast Implant Infection; Mammoplasty
    Interventions
    Normal saline; Cefazolin; Skin biopsy; Bilateral skin- or nipple-sparing mastectomies; Tissue expander; Breast implant; Autologous flap; Acellular dermal matrix sling; Gentamicin; Bacitracin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2017-07-25
    Completion
    2018-09-26
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Implant Infection; Mammoplasty
    InterventionNormal saline; Cefazolin; Skin biopsy; Bilateral skin- or nipple-sparing mastectomies +6 more
    PhasePhase 1
    Registry statusCompleted

  • Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.

    NCT02809131 · start 2016-04-01

    Registered record
    Registry ID
    NCT02809131
    Conditions
    Sick Sinus Syndrome; Complete Heart Block; Syncope; Chronic Systolic Heart Failure
    Interventions
    polymixin/bacitracin; cephalexin, or levofloxacin, or clindamycin; Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-04-01
    Completion
    2021-09-30
    Enrolment
    1,010

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSick Sinus Syndrome; Complete Heart Block; Syncope; Chronic Systolic Heart Failure
    Interventionpolymixin/bacitracin; cephalexin, or levofloxacin, or clindamycin; Saline
    PhasePhase 3
    Registry statusCompleted

  • The Burn Glove Trial - Hand Burn Dressing Pilot

    NCT02318056 · start 2015-12

    Registered record
    Registry ID
    NCT02318056
    Conditions
    Burns
    Interventions
    Aquacel® Ag Burn Glove; Mepilex® Transfer Ag; antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2015-12
    Completion
    2016-07
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurns
    InterventionAquacel® Ag Burn Glove; Mepilex® Transfer Ag; antibiotic
    PhaseNot applicable
    Registry statusWithdrawn

  • Patient-Centered Comparative Effectiveness Research (CER) Study of Home-based Interventions to Prevent CA-MRSA Infection Recurrence

    NCT02566928 · start 2015-10

    Registered record
    Registry ID
    NCT02566928
    Conditions
    Methicillin-Resistant Staphylococcus Aureus; Recurrence; Staphylococcal Skin Infections; Antibiotic Resistance
    Interventions
    2% mupirocin ointment; Chlorhexidine wash; Hygiene protocol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-10
    Completion
    2018-12-31
    Enrolment
    278

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus; Recurrence; Staphylococcal Skin Infections; Antibiotic Resistance
    Intervention2% mupirocin ointment; Chlorhexidine wash; Hygiene protocol
    PhasePhase 4
    Registry statusUnknown

  • Trial to Test if Antibiotic Ointments & Cream Will Sting After Application on a Minor Wound After Tape Stripping Injury

    NCT02320695 · start 2015-03

    Registered record
    Registry ID
    NCT02320695
    Conditions
    Sting
    Interventions
    Saline; Isopropyl Alcohol; Pain Relieving Cream; Antibiotic/Pain Relieving Ointment; Original Ointment; Pain Relief Ointment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-03
    Completion
    2015-03
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSting
    InterventionSaline; Isopropyl Alcohol; Pain Relieving Cream; Antibiotic/Pain Relieving Ointment +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients

    NCT02106962 · start 2014-04

    Registered record
    Registry ID
    NCT02106962
    Conditions
    Arteriovenous Fistula
    Interventions
    Topical Tranexamic Acid 5% with bacitracin; Topical Tranexamic Acid 25% with bacitracin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-04
    Completion
    2014-08
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArteriovenous Fistula
    InterventionTopical Tranexamic Acid 5% with bacitracin; Topical Tranexamic Acid 25% with bacitracin
    PhasePhase 4
    Registry statusCompleted

  • Patients Response to Early Switch To Oral:Osteomyelitis Study

    NCT02099240 · start 2014-03-06

    Registered record
    Registry ID
    NCT02099240
    Conditions
    Osteomyelitis
    Interventions
    oral antibiotics; intravenous antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2014-03-06
    Completion
    2018-11-07
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventionoral antibiotics; intravenous antibiotics
    PhaseEarly phase 1
    Registry statusTerminated

  • Comparison of Collagenase With Antibiotic Ointment of Minor Partial Thickness Burns

    NCT02673229 · start 2013-09-30

    Registered record
    Registry ID
    NCT02673229
    Conditions
    Burn, Partial Thickness
    Interventions
    Collagenase Santyl; Bacitracin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2013-09-30
    Completion
    2020-03-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurn, Partial Thickness
    InterventionCollagenase Santyl; Bacitracin
    PhasePhase 4
    Registry statusTerminated

  • Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents

    NCT01797562 · start 2012-12-10

    Registered record
    Registry ID
    NCT01797562
    Conditions
    Allergic Contact Dermatitis
    Interventions
    Panels 1.3, 2.2 and 3.2 experimental allergens
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-12-10
    Completion
    2015-09-08
    Enrolment
    116

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Contact Dermatitis
    InterventionPanels 1.3, 2.2 and 3.2 experimental allergens
    PhaseNot applicable
    Registry statusCompleted

  • Prevention of Arrhythmia Device Infection Trial (PADIT)

    NCT01628666 · start 2012-12

    Registered record
    Registry ID
    NCT01628666
    Conditions
    Arrhythmia
    Interventions
    Incremental; Conventional
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-12
    Completion
    2017-09-08
    Enrolment
    12,814

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArrhythmia
    InterventionIncremental; Conventional
    PhasePhase 4
    Registry statusCompleted