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AMR Drug RepurposingSmart Screeningresearch prototype

Bacitracin

FDA-approved product (ointment, ophthalmic), marketed as Baci-Rx, Baciguent, Bacitracin and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Bacitracin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Burn
  • Eye infection
  • Infection
  • Inflammation
  • Pneumonia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antibiotics for topical use; Other antibacterials; Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01XX10; WHO ATC D06AX05; WHO ATC R02AB04; WHO ATC S01AA32

Repurposing investigation

Bacitracin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA82.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. A stereoisomer of this medicine was in the model's training data.
  • E. coli65.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae49.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Bacitracin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Bacitracin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Using Santyl or Bacitracin on Second Degree Burns

    NCT01516463 · start 2012-03

    Registered record
    Registry ID
    NCT01516463
    Conditions
    Burn, Partial Thickness
    Interventions
    Collagenase Santyl; Bacitracin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2012-03
    Completion
    2013-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurn, Partial Thickness
    InterventionCollagenase Santyl; Bacitracin
    PhasePhase 4
    Registry statusWithdrawn

  • The Relationship of Hemoglobin A1c and Diabetic Wound Healing

    NCT01350102 · start 2012-02

    Registered record
    Registry ID
    NCT01350102
    Conditions
    Diabetes, Type 1; Diabetes, Type 2; Foot Ulcer, Diabetic
    Interventions
    Bacitracin; AmeriGel®; Vitamin C
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2012-02
    Completion
    2014-03
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes, Type 1; Diabetes, Type 2; Foot Ulcer, Diabetic
    InterventionBacitracin; AmeriGel®; Vitamin C
    PhasePhase 4
    Registry statusTerminated

  • Comparison of Wound Bed Establishment in Facial Burns

    NCT01668030 · start 2012-02

    Registered record
    Registry ID
    NCT01668030
    Conditions
    Burns
    Interventions
    Enzymatic agent; Bacitracin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-02
    Completion
    2014-08
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurns
    InterventionEnzymatic agent; Bacitracin
    PhasePhase 4
    Registry statusCompleted

  • Healing Effects of HP802-247 Versus Antibiotic Ointment in Mohs Micrographic Surgery Patients

    NCT01359735 · start 2011-05

    Registered record
    Registry ID
    NCT01359735
    Conditions
    Non-melanoma Skin Cancer
    Interventions
    HP802-247; Bacitracin Ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-05
    Completion
    2012-05
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-melanoma Skin Cancer
    InterventionHP802-247; Bacitracin Ointment
    PhasePhase 2
    Registry statusCompleted

  • Prevention of Arrhythmia Device Infection Trial (PADIT)

    NCT01613092 · start 2011-05

    Registered record
    Registry ID
    NCT01613092
    Conditions
    Arrhythmia
    Interventions
    Incremental; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-05
    Completion
    2013-12
    Enrolment
    241

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArrhythmia
    InterventionIncremental; Cefazolin
    PhasePhase 4
    Registry statusCompleted

  • Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge

    NCT01222832 · start 2010-07

    Registered record
    Registry ID
    NCT01222832
    Conditions
    Paranasal Sinus Disease
    Interventions
    Bacitracin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-07
    Completion
    2012-06
    Enrolment
    226

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParanasal Sinus Disease
    InterventionBacitracin
    PhasePhase 2
    Registry statusCompleted

  • Prevention of Arrhythmia Device Infection Trial (PADIT Pilot)

    NCT01002911 · start 2009-12

    Registered record
    Registry ID
    NCT01002911
    Conditions
    Arrythmias
    Interventions
    Cefazolin, Bacitracin, Cefalexin; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-12
    Completion
    2012-01
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArrythmias
    InterventionCefazolin, Bacitracin, Cefalexin; Cefazolin
    PhasePhase 3
    Registry statusCompleted

  • Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections

    NCT00990392 · start 2009-11

    Registered record
    Registry ID
    NCT00990392
    Conditions
    Blood Stream Infections; Skin Diseases, Infectious
    Interventions
    Polysporin Triple Therapy ointment; Petroleum Jelly
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2009-11
    Completion
    2011-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlood Stream Infections; Skin Diseases, Infectious
    InterventionPolysporin Triple Therapy ointment; Petroleum Jelly
    PhaseNot applicable
    Registry statusWithdrawn

  • Clearance of Nasal Staphylococcus Aureus With Triple Antibiotic Ointment

    NCT00997139 · start 2009-09

    Registered record
    Registry ID
    NCT00997139
    Conditions
    Nasal Carriers of Staphylococcus Aureus
    Interventions
    Neosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2010-11
    Enrolment
    216

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNasal Carriers of Staphylococcus Aureus
    InterventionNeosporin (polymyxin B 5,000units, bacitracin 400 units, neomycin 3.5mg)
    PhaseNot applicable
    Registry statusCompleted

  • Antibiotic Prophylaxis in Children With Pyelonephritis

    NCT00752375 · start 2009-02

    Registered record
    Registry ID
    NCT00752375
    Conditions
    Pyelonephritis
    Interventions
    Trimethoprim Sulfamethoxazole; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2009-02
    Completion
    2014-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPyelonephritis
    InterventionTrimethoprim Sulfamethoxazole; placebo
    PhasePhase 3
    Registry statusWithdrawn

  • Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus Surgery

    NCT00705354 · start 2009-01

    Registered record
    Registry ID
    NCT00705354
    Conditions
    Sinusitis; Chronic Sinusitis
    Interventions
    Bacitracin; Nasopore sponge soaked with saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2009-01
    Completion
    2010-10
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis; Chronic Sinusitis
    InterventionBacitracin; Nasopore sponge soaked with saline
    PhaseNot applicable
    Registry statusWithdrawn

  • Clinical Evaluation of T.R.U.E. TEST® : Safety and Efficacy

    NCT00640614 · start 2008-04

    Registered record
    Registry ID
    NCT00640614
    Conditions
    Contact Dermatitis
    Interventions
    T.R.U.E. TEST® Skin Patch Test: Dose Response Allergens
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-04
    Completion
    2009-10
    Enrolment
    235

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContact Dermatitis
    InterventionT.R.U.E. TEST® Skin Patch Test: Dose Response Allergens
    PhasePhase 3
    Registry statusCompleted

  • Dry Eye and Irritation Comparison of Latanoprost With the Preservative Versus Travoprost Without Preservative

    NCT00803387 · start 2008-04

    Registered record
    Registry ID
    NCT00803387
    Conditions
    Ocular Dryness; Ocular Irritation; Open-Angle Glaucoma; Ocular Hypertension
    Interventions
    Travaprost without BAC (Travatan Z)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-04
    Completion
    2008-09
    Enrolment
    33

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOcular Dryness; Ocular Irritation; Open-Angle Glaucoma; Ocular Hypertension
    InterventionTravaprost without BAC (Travatan Z)
    PhaseNot recorded
    Registry statusCompleted

  • Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage

    NCT00534391 · start 2007-09

    Registered record
    Registry ID
    NCT00534391
    Conditions
    Hordeolum
    Interventions
    neomycin sulfate, polymyxin B sulfate and gramicidin; Artificial tear
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2007-09
    Completion
    2008-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHordeolum
    Interventionneomycin sulfate, polymyxin B sulfate and gramicidin; Artificial tear
    PhasePhase 3
    Registry statusUnknown

  • Effects of Therapy With Sulfamylon® 5% Topical Solution Compared to a Historical Control Group

    NCT00634166 · start 2007-09

    Registered record
    Registry ID
    NCT00634166
    Conditions
    Burns
    Interventions
    Sulfamylon® For 5 % Topical Solution; Topical Antimicrobial/Antifungal Medications
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2007-09
    Completion
    2014-04
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurns
    InterventionSulfamylon® For 5 % Topical Solution; Topical Antimicrobial/Antifungal Medications
    PhasePhase 4
    Registry statusTerminated