Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Remimazolam Besylate

FDA-approved product (powder, intravenous), marketed as Byfavo.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Remimazolam Besylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Sedation

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Benzodiazepine derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA47.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli42.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae25.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis51.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Remimazolam Besylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

-7.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Remimazolam Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery

    NCT07816068 · start 2026-10-01

    Registered record
    Registry ID
    NCT07816068
    Conditions
    Aortic Aneurysm of the Proximal Arch; Aortic Aneurysms Arch; Aortic Arch Disease; Postoperative Delirium (POD); POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE; Postoperative Delirium
    Interventions
    Remimazolam Besylate; propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2027-11-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAortic Aneurysm of the Proximal Arch; Aortic Aneurysms Arch; Aortic Arch Disease; Postoperative Delirium (POD) +2 more
    InterventionRemimazolam Besylate; propofol
    PhasePhase 4
    Registry statusNot yet recruiting

  • Effect of Remimazolam Versus Propofol Total Intravenous Anesthesia on Intraoperative Hemodynamic Stability in Patients Undergoing Thoracic or Abdominal Endovascular Aortic Repair

    NCT07806006 · start 2026-09-15

    Registered record
    Registry ID
    NCT07806006
    Conditions
    Aortic Aneurysm, Thoracoabdominal; Aortic Aneurysm, Abdominal; Intraoperative Hypotension; Hemodynamic Instability During Anesthesia
    Interventions
    Remimazolam Besylate; propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-09-15
    Completion
    2027-10-30
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAortic Aneurysm, Thoracoabdominal; Aortic Aneurysm, Abdominal; Intraoperative Hypotension; Hemodynamic Instability During Anesthesia
    InterventionRemimazolam Besylate; propofol
    PhasePhase 4
    Registry statusNot yet recruiting

  • A Randomized Controlled Trial Comparing the Effects of Different Anesthetic Sedatives on PONV in Laparoscopic Cholecystectomy

    NCT07758803 · start 2026-08-15

    Registered record
    Registry ID
    NCT07758803
    Conditions
    Cholelithiasis; Postoperative Nausea and Vomiting
    Interventions
    Propofol; Ciprofol; Remimazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-08-15
    Completion
    2026-10-30
    Enrolment
    114

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCholelithiasis; Postoperative Nausea and Vomiting
    InterventionPropofol; Ciprofol; Remimazolam
    PhasePhase 4
    Registry statusRecruiting

  • Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy

    NCT07748884 · start 2026-08

    Registered record
    Registry ID
    NCT07748884
    Conditions
    Adverse Respiratory Events; Hypoxemia; Children; Gastroscopy; Esketamine; Remimazolam
    Interventions
    Fentanyl and Propofol; Esketamine and remimazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-08
    Completion
    2026-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdverse Respiratory Events; Hypoxemia; Children; Gastroscopy +2 more
    InterventionFentanyl and Propofol; Esketamine and remimazolam
    PhasePhase 4
    Registry statusNot yet recruiting

  • A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery

    NCT07347496 · start 2026-03-01

    Registered record
    Registry ID
    NCT07347496
    Conditions
    Thoracic Surgery; Anesthesia; Non-intubated Anesthesia
    Interventions
    Remimazolam Besylate for Injection; Propofol; Alfentanil Hydrochloride Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-03-01
    Completion
    2028-05-31
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThoracic Surgery; Anesthesia; Non-intubated Anesthesia
    InterventionRemimazolam Besylate for Injection; Propofol; Alfentanil Hydrochloride Injection
    PhasePhase 4
    Registry statusNot yet recruiting

  • Remimazolam vs Propofol in Laser Burn Cases

    NCT07213544 · start 2025-11-12

    Registered record
    Registry ID
    NCT07213544
    Conditions
    Burn Scar; Hypertrophic Scarring; Procedural Sedation
    Interventions
    Remimazolam besylate; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-11-12
    Completion
    2027-01-01
    Enrolment
    136

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurn Scar; Hypertrophic Scarring; Procedural Sedation
    InterventionRemimazolam besylate; Propofol
    PhasePhase 4
    Registry statusRecruiting

  • REMIMID-ICU: Remimazolam vs Midazolam for Deep Sedation in Hemodynamically Unstable, Mechanically Ventilated Adults

    NCT07155265 · start 2025-10-01

    Registered record
    Registry ID
    NCT07155265
    Conditions
    Critical Illness; Mechanical Ventilation; Shock
    Interventions
    Remimazolam Besylate; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2025-10-01
    Completion
    2027-09-30
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCritical Illness; Mechanical Ventilation; Shock
    InterventionRemimazolam Besylate; Midazolam
    PhasePhase 3
    Registry statusNot yet recruiting

  • Comparative Effects of Remimazolam Tosylate and Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Thoracoscopic Surgery.

    NCT07569614 · start 2025-04-01

    Registered record
    Registry ID
    NCT07569614
    Conditions
    Postoperative Delirium (POD); Thoracoscopic Surgery; Dexmedetomidine; Remimazolam Besylate
    Interventions
    Dexmedetomidine; Remimazolam Besylate; Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-04-01
    Completion
    2026-02-01
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Delirium (POD); Thoracoscopic Surgery; Dexmedetomidine; Remimazolam Besylate
    InterventionDexmedetomidine; Remimazolam Besylate; Normal Saline
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU

    NCT07596589 · start 2025-04-01

    Registered record
    Registry ID
    NCT07596589
    Conditions
    Remimazolam Besylate; Mechanically Ventilated ICU Patients; Sedation
    Interventions
    Remimazolam; propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2025-04-01
    Completion
    2027-01-31
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRemimazolam Besylate; Mechanically Ventilated ICU Patients; Sedation
    InterventionRemimazolam; propofol
    PhasePhase 3
    Registry statusRecruiting

  • Remimazolam Besylate in Sedation of Postcardioperative Patients

    NCT06716840 · start 2025-02-10

    Registered record
    Registry ID
    NCT06716840
    Conditions
    Remimazolam; Propofol; Sedation; Mechanical Ventilation; Intensive Care; Cardiac Surgery
    Interventions
    Remimazolam; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-02-10
    Completion
    2025-05-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRemimazolam; Propofol; Sedation; Mechanical Ventilation +2 more
    InterventionRemimazolam; Propofol
    PhaseNot applicable
    Registry statusRecruiting

  • Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation

    NCT06575530 · start 2025-01-20

    Registered record
    Registry ID
    NCT06575530
    Conditions
    Effect of Drug; Adverse Drug Event; Mechanical Ventilation Complication; Critical Illness; Surgery; Sedation
    Interventions
    Remimazolam Besylate; Dexmedetomidine Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-01-20
    Completion
    2026-06-30
    Enrolment
    306

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEffect of Drug; Adverse Drug Event; Mechanical Ventilation Complication; Critical Illness +2 more
    InterventionRemimazolam Besylate; Dexmedetomidine Hydrochloride
    PhasePhase 4
    Registry statusRecruiting

  • The Efficacy and Safety of Remimazolam Besylate for Cardiac Anesthesia

    NCT06717945 · start 2025-01

    Registered record
    Registry ID
    NCT06717945
    Conditions
    Anesthesia
    Interventions
    remimazolam besylate; propofol
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Not yet recruiting
    Start
    2025-01
    Completion
    2025-06
    Enrolment
    320

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia
    Interventionremimazolam besylate; propofol
    PhaseEarly phase 1
    Registry statusNot yet recruiting

  • Comparison of Efficacy and Safety Between Ciprofol and Remimazolam During Fiberoptic Bronchoscopy

    NCT06531915 · start 2024-12-01

    Registered record
    Registry ID
    NCT06531915
    Conditions
    Fiberoptic Bronchoscopy
    Interventions
    Ciprofol; Remimazolam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-12-01
    Completion
    2025-03-31
    Enrolment
    190

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFiberoptic Bronchoscopy
    InterventionCiprofol; Remimazolam
    PhaseNot applicable
    Registry statusUnknown

  • Remimazolam Versus Midazolam for Sedation During Upper GI Endoscopy: a Randomized Controlled Trial

    NCT06614036 · start 2024-10-21

    Registered record
    Registry ID
    NCT06614036
    Conditions
    Sedation for Diagnostic Gastroscopy
    Interventions
    Remimazolam; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2024-10-21
    Completion
    2026-04-30
    Enrolment
    148

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSedation for Diagnostic Gastroscopy
    InterventionRemimazolam; Midazolam
    PhasePhase 4
    Registry statusRecruiting

  • Postoperative Quality of Recovery After General Anesthesia With Remimazolam

    NCT06332157 · start 2024-09

    Registered record
    Registry ID
    NCT06332157
    Conditions
    Anesthesia Recovery Period
    Interventions
    Remimazolam besylate; Propofol Injection Emulsion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-09
    Completion
    2025-12
    Enrolment
    126

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia Recovery Period
    InterventionRemimazolam besylate; Propofol Injection Emulsion
    PhaseNot applicable
    Registry statusUnknown