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AMR Drug RepurposingSmart Screeningresearch prototype

Remimazolam Besylate

FDA-approved product (powder, intravenous), marketed as Byfavo.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Remimazolam Besylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Sedation

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Benzodiazepine derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA47.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli42.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae25.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis51.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Remimazolam Besylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

-7.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Remimazolam Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • The Effect of Wavelet Index in Monitoring the Sedation Depth of Remimazolam Besylate

    NCT06427785 · start 2024-08-15

    Registered record
    Registry ID
    NCT06427785
    Conditions
    Remimazolam; Anesthesia Awareness; Sedative, Hypnotic, or Anxiolytic Withdrawal
    Interventions
    Remimazolam besylate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2024-08-15
    Completion
    2025-08-15
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRemimazolam; Anesthesia Awareness; Sedative, Hypnotic, or Anxiolytic Withdrawal
    InterventionRemimazolam besylate
    PhaseNot recorded
    Registry statusUnknown

  • Remimazolam Besylate and Propofol Sedation on Hemodynamic for Coronary Artery Bypass Graft Patients

    NCT06496165 · start 2024-07-15

    Registered record
    Registry ID
    NCT06496165
    Conditions
    Coronary Artery Disease
    Interventions
    Remimazolam; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2024-07-15
    Completion
    2026-12-31
    Enrolment
    338

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease
    InterventionRemimazolam; Propofol
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Paradoxical Reactions of Remimazolam in Pediatric Painless Gastrointestinal Endoscopy

    NCT06419543 · start 2024-05-20

    Registered record
    Registry ID
    NCT06419543
    Conditions
    Endoscopy, Gastrointestinal
    Interventions
    Remimazolam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-05-20
    Completion
    2024-10-01
    Enrolment
    333

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndoscopy, Gastrointestinal
    InterventionRemimazolam
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Remimazolam and Propofol Combination vs. Propofol in IOM

    NCT06382467 · start 2024-05

    Registered record
    Registry ID
    NCT06382467
    Conditions
    Neurologic Disorder
    Interventions
    Remimazolam besylate + propofol MCT; Propofol MCT
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2024-05
    Completion
    2025-06
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeurologic Disorder
    InterventionRemimazolam besylate + propofol MCT; Propofol MCT
    PhasePhase 4
    Registry statusUnknown

  • ED90 of Remimazolam Anesthesia Induction in Drug-induced Sleep Endoscopy in Adults

    NCT06333145 · start 2024-02-04

    Registered record
    Registry ID
    NCT06333145
    Conditions
    Effect of Drug
    Interventions
    Remimazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2024-02-04
    Completion
    2026-06-20
    Enrolment
    165

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEffect of Drug
    InterventionRemimazolam
    PhasePhase 4
    Registry statusCompleted

  • ED90 of Remimazolam Anesthesia Induction in Painless Bidirectional Endoscopy in Children

    NCT06121609 · start 2024-01-15

    Registered record
    Registry ID
    NCT06121609
    Conditions
    Bidirectional Endoscopy
    Interventions
    Remimazolam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-01-15
    Completion
    2024-04-30
    Enrolment
    165

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBidirectional Endoscopy
    InterventionRemimazolam
    PhaseNot applicable
    Registry statusCompleted

  • Sedative Effect and Safety of Remimazolam Besylate in ARDS Patients

    NCT05758597 · start 2024-01-02

    Registered record
    Registry ID
    NCT05758597
    Conditions
    Respiratory Distress Syndrome
    Interventions
    Remazolam besylate; midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2024-01-02
    Completion
    2025-06-16
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Distress Syndrome
    InterventionRemazolam besylate; midazolam
    PhasePhase 4
    Registry statusUnknown

  • Dose of Remimazolam in Children for Intubation

    NCT06170918 · start 2023-12-20

    Registered record
    Registry ID
    NCT06170918
    Conditions
    Anesthesia
    Interventions
    Remimazolam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-12-20
    Completion
    2024-05-31
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia
    InterventionRemimazolam
    PhaseNot applicable
    Registry statusUnknown

  • Dose Finding Study for Remimazolam in Children

    NCT05975255 · start 2023-11-16

    Registered record
    Registry ID
    NCT05975255
    Conditions
    Drug Effect
    Interventions
    Remimazolam besylate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2023-11-16
    Completion
    2024-12-31
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Effect
    InterventionRemimazolam besylate
    PhasePhase 2
    Registry statusUnknown

  • PK/PD Properties and Safety of Remazolam Besylate for Injection in ICU Patients With Impaired Renal Function

    NCT06153498 · start 2023-11-04

    Registered record
    Registry ID
    NCT06153498
    Conditions
    Mechanically Ventilated Patients
    Interventions
    Remimazolam besylate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-11-04
    Completion
    2024-12-13
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMechanically Ventilated Patients
    InterventionRemimazolam besylate
    PhaseNot applicable
    Registry statusCompleted

  • The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction

    NCT06061159 · start 2023-10-06

    Registered record
    Registry ID
    NCT06061159
    Conditions
    Pediatric; ED95; Sedation; General Anesthesia
    Interventions
    Remimazolam besylate; Remimazolam besylate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-10-06
    Completion
    2024-02-27
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPediatric; ED95; Sedation; General Anesthesia
    InterventionRemimazolam besylate; Remimazolam besylate
    PhasePhase 4
    Registry statusCompleted

  • Effect of Remimazolam on the Recovery Quality After Day Surgery

    NCT05748665 · start 2023-08-14

    Registered record
    Registry ID
    NCT05748665
    Conditions
    Elderly Patients; Ambulatory Surgery
    Interventions
    Remimazolam besylate; etomidate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-08-14
    Completion
    2024-01-26
    Enrolment
    118

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionElderly Patients; Ambulatory Surgery
    InterventionRemimazolam besylate; etomidate
    PhaseNot applicable
    Registry statusCompleted

  • The Dose Range of Remimazolam Besylate in Different Age Groups

    NCT06009991 · start 2023-07-17

    Registered record
    Registry ID
    NCT06009991
    Conditions
    Remimazolam; Anesthesia
    Interventions
    Remimazolam besylate; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-07-17
    Completion
    2025-12-31
    Enrolment
    1,876

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRemimazolam; Anesthesia
    InterventionRemimazolam besylate; Propofol
    PhaseNot applicable
    Registry statusUnknown

  • Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR

    NCT05864625 · start 2023-06-29

    Registered record
    Registry ID
    NCT05864625
    Conditions
    Aortic Valve Stenosis; Remimazolam
    Interventions
    Remimazolam besylate; Propofol/ Sevoflurane
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-06-29
    Completion
    2025-06-10
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAortic Valve Stenosis; Remimazolam
    InterventionRemimazolam besylate; Propofol/ Sevoflurane
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Remimazolam and Midazolam for Preventing Intraoperative Nausea and Vomiting During Cesarean Section Under Spinal Anesthesia

    NCT05736341 · start 2023-05-17

    Registered record
    Registry ID
    NCT05736341
    Conditions
    Pregnancy; Cesarean Section; Spinal Anesthesia
    Interventions
    Remimazolam besylate; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-05-17
    Completion
    2024-01-06
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy; Cesarean Section; Spinal Anesthesia
    InterventionRemimazolam besylate; Midazolam
    PhaseNot applicable
    Registry statusCompleted