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AMR Drug RepurposingSmart Screeningresearch prototype

Midazolam

FDA-approved product (spray, nasal), marketed as Midazolam In 0.8% Sodium Chloride, Midazolam In 0.9% Sodium Chloride, Nayzilam and 6 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Midazolam
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Amnesia
  • Epilepsy
  • Seizure
  • Status epilepticus

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Benzodiazepine derivatives
FDA pharmacologic class
Benzodiazepine FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae18.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis64.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Midazolam in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Midazolam with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Virtual Reality Distraction Technique for Anxiety and Pain Control in Orthopedic Forearm Surgeries Performed Under Supraclavicular Brachial Plexus Block

    NCT05512728 · start 2020-12-20

    Registered record
    Registry ID
    NCT05512728
    Conditions
    Anesthesia
    Interventions
    VR; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-12-20
    Completion
    2022-12-20
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia
    InterventionVR; Midazolam
    PhaseNot applicable
    Registry statusUnknown

  • Comparison and Outcomes of Endoscopic Ultrasound Liver Biopsies Versus Percutaneous Liver Biopsies

    NCT04751045 · start 2020-10-25

    Registered record
    Registry ID
    NCT04751045
    Conditions
    Chronic Liver Disease
    Interventions
    EUS liver biopsy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-10-25
    Completion
    2021-10-01
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Liver Disease
    InterventionEUS liver biopsy
    PhaseNot applicable
    Registry statusCompleted

  • A Study of LY3509754 in Healthy Non-Japanese and Japanese Participants

    NCT04586920 · start 2020-10-20

    Registered record
    Registry ID
    NCT04586920
    Conditions
    Healthy
    Interventions
    LY3509754; Placebo; Itraconazole; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2020-10-20
    Completion
    2022-10-14
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionLY3509754; Placebo; Itraconazole; Midazolam
    PhasePhase 1
    Registry statusTerminated

  • Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes

    NCT04504045 · start 2020-09-01

    Registered record
    Registry ID
    NCT04504045
    Conditions
    Diabetes Mellitus, Type 2
    Interventions
    Metformin; Caffeine; Efavirenz; Losartan; Omeprazol; Metoprolol; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2020-09-01
    Completion
    2022-05-10
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus, Type 2
    InterventionMetformin; Caffeine; Efavirenz; Losartan +3 more
    PhasePhase 1
    Registry statusTerminated

  • Drug-Drug Interaction Study Between EDP-938, Tacrolimus, Dabigatran, Rosuvastatin and Midazolam in Healthy Subjects

    NCT04498741 · start 2020-07-08

    Registered record
    Registry ID
    NCT04498741
    Conditions
    RSV Infection
    Interventions
    EDP-938; EDP-938; EDP-938; Tacrolimus; Dabigatran; Rosuvastatin; EDP-938; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2020-07-08
    Completion
    2021-06-01
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRSV Infection
    InterventionEDP-938; EDP-938; EDP-938; Tacrolimus +4 more
    PhasePhase 1
    Registry statusCompleted

  • A Study to Test How Well Healthy Men Tolerate Different Doses of BI 764198

    NCT04102462 · start 2019-10-29

    Registered record
    Registry ID
    NCT04102462
    Conditions
    Healthy
    Interventions
    BI 764198; Matching placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-10-29
    Completion
    2020-10-08
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionBI 764198; Matching placebo
    PhasePhase 1
    Registry statusCompleted

  • Does Midazolam Cause Effective Anterograde Amnesia in Orthopedic Surgeries?

    NCT04232150 · start 2019-06-01

    Registered record
    Registry ID
    NCT04232150
    Conditions
    Anesthesia; Orthopedic Surgery
    Interventions
    single-dose midazolam for sedation under spinal anesthesia.; Double-dose midazolam for sedation under spinal anesthesia.; spinal anesthesia with no sedation.
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-06-01
    Completion
    2019-11-01
    Enrolment
    116

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Orthopedic Surgery
    Interventionsingle-dose midazolam for sedation under spinal anesthesia.; Double-dose midazolam for sedation under spinal anesthesia.; spinal anesthesia with no sedation.
    PhaseNot applicable
    Registry statusCompleted

  • IN Ketamine vs IN Midazolam and Fentanyl for Laceration Repair

    NCT03528512 · start 2018-09-04

    Registered record
    Registry ID
    NCT03528512
    Conditions
    Laceration of Skin
    Interventions
    Ketamine; Midazolam and fentanyl
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2018-09-04
    Completion
    2019-02-06
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaceration of Skin
    InterventionKetamine; Midazolam and fentanyl
    PhasePhase 4
    Registry statusTerminated

  • Colonic Motor Patterns in Healthy Volunteers

    NCT05770960 · start 2018-06-27

    Registered record
    Registry ID
    NCT05770960
    Conditions
    Opioid-Induced Constipation
    Interventions
    Naloxegol; codeine phosphate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-06-27
    Completion
    2019-05-09
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid-Induced Constipation
    InterventionNaloxegol; codeine phosphate; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Assessing Goldenseal-drug Interactions Using a Probe Drug Cocktail Approach

    NCT03772262 · start 2018-04-05

    Registered record
    Registry ID
    NCT03772262
    Conditions
    Interaction Drug Food
    Interventions
    goldenseal; Metformin; Furosemide; Midazolam oral solution; Rosuvastatin Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2018-04-05
    Completion
    2019-03-31
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInteraction Drug Food
    Interventiongoldenseal; Metformin; Furosemide; Midazolam oral solution +1 more
    PhaseEarly phase 1
    Registry statusCompleted

  • Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate Cancer

    NCT03436485 · start 2018-03-19

    Registered record
    Registry ID
    NCT03436485
    Conditions
    Prostate Cancer Metastatic
    Interventions
    ODM-208; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Active not recruiting
    Start
    2018-03-19
    Completion
    2026-10-31
    Enrolment
    204

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer Metastatic
    InterventionODM-208; Midazolam
    PhasePhase 1 / Phase 2
    Registry statusActive not recruiting

  • Effects of Dexmedetomidine vs Midazolam on Microcirculation in Septic Shock Patients

    NCT03434691 · start 2018-02-08

    Registered record
    Registry ID
    NCT03434691
    Conditions
    Septic Shock
    Interventions
    Microdialysis Probe (Muscle microdialysis); remifentanyl
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-02-08
    Completion
    2018-12-31
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeptic Shock
    InterventionMicrodialysis Probe (Muscle microdialysis); remifentanyl
    PhaseNot applicable
    Registry statusUnknown

  • Drug-drug Interaction Study Between Orally Administered Rifampicin and Vilaprisan

    NCT02975440 · start 2016-11-10

    Registered record
    Registry ID
    NCT02975440
    Conditions
    Endometriosis
    Interventions
    Rifampicin; Midazolam; BAY1002670_Vilaprisan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-11-10
    Completion
    2017-04-11
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometriosis
    InterventionRifampicin; Midazolam; BAY1002670_Vilaprisan
    PhasePhase 1
    Registry statusCompleted

  • Oral Dexmedetomidine vs Midazoam For Premedication

    NCT03357718 · start 2016-11-01

    Registered record
    Registry ID
    NCT03357718
    Conditions
    Premedication
    Interventions
    Precedex; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-11-01
    Completion
    2017-06-01
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPremedication
    InterventionPrecedex; Midazolam
    PhasePhase 4
    Registry statusCompleted

  • MetAbolism vaRiability of VEnLafaxine

    NCT02590185 · start 2015-12

    Registered record
    Registry ID
    NCT02590185
    Conditions
    Major Depressive Disorders
    Interventions
    cocktail probe drugs
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2015-12
    Completion
    2020-04
    Enrolment
    205

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorders
    Interventioncocktail probe drugs
    PhaseNot applicable
    Registry statusUnknown