Ergoloid Mesylates
FDA-approved product (tablet, sublingual), marketed as Alkergot, Circanol, Deapril-St and 5 more.
- Registered studies
- 2
- Lab records
- 0
- Pathogens at ≥40%
- 4 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Cardiovascular disease
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Ergot alkaloids
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA57.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli54.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae47.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- M. tuberculosis61.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
2registered studies name this medicine, for any condition. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Ergoloid Mesylates with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- GrazoprevirExisting use: Chronic hepatitis C virus infection44.6% AI-predicted activityagainst K. pneumoniae50+ registered studies
- TacrolimusExisting use: Atopic eczema, Delayed Graft Function, Eczematoid dermatitis and 3 more44.4% AI-predicted activityagainst K. pneumoniae50+ registered studies
- Prasugrel HydrochlorideExisting use: Acute coronary syndrome, Hemorrhage, Intermediate coronary syndrome and 1 more44.4% AI-predicted activityagainst K. pneumoniae50+ registered studies
- PosaconazoleExisting use: Aspergillosis, Candidiasis, Coccidioidomycosis and 2 more44.0% AI-predicted activityagainst K. pneumoniae50+ registered studies
- Baloxavir MarboxilExisting use: Influenza, Viral disease44.0% AI-predicted activityagainst K. pneumoniae24 registered studies
- RivaroxabanExisting use: Acute coronary syndrome, Atrial fibrillation, Coronary artery disease and 9 more43.6% AI-predicted activityagainst K. pneumoniae50+ registered studies
- LevoleucovorinExisting use: Anemia, Colorectal adenocarcinoma, Colorectal cancer and 3 more43.6% AI-predicted activityagainst K. pneumoniae50+ registered studies
- Leucovorin CalciumExisting use: Osteosarcoma43.6% AI-predicted activityagainst K. pneumoniae50+ registered studies
- PaliperidoneExisting use: Mental or behavioural disorder, Psychosis, Schizoaffective disorder and 1 more43.4% AI-predicted activityagainst K. pneumoniae50+ registered studies
- RisperidoneExisting use: Aggressive behavior, Autism, Bipolar disorder and 4 more43.3% AI-predicted activityagainst K. pneumoniae50+ registered studies
- SirolimusExisting use: Adenoma sebaceum, Angiofibroma, Cancer and 5 more43.1% AI-predicted activityagainst K. pneumoniae50+ registered studies
- Pipecuronium BromideExisting use: Other quaternary ammonium compounds42.9% AI-predicted activityagainst K. pneumoniae5 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
ERG/5-HTP in Fragile X Syndrome (FXS)
NCT05030129 · start 2021-10-07
Registered record
- Registry ID
- NCT05030129
- Conditions
- Fragile X Syndrome
- Interventions
- 5-Hydroxytryptophan; Ergoloid Mesylates; Matching placebo for Ergoloid mesylates; Matching placebo for 5-Hydroxytryptophan
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2021-10-07
- Completion
- 2023-01-19
- Enrolment
- 15
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionFragile X SyndromeIntervention5-Hydroxytryptophan; Ergoloid Mesylates; Matching placebo for Ergoloid mesylates; Matching placebo for 5-HydroxytryptophanPhasePhase 2Registry statusCompletedStudy of STA-1 Capsule in Patients With Vascular Dementia (Marrow-Sea Deficiency)
NCT01475578 · start 2002-03
Registered record
- Registry ID
- NCT01475578
- Conditions
- Vascular Dementia
- Interventions
- STA-1; Ergoloid Mesylates tablet
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2002-03
- Completion
- 2002-10
- Enrolment
- 240
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionVascular DementiaInterventionSTA-1; Ergoloid Mesylates tabletPhasePhase 2Registry statusCompleted