Alclometasone Dipropionate
FDA-approved product (ointment, topical), marketed as Aclovate, Alclometasone Dipropionate.
- Registered studies
- 2
- Lab records
- 0
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Eye inflammation
- Skin disease
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Corticosteroids, moderately potent (group ii); Corticosteroids, plain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA50.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli47.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae36.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis47.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
2registered studies name this medicine, for any condition. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Alclometasone Dipropionate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Setmelanotide AcetateExisting use: Obesity61.5% AI-predicted activityagainst MRSANo documented evidence found
- Dolutegravir SodiumExisting use: HIV infection, HIV-1 infection61.4% AI-predicted activityagainst MRSA50+ registered studies
- ItraconazoleExisting use: Aspergillosis, Blastomycosis, Candidiasis and 4 more61.2% AI-predicted activityagainst MRSA50+ registered studies
- SelpercatinibExisting use: Cancer, Medullary thyroid gland carcinoma, Neoplasm and 4 more61.2% AI-predicted activityagainst MRSA42 registered studies
- Obeticholic AcidExisting use: Biliary liver cirrhosis, Cholangitis, Primary biliary cirrhosis60.9% AI-predicted activityagainst MRSA44 registered studies
- TolvaptanExisting use: Autosomal dominant polycystic kidney disease, Cardiovascular disease, Congestive heart failure and 4 more60.8% AI-predicted activityagainst MRSA50+ registered studies
- Chlorhexidine GluconateExisting use: Eye infection, Gingivitis, Infection and 2 more60.8% AI-predicted activityagainst MRSALab records exist50+ registered studies
- CiclesonideExisting use: Airway obstruction, Allergic rhinitis, Asthma and 3 more60.7% AI-predicted activityagainst MRSA50+ registered studies
- IloperidoneExisting use: Psychosis, Schizophrenia60.6% AI-predicted activityagainst MRSA32 registered studies
- Ponatinib HydrochlorideExisting use: Acute lymphoblastic leukemia, Chronic myelogenous leukemia, Lymphoid leukemia and 1 more60.6% AI-predicted activityagainst MRSA50+ registered studies
- VoclosporinExisting use: Immune system disease, Lupus nephritis60.6% AI-predicted activityagainst MRSA28 registered studies
- Doxazosin MesylateExisting use: Benign prostatic hyperplasia, Hypertension, Myocardial infarction60.6% AI-predicted activityagainst MRSA50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO
NCT01465802 · start 2011-12-26
Registered record
- Registry ID
- NCT01465802
- Conditions
- Non Small Cell Lung Cancer (NSCLC)
- Interventions
- Dacomitinib; Dacomitinib; Doxycycline; Probiotic; Alclometasone cream
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2011-12-26
- Completion
- 2015-05-18
- Enrolment
- 236
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionNon Small Cell Lung Cancer (NSCLC)InterventionDacomitinib; Dacomitinib; Doxycycline; Probiotic +1 morePhasePhase 2Registry statusCompletedStudy to Evaluate Product Duration of Use Experience With Alclometasone Dipropionate Cream
NCT02075632 · start 2006-09
Registered record
- Registry ID
- NCT02075632
- Conditions
- Eczema; Allergy Symptoms; Psoriasis; Itch
- Interventions
- Alclometasone dipropionate cream
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2006-09
- Completion
- 2006-11
- Enrolment
- 310
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionEczema; Allergy Symptoms; Psoriasis; ItchInterventionAlclometasone dipropionate creamPhasePhase 2Registry statusCompleted