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AMR Drug RepurposingSmart Screeningresearch prototype

Meropenem

FDA-approved product (injectable, injection), marketed as Meropenem, Meropenem And Sodium Chloride In Duplex Container, Merrem Iv.

Registered studies
50+
Lab records
263
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Meropenem
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Bacterial meningitis
  • Bacteriemia
  • Infection
  • Infectious meningitis
  • Meningitis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Carbapenems
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DH02

Repurposing investigation

Meropenem is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA96.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli99.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae98.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis42.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 16 of 17 lab records
  • E. coli: measured active in 38 of 38 lab records
  • K. pneumoniae: measured active in 172 of 208 lab records
Open Meropenem in ChEMBL Registered studies below
Show the latest 150 of 263 laboratory records, with sources

Loading records…

Every record is in ChEMBL, linked above. “Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Meropenem with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Target Attainment and Pharmacokinetics of Antimicrobials in Non-critically Ill Surgery Patients (TAPAS)

    NCT03120663 · start 2016-11-30

    Registered record
    Registry ID
    NCT03120663
    Conditions
    Surgery
    Interventions
    amoxicillin-clavulanic acid
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2016-11-30
    Completion
    2018-09-30
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgery
    Interventionamoxicillin-clavulanic acid
    PhaseNot recorded
    Registry statusUnknown

  • Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections

    NCT02784704 · start 2016-10-13

    Registered record
    Registry ID
    NCT02784704
    Conditions
    Complicated Intra-abdominal Infections; Complicated Appendicitis
    Interventions
    Eravacycline; Meropenem; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-10-13
    Completion
    2017-05-19
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplicated Intra-abdominal Infections; Complicated Appendicitis
    InterventionEravacycline; Meropenem; Placebo
    PhasePhase 3
    Registry statusCompleted

  • The Effect of Colistin Inhalation on Ventilator Associated Pneumonia

    NCT03622450 · start 2016-01-02

    Registered record
    Registry ID
    NCT03622450
    Conditions
    Ventilator Associated Pneumonia
    Interventions
    Colistin; Carbapenem + Aminoglycoside/ Quinolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2016-01-02
    Completion
    2018-01-10
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentilator Associated Pneumonia
    InterventionColistin; Carbapenem + Aminoglycoside/ Quinolone
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Evaluation of Safety,Pharmacokinetics and Efficacy of CAZ-AVI With Metronidazole in Children Aged 3 Months to 18 Years Old With Complicated Intra-abdominal Infections (cIAIs).

    NCT02475733 · start 2015-08-01

    Registered record
    Registry ID
    NCT02475733
    Conditions
    Complicated Intra-abdominal Infections
    Interventions
    Ceftazidime -avibactam; Meropenem; Metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-08-01
    Completion
    2017-06-01
    Enrolment
    83

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplicated Intra-abdominal Infections
    InterventionCeftazidime -avibactam; Meropenem; Metronidazole
    PhasePhase 2
    Registry statusCompleted

  • Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO

    NCT02149329 · start 2014-12

    Registered record
    Registry ID
    NCT02149329
    Conditions
    Febrile Neutropenia; Hematological Malignancy
    Interventions
    Discontinuation of imipenem-cilastatin or meropenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-12
    Completion
    2019-08-05
    Enrolment
    276

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFebrile Neutropenia; Hematological Malignancy
    InterventionDiscontinuation of imipenem-cilastatin or meropenem
    PhasePhase 4
    Registry statusCompleted

  • Meropenem and Ciprofloxacin Dosing in Septic Shock

    NCT02240277 · start 2014-11

    Registered record
    Registry ID
    NCT02240277
    Conditions
    Septic Shock
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2014-11
    Completion
    2016-03
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeptic Shock
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)

    NCT01970371 · start 2014-09-16

    Registered record
    Registry ID
    NCT01970371
    Conditions
    Bloodstream Infections (BSI) Due to CRE; Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE; Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE; Complicated Urinary Tract Infection (cUTI) Due to CRE; Acute Pyelonephritis (AP) Due to CRE
    Interventions
    plazomicin; colistin; meropenem; tigecycline; antibiotic of Investigator's choice
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-09-16
    Completion
    2016-09-15
    Enrolment
    69

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBloodstream Infections (BSI) Due to CRE; Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE; Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE; Complicated Urinary Tract Infection (cUTI) Due to CRE +1 more
    Interventionplazomicin; colistin; meropenem; tigecycline +1 more
    PhasePhase 3
    Registry statusCompleted

  • Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008)

    NCT02070757 · start 2014-09-02

    Registered record
    Registry ID
    NCT02070757
    Conditions
    Healthcare-Associated Pneumonia; Ventilator-Associated Pneumonia; Lung Diseases
    Interventions
    Ceftolozane/tazobactam; Meropenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-09-02
    Completion
    2018-06-06
    Enrolment
    726

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthcare-Associated Pneumonia; Ventilator-Associated Pneumonia; Lung Diseases
    InterventionCeftolozane/tazobactam; Meropenem
    PhasePhase 3
    Registry statusCompleted

  • Pharmacokinetics of Intraperitoneal and Intravenous Meropenem, Ampicillin, Aztreonam and Ciprofloxacin in Automated Peritoneal Dialysis Patients Without Peritonitis

    NCT07113587 · start 2014-04-08

    Registered record
    Registry ID
    NCT07113587
    Conditions
    Peritoneal Dialysis-associated Peritonitis; Peritoneal Dialysis (PD); Pharmacokinetics; Intravenous Administration; Intravenous; Meropenem; Intraperitoneal; Ampicillin; Aztreonam; Ciprofloxacin; Minimum Inhibitory Concentration (MIC)
    Interventions
    Application of intraperitoneal and intravenous meropenem in in automated peritoneal dialysis patients without peritonitis; Application of intraperitoneal and intravenous ampicillin in automated peritoneal dialysis patients without peritonitis; Application of intraperitoneal and intravenous aztreonam in automated peritoneal dialysis patients without peritonitis; Application of intraperitoneal and intravenous ciprofloxacin in automated peritoneal dialysis patients without peritonitis
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2014-04-08
    Completion
    2017-07-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeritoneal Dialysis-associated Peritonitis; Peritoneal Dialysis (PD); Pharmacokinetics; Intravenous Administration +7 more
    InterventionApplication of intraperitoneal and intravenous meropenem in in automated peritoneal dialysis patients without peritonitis; Application of intraperitoneal and intravenous ampicillin in automated peritoneal dialysis patients without peritonitis; Application of intraperitoneal and intravenous aztreonam in automated peritoneal dialysis patients without peritonitis; Application of intraperitoneal and intravenous ciprofloxacin in automated peritoneal dialysis patients without peritonitis
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Intermittent Versus Continuous Infusion Meropenem in Cystic Fibrosis

    NCT02048163 · start 2013-12

    Registered record
    Registry ID
    NCT02048163
    Conditions
    Cystic Fibrosis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Withdrawn
    Start
    2013-12
    Completion
    2015-08
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystic Fibrosis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusWithdrawn

  • Pharmacokinetics of Selected Antiinfectives During Sustained Low-efficiency Dialysis (SLED)

    NCT02287493 · start 2013-07

    Registered record
    Registry ID
    NCT02287493
    Conditions
    Replacement Therapy, Renal
    Interventions
    Pharmacokinetic Analysis
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-07
    Completion
    2016-12
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionReplacement Therapy, Renal
    InterventionPharmacokinetic Analysis
    PhaseNot recorded
    Registry statusCompleted

  • Multicenter Open-label Randomized Controlled Trial (RCT) to Compare Colistin Alone Versus Colistin Plus Meropenem

    NCT01732250 · start 2013-03

    Registered record
    Registry ID
    NCT01732250
    Conditions
    Gram-Negative Bacterial Infections
    Interventions
    Colistin; Meropenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-03
    Completion
    2017-02-28
    Enrolment
    406

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGram-Negative Bacterial Infections
    InterventionColistin; Meropenem
    PhasePhase 4
    Registry statusCompleted

  • A Comparative Study of ID Fellow-based VS. Pharmacist-based Antibiotic Pre-authorization

    NCT01797133 · start 2013-02

    Registered record
    Registry ID
    NCT01797133
    Conditions
    All Hospitalzied Patients; No Specific Conditions Requires
    Interventions
    ID fellow-based antibiotic pre-authorization; Pharmacist-based antibiotic pre-authorization
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-02
    Completion
    2013-12
    Enrolment
    984

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAll Hospitalzied Patients; No Specific Conditions Requires
    InterventionID fellow-based antibiotic pre-authorization; Pharmacist-based antibiotic pre-authorization
    PhaseNot applicable
    Registry statusCompleted

  • Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis

    NCT01992198 · start 2012-07

    Registered record
    Registry ID
    NCT01992198
    Conditions
    Pancreatitis,Acute Necrotizing
    Interventions
    cefoperazone + metronidazole; oral care by chlorhexidine gluconate; enteral nutrition; Somatostatin; Meropenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-07
    Completion
    2016-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPancreatitis,Acute Necrotizing
    Interventioncefoperazone + metronidazole; oral care by chlorhexidine gluconate; enteral nutrition; Somatostatin +1 more
    PhasePhase 4
    Registry statusUnknown

  • Compare Ceftazidime-Avibactam + Metronidazole Versus Meropenem for Hospitalized Adults With Complicated Intra-Abdominal Infections

    NCT01499290 · start 2012-03

    Registered record
    Registry ID
    NCT01499290
    Conditions
    Complicated Intra-Abdominal Infection
    Interventions
    CAZ-AVI; Metronidazole; Meropenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-03
    Completion
    2014-04
    Enrolment
    493

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplicated Intra-Abdominal Infection
    InterventionCAZ-AVI; Metronidazole; Meropenem
    PhasePhase 3
    Registry statusCompleted