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AMR Drug RepurposingSmart Screeningresearch prototype

Tamsulosin Hydrochloride

FDA-approved product (capsule, oral), marketed as Flomax, Tamsulosin Hydrochloride.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Tamsulosin Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Benign prostatic hyperplasia
  • Prostate carcinoma

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Alpha-adrenoreceptor antagonists
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA28.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli31.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae21.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis73.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Tamsulosin Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tamsulosin Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Preoperative Alpha-blockers on Successful Insertion Ureteral Access Sheath and Reduce Ureteral Injury in Non-prestented Patients During RIRS. Assessment of Factors for Successful Ureteral Access Sheath Insertion.

    NCT07202923 · start 2021-07-09

    Registered record
    Registry ID
    NCT07202923
    Conditions
    Urolithiasis; Ureteral Injury; Ureteral Access Sheath; Retrograde Intrarenal Surgery
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-07-09
    Completion
    2024-06-02
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrolithiasis; Ureteral Injury; Ureteral Access Sheath; Retrograde Intrarenal Surgery
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Efficacy of Antihistamine Drugs as Medical Expulsive Therapy Alone or in Combination With Alpha Blockers: A Prospective Randomized Controlled Study

    NCT06754410 · start 2021-03-01

    Registered record
    Registry ID
    NCT06754410
    Conditions
    Lower Ureteric Stones
    Interventions
    Tamsulosin; Cetirizine; Cetirizine + Tamsulosin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2021-03-01
    Completion
    2024-03-01
    Enrolment
    480

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLower Ureteric Stones
    InterventionTamsulosin; Cetirizine; Cetirizine + Tamsulosin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • The Efficacy and Safety of Medical Expulsive Therapy After Extracorporeal Shock Wave Lithotripsy (ESWL) in Pediatric Urolithiasis

    NCT05759767 · start 2021-02-01

    Registered record
    Registry ID
    NCT05759767
    Conditions
    Tamsulosin; Extracorporeal Shock Wave Lithotripsy; Stone, Kidney; Stone, Urinary; Pediatric Disorder
    Interventions
    Tamsulosin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-02-01
    Completion
    2023-12-01
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTamsulosin; Extracorporeal Shock Wave Lithotripsy; Stone, Kidney; Stone, Urinary +1 more
    InterventionTamsulosin; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Comparison Between Tamsulosin and Tadalafil in Management of Benign Prostatic Hyperplasia Long Term Study

    NCT05818670 · start 2020-11-11

    Registered record
    Registry ID
    NCT05818670
    Conditions
    BPH
    Interventions
    Tamsulosin; Tadalafil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-11-11
    Completion
    2022-09-17
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBPH
    InterventionTamsulosin; Tadalafil
    PhasePhase 4
    Registry statusCompleted

  • Herbal Supplement Prosta-OK® Neo as an Adjunct Therapy in Patients With Mild to Severe Non-neurogenic Male Lower Urinary Tract Symptoms Receiving Tamsulosin Therapy

    NCT04418635 · start 2020-06-04

    Registered record
    Registry ID
    NCT04418635
    Conditions
    Lower Urinary Tract Symptoms
    Interventions
    Prosta-OK® Neo or Prosta-OK® Neo-matched placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-06-04
    Completion
    2021-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLower Urinary Tract Symptoms
    InterventionProsta-OK® Neo or Prosta-OK® Neo-matched placebo
    PhaseNot applicable
    Registry statusUnknown

  • Medical Expulsive Therapy Post-SWL For Renal Stones

    NCT05032287 · start 2019-09-01

    Registered record
    Registry ID
    NCT05032287
    Conditions
    Urologic Diseases; Urolithiasis; Stone, Kidney
    Interventions
    Tamsulosin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-09-01
    Completion
    2020-05-01
    Enrolment
    235

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrologic Diseases; Urolithiasis; Stone, Kidney
    InterventionTamsulosin; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Pre-induction Analgesia: Multimodel Regimen vs Aceteminophen for Post Ureteroscopy Pain

    NCT03549611 · start 2018-08-01

    Registered record
    Registry ID
    NCT03549611
    Conditions
    Kidney Calculi; Pain, Postoperative
    Interventions
    Multimodal Oral Drug Regimen; Acetaminophen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2018-08-01
    Completion
    2019-06-30
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Calculi; Pain, Postoperative
    InterventionMultimodal Oral Drug Regimen; Acetaminophen
    PhasePhase 4
    Registry statusWithdrawn

  • Mirabegron for Treatment of Erectile Dysfunction in Patients With LUTS Secondry to BPH: A Randomized Study

    NCT03600766 · start 2018-08-01

    Registered record
    Registry ID
    NCT03600766
    Conditions
    BPH; Erectile Dysfunction; Prostate Hyperplasia; Erectile Abnormalities; Prostatic Neoplasms
    Interventions
    Mirabegron; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2018-08-01
    Completion
    2020-01-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBPH; Erectile Dysfunction; Prostate Hyperplasia; Erectile Abnormalities +1 more
    InterventionMirabegron; placebo
    PhasePhase 2
    Registry statusUnknown

  • Prostatic Artery Embolization Versus Medical Treatment in Symptomatic Benign Prostatic Hyperplasia

    NCT02869971 · start 2016-08

    Registered record
    Registry ID
    NCT02869971
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    Embosphere® (Prostatic Arteries Embolization); Drug therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-08
    Completion
    2022-03-25
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    InterventionEmbosphere® (Prostatic Arteries Embolization); Drug therapy
    PhasePhase 3
    Registry statusCompleted

  • A Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Men With OAB Symptoms While Taking Tamsulosin Hydrochloride for Lower Urinary Tract Symptoms (LUTS) Due to Benign Prostatic Hyperplasia (BPH)

    NCT02757768 · start 2016-06-13

    Registered record
    Registry ID
    NCT02757768
    Conditions
    Benign Prostatic Hyperplasia; Overactive Bladder
    Interventions
    Mirabegron; Placebo; Tamsulosin Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-06-13
    Completion
    2018-09-11
    Enrolment
    715

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia; Overactive Bladder
    InterventionMirabegron; Placebo; Tamsulosin Hydrochloride
    PhasePhase 4
    Registry statusCompleted

  • Study to Compare the Safety and Pharmacokinetics of CKD-397

    NCT02645890 · start 2015-11

    Registered record
    Registry ID
    NCT02645890
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    CKD-397; TD+TM
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-11
    Completion
    2015-12
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    InterventionCKD-397; TD+TM
    PhasePhase 1
    Registry statusCompleted

  • The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil

    NCT03144596 · start 2015-10-29

    Registered record
    Registry ID
    NCT03144596
    Conditions
    Benign Prostatic Hyperplasia; Pupil Anomaly; Choroid Disease
    Interventions
    Alfuzosin Hydrochloride 10 MG; Tamsulosin Hydrochloride 0.4 MG
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-10-29
    Completion
    2016-11-19
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia; Pupil Anomaly; Choroid Disease
    InterventionAlfuzosin Hydrochloride 10 MG; Tamsulosin Hydrochloride 0.4 MG
    PhasePhase 4
    Registry statusCompleted

  • Determine the Bioequivalence of Two Formulations of Tamsulosin HCl Capsules in Fasted Male.

    NCT02417831 · start 2015-04-30

    Registered record
    Registry ID
    NCT02417831
    Conditions
    Prostatic Hyperplasia
    Interventions
    tamsulosin capsules; tamsulosin HCl
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-04-30
    Completion
    2015-05-31
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstatic Hyperplasia
    Interventiontamsulosin capsules; tamsulosin HCl
    PhasePhase 1
    Registry statusCompleted

  • Determine the Bioequivalence of Two Formulations of Tamsulosin HCl Capsules in Fed Male.

    NCT02417844 · start 2015-04

    Registered record
    Registry ID
    NCT02417844
    Conditions
    Prostatic Hyperplasia
    Interventions
    tamsulosin (Astellas); Tamsulosin HCL
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-04
    Completion
    2015-05
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstatic Hyperplasia
    Interventiontamsulosin (Astellas); Tamsulosin HCL
    PhasePhase 1
    Registry statusCompleted

  • Evaluating a Pharmacokinetic Drug Interaction Between Tadalafil and Tamsulosin

    NCT02239484 · start 2014-03

    Registered record
    Registry ID
    NCT02239484
    Conditions
    Erectile Dysfunction; Benign Prostatic Hyperplasia
    Interventions
    Tadalafil; Tamsulosin; Tadalafil + Tamsulosin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-03
    Completion
    2014-09
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErectile Dysfunction; Benign Prostatic Hyperplasia
    InterventionTadalafil; Tamsulosin; Tadalafil + Tamsulosin
    PhasePhase 1
    Registry statusCompleted